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The dissertation questions how and why the transition from coal to oil affected the economic relations between the Port of Rotterdam and its German hinterland between 1945 and 1975. From the 1880s onwards, Rotterdam had become the main seaport of the German industrial heartland in the Ruhr area. The transition from coal to oil in the 1950s and 1960s required a new infrastructure – pipelines – to supply the expanding West German market with crude oil. Despite its intimate transport relations to the German hinterland, Rotterdam faced competition from other ports. The West German federal government favoured a German port over Rotterdam, whereas multinational oil companies pursued an integrated Trans-European pipeline system starting in the French port of Marseille. However, the lack of European political and economic integration ultimately ended the Trans-European pipeline project. The Rotterdam port benefited from the outcome because a pipeline connection was established to the German hinterland as a result of the failure of the Trans-European pipeline plan. This gave Rotterdam a captive hinterland in West Germany, a position it still enjoys today. The thesis highlights how transnational economic relations are threatened by economic and technological change and are conditioned by the tensions between national politics and international business. The study uses a business historical approach and combines a transnational case study of Royal Dutch Shell with Dutch and German public archival material.

Data on primary ciliary dyskinesia (PCD) epidemiology is scarce and published studies are characterised by low numbers. In the framework of the European Union project BESTCILIA we aimed to combine all available datasets in a retrospective international PCD cohort (iPCD Cohort). We identified eligible datasets by performing a systematic review of published studies containing clinical information on PCD, and by contacting members of past and current European Respiratory Society Task Forces on PCD. We compared the contents of the datasets, clarified definitions and pooled them in a standardised format. As of April 2016 the iPCD Cohort includes data on 3013 patients from 18 countries. It includes data on diagnostic evaluations, symptoms, lung function, growth and treatments. Longitudinal data are currently available for 542 patients. The extent of clinical details per patient varies between centres. More than 50% of patients have a definite PCD diagnosis based on recent guidelines. Children aged 10–19 years are the largest age group, followed by younger children (⩽9 years) and young adults (20–29 years). This is the largest observational PCD dataset available to date. It will allow us to answer pertinent questions on clinical phenotype, disease severity, prognosis and effect of treatments, and to investigate genotype–phenotype correlations.