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Frontmatter -- Contents -- Acknowledgments -- Introduction: Feminist Politics and Postfeminist Culture -- 1. Postfeminism and Popular Culture: Bridget Jones and the New Gender Regime -- 2. Mass Magazine Cover Girls: Some Reflections on Postfeminist Girls and Postfeminism's Daughters -- 3. Living a Charmed Life: The Magic of Postfeminist Sisterhood -- 4. "I Hate My Job, I Hate Everybody Here": Adultery, Boredom, and the "Working Girl" in Twenty-First-Century American Cinema -- 5. Remapping the Resonances of Riot Grrrl: Feminisms, Postfeminisms, and "Processes" of Punk -- 6. Killing Bill: Rethinking Feminism and Film Violence -- 7. Queer Eye for the Straight Guise: Camp, Postfeminism, and the Fab Five's Makeovers of Masculinity -- 8. What's Your Flava? Race and Postfeminism in Media Culture -- 9. The Fashion Police: Governing the Self in What Not to Wear -- 10. Divas, Evil Black Bitches, and Bitter Black Women: African American Women in Postfeminist and Post-Civil-Rights Popular Culture -- 11. Subjects of Rejuvenation: Aging in Postfeminist Culture 277 Sadie Wearing -- Bibliography -- Contributors -- Index

A sarcopenia desencadeia inúmeras repercussões na saúde e qualidade de vida da pessoa idosa, enfatizando a necessidade do diagnóstico e tratamento precoce. Com isso, torna-se evidente a significância de conhecer os principais fatores desencadeantes dessa condição, bem como os pacientes suscetíveis a essa desordem, a fim de elaborar e implementar uma assistência qualificada, um plano terapêutico e nutricional para aproximar o índice de massa corporal a valores considerados adequados. Objetivou-se analisar a influência do índice de massa corporal como fator de risco para o desenvolvimento da sarcopenia no público idoso de acordo com a literatura científica. Trata-se de uma revisão integrativa de literatura realizada através das bases de dados da Biblioteca Virtual em Saúde. Após o levantamento dos dados obteve-se 1066 resultados, que com a aplicação dos critérios de inclusão restaram 13 artigos para compor a amostra. O resultado final desta revisão incluiu pesquisas realizadas em nove países distintos: Brasil, China, Tailândia, Turquia, África do Sul, Japão, Coreia do Sul, Nova Zelândia e Itália. Verificou-se que 69% dos estudos evidenciaram que os idosos com risco de sarcopenia apresentavam, dentre outros fatores de risco, o baixo índice de massa corporal, alimentação deficiente e quadros de desnutrição, além do fato de que aqueles com maior obesidade central apresentavam menos acometimento pela doença. Concluiu-se que o índice de massa corporal é um importante fator de risco de para a sarcopenia, não anulando o fato de que é imprescindível padronizar os critérios diagnósticos para a doença utilizando outros fatores além da massa muscular.

In this article, the authors, using the example of Nizhny Novgorod, examined the dynamics of changes in the relationship between society and government in the Russo-Japanese War. The attitude of the classes to the war and its results, as well as the impact that the conclusion of the Portsmouth Peace had on the development of the revolutionary movement in the province were analyzed. The authors noted that in the initial stages of the war, the population of the Nizhny Novgorod province responded with a surge of patriotic sentiments, expressed in the active collection of donations, the arrangement of hospitals, and the sending of military ambulance trains to the front. However, the patriotic outburst, which manifested itself clearly at the beginning of the war, was re-placed, first by openly expressed discontent, and subsequently by a revolutionary outburst in the province, which the authorities managed to suppress with great difficulty. Conclusion dwells upon the fact that the course of hostilities in the Russo-Japanese War of 1904–1905 was projected by the population on their own relations with the authorities and found a mirror image in the imperial hinterland.

This article reviews and summarizes current reproduction and replication practices in political science. We first provide definitions for reproducibility and replicability. We then review data availability policies for 28 leading political science journals and present the results from a survey of editors about their willingness to publish comments and replications. We discuss new initiatives that seek to promote and generate high-quality reproductions and replications. Finally, we make the case for standards and practices that may help increase data availability, reproducibility, and replicability in political science.

