Mechanism of aging and mortality: the search for new paradigms
In: Monographs on population aging 7
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In: Monographs on population aging 7
In: The annals of the American Academy of Political and Social Science, Volume 503, Issue 1, p. 72-88
ISSN: 1552-3349
This article examines the evidence for two propositions: that health and ability to function can often be sustained into advanced old age through interventions that (1) control risk factors among people already old and (2) improve lifelong health behaviors and life-styles starting with people currently still young. Beginning with a general model of age-related changes in health, function, and survival, the article shows how the interrelationship between the three varies between two extreme types of diseases: the fast, lethal type, where death occurs early and rapidly, with few years spent in unhealthy or disabled conditions; and the slow, degenerative type, where prolonged survival allows for added years in unhealthy or disabled conditions. Since this latter type is predominant among older people in the United States today, interventions to prevent morbidity and functional loss are of critical importance. The need for an improved research base to guide such interventions is strongly urged.
In: The annals of the American Academy of Political and Social Science, Volume 503, p. 72-88
ISSN: 0002-7162
Based on a review of the literature, evidence for two propositions is examined: that health & ability to function can often be sustained into advanced old age through interventions that: (1) control risk factors among people already old; & (2) improve lifelong health behaviors & lifestyles among people currently still young. Beginning with a general model of age-related changes in health, function, & survival, it is shown how the interrelationship between the three varies between two extreme types of diseases: the fast, lethal type, where death occurs early & rapidly, with few years spent in unhealthy or disabled conditions; & the slow, degenerative type, where prolonged survival allows for added years in unhealthy or disabled conditions. Since this latter type is predominant among older people in the US today, interventions to prevent morbidity & functional loss are of critical importance & require an improved research base to guide them. 2 Tables, 3 Figures. HA
In: Journal of economic and social measurement, Volume 22, Issue 2, p. 141-160
ISSN: 1875-8932
In: Population and development review, Volume 16, Issue 1, p. 172
ISSN: 1728-4457
In: Socio-economic planning sciences: the international journal of public sector decision-making, Volume 19, Issue 4, p. 227-247
ISSN: 0038-0121
In: Risk analysis: an international journal, Volume 2, Issue 3, p. 183-193
ISSN: 1539-6924
Nonlinear hazard models are used to examine temporal trends in the age‐specific mortality risks of chronic obstructive lung diseases for the U.S. population. These hazard functions are fit to age‐specific mortality rates for 1968 and 1977 for four race/sex groups. Changes in the parameters of these models are used to assess two types of differences in the age pattern of the rates between 1968 and 1977. The first measure of trend in the age‐specific mortality rates is the temporal change in the proportionality constant in the function used to model their age variation. By allowing only this proportionality parameter to vary between 1968 and 1977, it is possible to determine an age‐constant percentage increase or decrease. The second measure reflects the absolute displacement in terms of years of life of the fitted mortality curves for the two time points. This second index can be interpreted as the acceleration or deceleration of mortality risks over the life span, i.e., the number of years that is needed for mortality rates to achieve the same level as in the comparison group. The analysis showed that the age changes in chronic obstructive lung disease mortality rates differed by race/sex group and for both measures of change over the period. Adjustment of the fitted curves for the effects of individual variability in risk was significant for three of four groups.
In: Mathematical population studies: an international journal of mathematical demography, Volume 15, Issue 3, p. 137-159
ISSN: 1547-724X
In: Mathematical population studies: an international journal of mathematical demography, Volume 4, Issue 2, p. 133-147
ISSN: 1547-724X
In: International journal of forecasting, Volume 8, Issue 3, p. 433-458
ISSN: 0169-2070
In: Population and development review, Volume 11, Issue 2, p. 358
ISSN: 1728-4457
In: Risk analysis: an international journal, Volume 27, Issue 2, p. 467-482
ISSN: 1539-6924
A microsimulation model, allowing one to forecast short‐ and long‐term population changes conditional on the prevalence of a risk factor in a population, is presented. In this model, population changes result from the aggregation of changes in individual event histories, which, in turn, result from mortality and infertility rates recalculated in accordance with their known relative risks in population groups exposed to a risk factor. Smoking, being the most widespread and influential preventable public health risk factor, is chosen to demonstrate the abilities of the model to forecast the population effects of different hypothetical smoking prevalences. The demographic and population health effects on 20‐, 50‐, and 100‐year projections with the current, hypothetically doubled, and hypothetically halved the current smoking prevalence are analyzed in detail. The model predicts an increase in life expectancy (0.99 year for males and 0.64 years for females), and an increase in population size (2.2–7.5% dependent on the age group) if smoking prevalence is reduced by half. Sensitivity analyses of all findings are performed. The generalization of the model to account for multiple risk factors (e.g., the simultaneous effects of alcohol consumption, obesity, and smoking) and effects on medical expenditures are discussed.
In: Population and development review, Volume 32, Issue 1, p. 81-105
ISSN: 1728-4457
In: Population and development review, Volume 17, Issue 4, p. 603
ISSN: 1728-4457