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AbstractThe risk for a global transmission of flu‐type viruses is strengthened by the physical contact between humans and accelerated through individual mobility patterns. The Air Transportation System plays a critical role in such transmissions because it is responsible for fast and long‐range human travel, while its building components—the airports—are crowded, confined areas with usually poor hygiene. Centers for Disease Control and Prevention (CDC) and World Health Organization (WHO) consider hand hygiene as the most efficient and cost‐effective way to limit disease propagation. Results from clinical studies reveal the effect of hand washing on individual transmissibility of infectious diseases. However, its potential as a mitigation strategy against the global risk for a pandemic has not been fully explored. Here, we use epidemiological modeling and data‐driven simulations to elucidate the role of individual engagement with hand hygiene inside airports in conjunction with human travel on the global spread of epidemics. We find that, by increasing travelers engagement with hand hygiene at all airports, a potential pandemic can be inhibited by 24% to 69%. In addition, we identify 10 airports at the core of a cost‐optimal deployment of the hand‐washing mitigation strategy. Increasing hand‐washing rate at only those 10 influential locations, the risk of a pandemic could potentially drop by up to 37%. Our results provide evidence for the effectiveness of hand hygiene in airports on the global spread of infections that could shape the way public‐health policy is implemented with respect to the overall objective of mitigating potential population health crises.

Urban mobility analysis using Twitter as a proxy has gained significant attention in various application fields; however, long-term validation studies are scarce. This paper addresses this gap by assessing the reliability of Twitter data for modeling inner-urban mobility dynamics over a 27-month period in the metropolitan area of Rio de Janeiro, Brazil. The evaluation involves the validation of Twitter-derived mobility estimates at both temporal and spatial scales, employing over 1.6 × 1011 mobile phone records of around three million users during the non-stationary mobility period from April 2020 to June 2022, which coincided with the COVID-19 pandemic. The results highlight the need for caution when using Twitter for short-term modeling of urban mobility flows. Short-term inference can be influenced by Twitter policy changes and the availability of publicly accessible tweets. On the other hand, this long-term study demonstrates that employing multiple mobility metrics simultaneously, analyzing dynamic and static mobility changes concurrently, and employing robust preprocessing techniques such as rolling window downsampling can enhance the inference capabilities of Twitter data. These novel insights gained from a long-term perspective are vital, as Twitter - rebranded to X in 2023 - is extensively used by researchers worldwide to infer human movement patterns. Since conclusions drawn from studies using Twitter could be used to inform public policy, emergency response, and urban planning, evaluating the reliability of this data is of utmost importance.