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In this article, we propose a mean linear regression model where the response variable is inverse gamma distributed using a new parameterization of this distribution that is indexed by mean and precision parameters. The main advantage of our new parametrization is the straightforward interpretation of the regression coefficients in terms of the expectation of the positive response variable, as usual in the context of generalized linear models. The variance function of the proposed model has a quadratic form. The inverse gamma distribution is a member of the exponential family of distributions and has some distributions commonly used for parametric models in survival analysis as special cases. We compare the proposed model to several alternatives and illustrate its advantages and usefulness. With a generalized linear model approach that takes advantage of exponential family properties, we discuss model estimation (by maximum likelihood), black further inferential quantities and diagnostic tools. A Monte Carlo experiment is conducted to evaluate the performances of these estimators in finite samples with a discussion of the obtained results. A real application using minerals data set collected by Department of Mines of the University of Atacama, Chile, is considered to demonstrate the practical potential of the proposed model.