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Institutional intermediaries are often seen by governments as avenues for increasing firm level innovativeness. This is because they can provide both information and legitimacy, which enable access to government support. Yet, close engagement with intermediaries may also encourage political intervention, especially in the context of emerging markets. Using a unique dataset which consists of the Chinese Micro- and Small- Enterprise Survey (CMES) and the National Economic Research Institute (NERI), we explore the roles of government support and political intervention in the relationship between institutional linkages and firm innovativeness. We find that government support, in the form of tax benefits, and political intervention mediate the relationship between institutional linkages and firm innovativeness. We also find that this relationship is contingent upon the degree of institutional development within which firms operate. Our findings therefore contribute to the burgeoning literature that examines the effects of institutional intermediaries on innovation by exploring both their bright and dark sides. We discuss the implications of these findings for institutional intermediary research, institutional theory and innovation literature and offer advice to policymakers and managers looking at improving innovativeness.

Mandatory civil building energy efficiency codes strictly govern the energy consumption of new buildings in China. As the promotion of building energy efficiency in China has increased in recent years, compliance with mandatory civil building energy efficiency codes has also improved, increasing from less than 10% in 2000 to nearly 100% in 2012, a remarkable achievement. However, because the promotion of energy efficiency strategies in China has followed a unique pattern, some researchers doubt these statistics. In response to these doubts, this paper summarises and analyses the framework of measures implemented by the Chinese government to enforce mandatory building energy efficiency codes. First, the development and implementation of China's mandatory civil building energy efficiency code system is summarised. Second, the building supervision and inspection systems used to assess energy efficiency are introduced and analysed in detail in order to provide a framework for the development of energy policies in other countries. Third, the assessment and reporting processes used to determine compliance rates are reviewed. Finally, the improvement of compliance rates and its impact on building energy savings in China are discussed. Along with the increase in compliance rates in the construction stage from 71% in 2007 to 100% in 2012, the energy savings of new buildings per increased floor area per year increased from 20.4 kWh/m2 to 28.4 kWh/m2. The supervision and inspection systems reported in this paper are the keys to enforcing building energy efficiency codes.

BACKGROUND: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. METHODS: Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP). RESULTS: We did not find any variant associated with breast cancer-specific mortality at P < 5 × 10-8. For ER-positive disease, the most significantly associated variant was chr7:rs4717568 (BFDP = 7%, P = 1.28 × 10-7, hazard ratio [HR] = 0.88, 95% confidence interval [CI] = 0.84-0.92); the closest gene is AUTS2. For ER-negative disease, the most significant variant was chr7:rs67918676 (BFDP = 11%, P = 1.38 × 10-7, HR = 1.27, 95% CI = 1.16-1.39); located within a long intergenic non-coding RNA gene (AC004009.3), close to the HOXA gene cluster. CONCLUSIONS: We uncovered germline variants on chromosome 7 at BFDP < 15% close to genes for which there is biological evidence related to breast cancer outcome. However, the paucity of variants associated with mortality at genome-wide significance underpins the challenge in providing genetic-based individualised prognostic information for breast cancer patients. ; BCAC is funded by Cancer Research UK [C1287/A16563 and C1287/A10118], the European Union's Horizon 2020 Research and Innovation Programme (Grant numbers 634935 and 633784 for BRIDGES and B-CAST, respectively), and by the European Community's Seventh Framework Programme under grant agreement number 223175 (Grant number HEALTH-F2-2009-223175) (COGS).