HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry
Funding Information: The authors thank all participants, clinicians and researchers for making this study possible. This CRESTAR project has received funding from the European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreement #279227. M.P. wishes to thank the MRC Centre for Drug Safety Science (grant code MR/L006758/1) for support. A.F.P. acknowledges support by a "Springboard" award (ref: SBF005 \1083) from the Academy of Medical Sciences. J.T.R.W. and M.C.O. acknowledge support by a collaborative research grant from Takeda (Takeda played no part in the conception, design, implementation or interpretation of this study). Genome-wide data of CIAC used for identifying overlapping individuals were obtained from NIMH Repository & Genomics Resource, a centralized national biorepository for genetic studies of psychiatric disorders (www.nimhgenetics. org). The collection of data and biomaterials for this study was supported by funding provided by R01 MH080403 (PIs: P.F.S., Edwin J.C.G. van den Oord) from the US National Institute of Mental Health via the American Recovery and Reinvestment Act of 2009. Dr. Denis Fourches and Dr. Alexander Tropsha acknowledge the support from National Science Foundation grant ABI 10-567. The study was led by P.F.S., L. Fredrik Jarskog, Jeffrey A. Lieberman, J.L.K. and Mark J. Daly. Dr. Thomas Lehner (NIMH) and Dr. David Goldstein (Duke University) were also involved in assisting with this project. The authors acknowledge the assistance of Dr. Michael Karukin (Teva Pharmaceuticals) and Dr. Rafael Muniz and Dr. Vinod Kumar (Novartis) for help in accessing US national clozapine registries. Dr. Stanton Gerson (Department of Hematology, Case Western Reserve), Dr. Armond Goldman (Department of Immunology, University of Texas Galveston) and Dr. Nancy Berliner (Department of Hematology, Harvard University) provided input on mechanisms of agranulocytosis. Publisher Copyright: © 2021, The Author(s). ; The atypical antipsychotic ...