Suchergebnisse

[cat] Aquesta tesi estudia la Falange a Mallorca des de que es va implantar a l'illa, el 1934, fins que va deixar de tenir el protagonisme que havia assolit durant la Guerra Civil, en funció de l'evolució bèl·lica i política europea. L'objecte d'estudi no és pròpiament el partit com a institució sinó com a conjunt d'afiliats. Per aquest motiu s'ha recollit tota la documentació que aporta informació sobre les dades personals dels falangistes (incloses les afiliades a la Secció Femenina) que es conserva als arxius públics de Mallorca, amb especial atenció als dels 52 municipis de l'illa existents durant els anys tractats. S'ha localitzat més documentació de l'esperada: fitxes d'afiliats, expedients personals, sol·licituds d'afiliació, llibres registre d'afiliats, etc. A través de les dades que aporten s'ha pogut analitzar el conjunt d'afiliats resultant, que té el valor d'una mostra significativa, des de molts punts de vista. En tots els casos les variables bàsiques són les professions, edats i quotes mensuals assignades (però també les dates d'afiliació, les línies i antecedents polítics). Aquests diversos punts de vista constitueixen la raó de ser de cada capítol que, després de repassar els precedents polítics de caire corporativista durant la Dictadura de Primo de Rivera i la Segona República, són: Evolució de les incorporacions i nivell socioeconòmic dels afiliats, Antecedents polítics, Membres de la F.E.T. y de las J.O.N.S. procedents de la Comunió Tradicionalista, Falangistes que exerciren càrrecs dins del partit i altres responsabilitats, Persones que presentaven als falangistes al partit, La Falange com a cos armat, Falangistes procedents de les milícies ciutadanes i integrats a les milícies nacionals, Falangistes a l'exèrcit, Falangistes valencians i catalans refugiats a l'illa, Ocupacions de les falangistes dins del partit, El cos d'infermeres de la Falange i Evolució de les baixes. ; [eng] This thesis studies the Falange in Mallorca from the time it was first established in the Island in 1934 until it lost the leading role it had acquired during the Civil War, in terms of European political and military evolution. The objective of the study is not exactly that of the party as an institution but as a group of affiliates. For this reason, all the documentation was collected that contributed information to personal data on the Falangists (also on those who were members of the Female Section) which is preserved in the public archives throughout Mallorca, paying special attention to the 52 Island Municipalities during the years in question. More documentation than expected was located: files on members, personal dossiers, requests for memberships, registration books of members, etc. Through the data they supplied, it was possible to analyse the resulting group of members which has the value of a significant sample from many points of view. In every case, the basic variables are professions, ages and specified membership fees (in addition to dates of affiliation, political affiliations and antecedents). These diverse points of view constitute tre raison d'être of each chapter which, after reviewing the political precedents of a collectivist type during the dictatorship of Primo de Rivera and the Second Republic, are: Evolution of membership and socio-economic levels of the members, Political antecedents, Members of the Falange Española Tradicionalista y de las J.O.N.S. proceeding from the Comunión Tradicionalista, Falangists who exercised office within the party and other responsabilities, People who introduced Falangists to the party, the Falange as an armed body, Falangists from citizens militia and integrated in national militias, Falangists in the army, Falangists from Valencia and Catalonia who had taken refuge in the Island, Occupations of Falangists (members of the Female Section) whitin the party, the Falange Nursing Corps and the evolution of the fall in membership.

Purpose: To develop quercetin-loaded phospholipid vesicles, namely liposomes and PEVs (Penetration Enhancer-containing Vesicles), and to investigate their efficacy on TPA-induced skin inflammation. Methods: Vesicles were made from a mixture of phospholipids, quercetin and polyethylene glycol 400 (PEG), specifically added to increase drug solubility and penetration through the skin. Vesicle morphology and self-assembly were probed by Cryo-Transmission Electron Microscopy and Small/Wide Angle X-ray Scattering, as well as the main physico-chemical features by Light Scattering. The anti-inflammatory efficacy of quercetin nanovesicles was assessed in vivo on TPA-treated mice dorsal skin by the determination of two biomarkers: oedema formation and myeloperoxidase activity. The uptake of vesicles by 3T3 fibroblasts was also evaluated. Results: Small spherical vesicles were produced. Their size and lamellarity was strongly influenced by the PEG content (0%, 5%, 10% v/v). The administration of vesicular quercetin on TPA-inflamed skin resulted in an amelioration of the tissue damage, with a noticeable attenuation of oedema and leukocyte infiltration, especially using 5% PEG-PEVs, as also confirmed by confocal microscopy. In vitro studies disclosed a massive uptake and diffusion of PEVs in dermal fibroblasts. Conclusions: The proposed approach based on quercetin vesicular formulations may be of value in the treatment of inflammatory skin disorders. ; This study was supported by a grant from the University of Valencia (Relacions Internacionals I Cooperació), a grant from MIUR, Italy (PRIN 2010-2011, Prot. 2010H834LS_004), a grant from the Ministerio de Ciencia e Innovación, Spain (BIO2011-25039), which included FEDER funds, and by a grant from the Generalitat de Catalunya, Spain (2009SGR-760). Dr. C. Caddeo gratefully acknowledges Sardinia Regional Government for the financial support (P.O.R. Sardegna F.S.E. Operational Programme of the Autonomous Region of Sardinia, European Social Fund 2007-2013 - Axis IV Human Resources, Objective l.3, Line of Activity l.3.1 "Avviso di chiamata per il finanziamento di Assegni di Ricerca". ; Peer reviewed