AbstractIntroductionAntiretroviral therapy (ART) monitoring using viral load (VL) testing is challenging in high‐burden, limited‐resources settings. Chemokine IP‐10 (interferon gamma‐induced protein 10) strongly correlates with human immunodeficiency virus (HIV) VL. Its determination could serve to predict virological failure (VF) and to triage patients requiring VL testing. We assessed the field performance of a semi‐quantitative IP‐10 lateral flow assay (LFA) for VF screening in South Africa, and the cost‐effectiveness of its implementation in Mozambique.MethodsA cross‐sectional study was conducted between June and December 2021 in three primary health clinics in the Western Cape. Finger prick capillary blood was collected from adults on ART for ≥1 year for direct application onto the IP‐10 LFA (index test) and compared with a plasma VL result ≤1 month prior (reference test). We estimated the area under the receiver operating characteristic curves (AUC), sensitivity and specificity, to evaluate IP‐10 LFA prediction of VF (VL>1000 copies/ml). A decision tree model was used to investigate the cost‐effectiveness of integrating IP‐10 LFA combined with VL testing into the current Mozambican ART monitoring strategy. Averted disability‐adjusted life years (DALYs) and HIV acquisitions, and incremental cost‐effectiveness ratios were estimated.ResultsAmong 209 participants (median age 38 years and 84% female), 18% had VF. Median IP‐10 LFA values were higher among individuals with VF compared to those without (24.0 vs. 14.6; p<0.001). The IP‐10 LFA predicted VF with an AUC = 0.76 (95% confidence interval (CI) 0.67–0.85), 91.9% sensitivity (95% CI 78.1–98.3) and 35.1% specificity (95% CI 28.0–42.7). Integrating the IP‐10 LFA in a setting with 20% VF prevalence and 61% VL testing coverage could save 13.0% of costs and avert 14.9% of DALYs and 55.7% new HIV acquisitions. Furthermore, its introduction was estimated to reduce the total number of routine VL tests required for ART monitoring by up to 68%.ConclusionsThe IP‐10 LFA is an effective VF triage test for routine ART monitoring. Combining a highly sensitive, low‐cost IP‐10 LFA‐based screening with targeted VL confirmatory testing could result in significant healthcare quality improvements and cost savings in settings with limited access to VL testing.

The article examines the genesis of the Christian anti-Trinitarian movement in the Polish-Lithuanian state and the subsequent formation of the Lesser Reformed Church. To achieve this goal, the authors identify three main factors that in their combination led to the unique situation of the emergence of religious freedom in the Polish-Lithuanian state in the second half of the XVI century, including: weak royal power, the struggle of Catholic and Orthodox religious denominations, and a tense foreign policy situation. According to the article, the creation of the Minor Reformed Church was a landmark event in the history of the country and Europe, as it consolidated the position of the adherents of Christian anti-trinitarian ideas. The article distinguishes and describes the char-acteristic features of the Polish radical Reformation, playing an important role in the formation of Christian ide-as based on the belief in One God and rejecting the concept of the Trinity in Europe as well as contributing to the development of social thought, culture and science of all the peoples of the Polish-Lithuanian state.

ObjectivesOur preliminary work revealed significant variations in the prescribing of end-of-life symptom management medications in nursing homes prior to the onset of the COVID-19 pandemic. In this study, we sought to explore whether the prescribing of end-of-life medications in nursing homes changed with the onset of the pandemic.
ApproachThis was a retrospective cohort study of nursing home residents age 65+ who died in Ontario, Canada, divided into two time periods based on death date: pre-COVID-19 (January 1st, 2017 – March 17th, 2020) and during COVID-19 (March 18th, 2020 – March 31st, 2021). Using routinely collected health administrative data and our evidence-based end-of-life medications list, we linked resident data to prescription claims to identify whether residents were prescribed these medications in the last 14 days of life. We grouped homes into quintiles according to the proportion of decedents who received ≥1 prescription and examined changes in prescribing before and during COVID-19.
ResultsNursing homes in the lowest prescribing quintile prescribed, on average, 11.5% fewer end-of-life symptom management medications during COVID-19 compared to pre-pandemic. Conversely, homes in the highest quintile prescribed an average of 13.7% more medications during COVID-19. Nursing homes in the lowest quintile had more COVID-19-positive residents (33% of residents) compared to homes in the highest quintile (9% of residents). Additionally, nursing homes in the lowest prescribing quintile spent more time with active COVID-19 outbreaks compared to homes in the highest quintile (mean 72.7 days versus 24.1 days, respectively, standardized difference 0.819).
ConclusionThe COVID-19 pandemic has disproportionately impacted nursing homes across Canada. Our findings suggest that nursing homes with low rates of prescribing of end-of-life medications prior to the pandemic had even lower prescribing rates during the pandemic. These homes were also harder hit by COVID-19 infections and outbreaks.

