Suchergebnisse

Abstract
Background
Exposure to airborne fine particulate matter (PM2.5) has been declared to be harmful to human kidney. However, whether activation of the autophagic pathway plays key roles in the nephrotoxicity caused by PM2.5 exposure is still poorly understood. The aim of this study was to explore the mechanism of kidney damage after PM2.5 exposure in vivo and in vitro.

Results
In the present study, statistically significant alterations in water intake, urine flow rate and mean blood pressure were observed between the concentrated PM2.5 (PM2.5) group and the filtered air (FA) group. Exposed animals showed severe edema of renal tubular epithelial cells, capillary congestion, reduction of the glomerular urinary space and early pro-fibrotic state. Moreover, significant increases in the levels of early kidney damage markers were observed in the exposed rats and these animals exhibited more apoptosis rate in kidney cells. In addition, PM2.5 exposure activated the autophagic pathway, as evidenced by LC3-I to LC3-II conversion, activation of P62 and beclin-1. All of these effects are in concurrence with the presence of more autophagosomes both in vivo and in vitro after PM2.5 exposure.

Conclusions
Taken together, our findings indicated that PM2.5 induced renal function impairment via the activation of the autophagic pathway in renal tubular epithelial cells.

It is difficult to support the needs of MPAcc teaching due to the insufficient number of case libraries for business ethics and accounting ethics courses. Therefore, this paper discusses the necessity of the case library from the current situation of case library construction, and analyzes the research and construction of the case library of business ethics and accounting ethics course, and proposes, some corresponding solutions to improve students' classroom learning effect, so as to better cultivate high quality and high level applied talents, which has a certain reference role for universities to improve the subject case library.