Spatial and seasonal dynamics of zooplankton functional groups and their relationship with environmental factors in urban rivers in Haikou City, China
In: Limnologica: ecology and management of inland waters, Volume 108, p. 126200
ISSN: 1873-5851
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In: Limnologica: ecology and management of inland waters, Volume 108, p. 126200
ISSN: 1873-5851
In: Environmental science and pollution research: ESPR, Volume 30, Issue 60, p. 125832-125845
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Volume 29, Issue 56, p. 85036-85049
ISSN: 1614-7499
In: JEMA-D-24-00274
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In: Environmental science and pollution research: ESPR, Volume 31, Issue 23, p. 33780-33793
ISSN: 1614-7499
In: Materials and design, Volume 220, p. 110839
ISSN: 1873-4197
In: info:eu-repo/semantics/altIdentifier/doi/10.2147/IJN.S202876
Jiulong Zhao,1,* Yangbei Zhu,1,* Changqing Ye,2,* Ying Chen,2 Shige Wang,2 Duowu Zou,3 Zhaoshen Li11Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, People's Republic of China; 2College of Science, University of Shanghai for Science and Technology, Shanghai 200093, People's Republic of China; 3Department of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, People's Republic of China *These authors contributed equally to this workBackground: Photothermal and chemotherapy treatment has been frequently studied for cancer therapy; however, chemotherapy is equally toxic to both normal and cancer cells. The clinical application value of most kinds of photothermal transforming agents remains limited, due to their poor degradation and minimal accumulation in tumors.Materials and methods: We reported the synthesis of photothermal transforming agents (MoS2) and chemotherapeutic (doxorubicin, DOX) co-loaded electrospun nanofibers using blend electrospinning for the treatment of postoperative tumor recurrence.Results: Under the irradiation of an 808 nm laser, the as-prepared chitosan/polyvinyl alcohol/MoS2/DOX nanofibers showed an admirable photothermal conversion capability with a photothermal conversion efficiency of 23.2%. These composite nanofibers are in vitro and in vivo biocompatible. In addition, they could control the sustained release of DOX and the generated heat can sensitize the chemotherapeutic efficacy of DOX via enhancing its release rate. Their chemo-/photothermal combined therapy efficiency was systematically studied in vitro and in vivo. Instead of circulating with the body fluid, MoS2 was trapped by the nanofibrous matrix in the tumor and so its tumor-killing ability was not compromised, thus rendering this composite nanofiber a promising alternative for future clinical translation within biomedical application fields.Conclusion: Chitosan/polyvinyl alcohol/MoS2/DOX nanofibers showed an excellent photothermal conversion capability with a photothermal conversion efficiency of 23.2% and can completely inhibit the postoperative tumor reoccurrence.Keywords: electrospinning, chitosan, chemotherapy, photothermal tumor therapy, tumor
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