ObjectivesPrescribing of symptom management medications may reflect the quality of end-of-life care provided to nursing home residents who are nearing death. The objective of this study was to examine variations in the prescribing of end-of-life symptom management medications in nursing home residents in the last 14 days of life.
ApproachThis was a retrospective cohort study of nursing home residents age 65+ who died in Ontario, Canada between January 2017 and February 2020. Through expert consultations, we compiled a list of medications used to manage common end-of-life symptoms. Using routinely collected health administrative data held at ICES, we linked resident data to prescription claims to identify whether residents were prescribed these medications in the last 14 days of life. We grouped nursing homes into quintiles according to the proportion of decedents in a home who received ≥1 prescription and examined variations in resident and facility characteristics across quintiles.
ResultsThere were 55,029 deaths across 626 nursing homes. Overall, 64.8% of residents received at least one end-of-life symptom management medication. The proportion of dying residents who received ≥1 end-of-life medication ranged from 37.6% in quintile 1, 59.8% in quintile 2, 69.1% in quintile 3, 74.8% in quintile 4, and 82.9% in quintile 5. Opioids were the most commonly prescribed medications, with an average of 62.2% of residents receiving a prescription (35.9% to 81.2% across the quintiles). Nursing home residents that resided in homes in the lowest prescribing quintile were older and more likely to be Allophones (first language not English or French). Low prescribing homes were also larger, with a higher number of beds, and were more likely to be in rural areas.
ConclusionThe observed variations in the prescribing of medications to manage end-of-life symptoms in nursing home residents raises concerns that some residents may have received inadequate end-of-life symptom management. Prescription data may provide an opportunity to rapidly evaluate the quality of end-of-life care in nursing homes at a population level.

Abstract
Immunoglobulin E (IgE) antibody is a critical effector molecule for adaptive allergen-induced immune responses, which affect up to 40% of the population worldwide. Allergens are usually innocuous molecules but induce IgE antibody production in allergic subjects. Allergen cross-linking of IgE bound to its high affinity receptor (FcεRI) on mast cells and basophils triggers release of histamine and other mediators that cause allergic symptoms. Little is known about the direct allergen–IgE antibody interaction due to the polyclonal nature of serum IgE and the low frequency of IgE-producing B cells in blood. Here, we report the X-ray crystal structure of a house dust mite allergen, Der p 2, in complex with Fab of a human IgE monoclonal antibody (mAb) isolated by hybridoma technology using human B cells from an allergic subject. This IgE mAb, 2F10, has the correct pairing of heavy and light chains as it occurs in vivo. Key amino acids forming the IgE epitope on Der p 2 were identified. Mutation of these residues ablated their functional ability to cross-link IgE in a mouse model of passive systemic anaphylaxis. These analyses revealed an important conformational epitope associated with the IgE antibody repertoire to a major mite allergen.

Layer II of Kostenki 17 has yielded one of the earliest Upper Palaeolithic assemblages in Eastern Europe. In addition to lithic and bone implements, the collection includes numerous ornaments with perforated holes made from fox teeth, petrified remains and soft stones. This collection of ornaments is unique in both the variety of raw materials and the peculiarity of manufacturing technologies. The paper presents the results of a use-wear study of these ornaments, designed to answer the questions about how the raw materials were selected and processed, how the finished adornments were used and what could have been the ways of their getting into the cultural layer. All petrified remains as well as pebbles and faunal materials come from local sources. The processing of belemnite rostras involved a rather complex sequence of different techniques from drilling and engraving to termo-chemical surface treatment. Cutting and abrasion were used to produce some pendants made of soft stone. It is shown that the set of techniques used to make stripes of fox teeth was more diverse than previously thought.