We designed niosomes based on three lipids that differed only in the polar-head group to analyze their influence on the transfection efficiency. These lipids were characterized by small-angle X-ray scattering before being incorporated into the niosomes which were characterized in terms of pKa, size, zeta potential, morphology and physical stability. Nioplexes were obtained upon the addition of a plasmid. Different ratios (w/w) were selected to analyze the influence of this parameter on size, charge and the ability to condense, release and protect the DNA. In vitro transfection experiments were performed in HEK-293, ARPE-19 and MSC-D1 cells. Our results show that the chemical composition of the cationic head-group clearly affects the physicochemical parameters of the niosomes and especially the transfection efficiency. Only niosomes based on cationic lipids with a dimethyl amino head group (lipid 3) showed a transfection capacity when compared with their counterparts amino (lipid 1) and tripeptide head-groups (lipid 2). Regarding cell viability, we clearly observed that nioplexes based on the cationic lipid 3 had a more deleterious effect than their counterparts, especially in ARPE-19 cells at 20/1 and 30/1 ratios. Similar studies could be extended to other series of cationic lipids in order to progress in the research on safe and efficient non-viral vectors for gene delivery purposes. ; This project was partially supported by the University of the Basque Country UPV/EHU (UFI 11/32), the National Council of Science and Technology (CONAYT), Mexico, Reg. # 217101, the Spanish Ministry of Education (Grant CTQ2010-20541, CTQ2010-14897), the Basque Government (Department of Education, University and Research, predoctoral BFI-2011-2226 grant), the Generalitat de Catalunya (2009SGR208, 2009SGR1331) and the Instituto de Salud Carlos III. Technical and human support provided by SGIker (UPV/EHU) is gratefully acknowledged. Authors also wish to thank the intellectual and technical assistance from the platform for Drug Formulation (NANBIOSIS) CIBER-BBN. ; Peer reviewed

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/jacs.9b12389 ; Covalent organic frameworks (COFs) are commonly synthesized under harsh conditions yielding unprocessable powders. Control in their crystallization process and growth has been limited to studies conducted in hazardous organic solvents. Herein, we report a one-pot synthetic method that yields stable aqueous colloidal solutions of sub-20 nm crystalline imine-based COF particles at room temperature and ambient pressure. Additionally, through the combination of experimental and computational studies, we investigated the mechanisms and forces underlying the formation of such imine-based COF colloids in water. Further, we show that our method can be used to process the colloidal solution into 2D and 3D COF shapes as well as to generate a COF ink that can be directly printed onto surfaces. These findings should open new vistas in COF chemistry, enabling new application areas ; This work was supported by the European Union (ERC-2015-STG microCrysFact 677020), the Swiss National Science Foundation (Project No. 200021_181988), ETH Zürich and Ministry of Science, Innovation and Universities MICINN (MAT2016-77608-C3-1P). R.P. acknowledges the Spanish MINECO (Grant No. CTQ2017—88948-P). A.E.P.P. acknowledges a TALENTO grant (2017-T1/IND5148) from Comunidad de Madrid. I.S. acknowledges the Ministry of Human Capacities of Hungary (20391-/2018/FEKUSTRAT). G.M.P. acknowledges the funding received by the Swiss National Science Foundation (SNSF grant number 200021_175735) and by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No. 818776 - DYNAPOL). D.M. acknowledges financial support from the European Union (ERC-Co 615954). ICN2 is supported by the Severo Ochoa program from the Spanish MINECO (Grant No. SEV-2017-0706). S.P. acknowledges funding from a Consolidator Grant from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (Grant Agreement No. 771565). We acknowledge DESY (Hamburg, Germany), a member of the Helmholtz Association HGF, for the provision of experimental facilities. Synchrotron X-ray diffraction experiments with COF-TAPB-BTCA were carried out at the beamline P02.1 PETRA III under the proposal I-20170717 EC. We acknowledge Jaume Caelles for SAXS/WAXS measurements performed at IQAC–CSIC.