Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response
Funding for this study was provided by: CancerResearch UK (C6199/A10417 and C399/A2291),the European Union Seventh Framework Programme(FP7/207-2013) grant 258236 collaborative projectSYSCOL, European Research Council project EVO-CAN, the Dutch Cancer Society, Research FundFlanders (F.W.O.) grant no. G.0827.13, the MedicalResearch Council, the Wellcome Trust and Departmentof Health as part of a Health Innovation ChallengeFund grant (R6-388), the National Institute for HealthResearch (NIHR) Oxford Biomedical Research Cen-tre, Ovarian Cancer Action and core funding to theWellcome Trust Centre for Human Genetics from theWellcome Trust (090532/Z/09/Z). The views expressedare those of the authors and not necessarily those ofthe NHS, the NIHR, the Department of Health or theWellcome Trust.DT is funded by an EPSRC doctoral training grantvia CoMPLEX. MG is funded by a Studentshipfrom the Wellcome Trust. TB is funded by theDutch Cancer Society Young Investigator Grant10418. ADB acknowledges funding from the Well-come Trust (102732/Z/13/Z), Cancer Research UK(C31641/A23923) and the Medical Research Coun-cil (MR/M016587/1). FA is a senior researcher forthe F.W.O. TG is a Cancer Research UK CareerDevelopment Fellow (A19771) and a Wellcome TrustInvestigator (202778/Z/16/Z). DNC is funded by aHealth Foundation/Academy of Medical SciencesClinician Scientist Fellowship.The cost of open access publication was provided bycore funding to the Wellcome Trust Centre for HumanGenetics from the Wellcome Trust (090532/Z/09/Z).