Suchergebnisse

In this study, we investigate the role of public governance in mediating the impact of a country's culture on money laundering. We assess whether interference in the form of public governance can reduce or offset cultural effects with respect to the risks associated with money laundering across 92 countries over a 6‐year period (2012–2017).Design/methodology/approachThis research uses structural modeling to examine the direct path between culture and money laundering, and the indirect path between culture and money laundering that passes through public governance as a mediator. We use Hofstede's cultural variables as a proxy for measuring culture, and Worldwide Governance Indicators (WGIs) to measure public governance in different countries. The Basel anti‐money laundering index is also used as a proxy for measuring money laundering risk.FindingsOur results show that public governance fully mediates the relationship between culture and money laundering. The direct path shows a significant relationship between culture and money laundering, but this relationship becomes insignificant when public governance is introduced as a mediator.Originality/valueThis study indicates that governments can reduce money‐laundering risk by paying more attention to the quality of public governance and its potential as a tool in reducing money laundering.

Background A sexual dimorphism exists in the incidence and prevalence of coronary artery disease—men are more commonly affected than are age-matched women. We explored the role of the Y chromosome in coronary artery disease in the context of this sexual inequity. Methods We genotyped 11 markers of the male-specific region of the Y chromosome in 3233 biologically unrelated British men from three cohorts: the British Heart Foundation Family Heart Study (BHF-FHS), West of Scotland Coronary Prevention Study (WOSCOPS), and Cardiogenics Study. On the basis of this information, each Y chromosome was tracked back into one of 13 ancient lineages defined as haplogroups. We then examined associations between common Y chromosome haplogroups and the risk of coronary artery disease in cross-sectional BHF-FHS and prospective WOSCOPS. Finally, we undertook functional analysis of Y chromosome effects on monocyte and macrophage transcriptome in British men from the Cardiogenics Study. Findings Of nine haplogroups identified, two (R1b1b2 and I) accounted for roughly 90% of the Y chromosome variants among British men. Carriers of haplogroup I had about a 50% higher age-adjusted risk of coronary artery disease than did men with other Y chromosome lineages in BHF-FHS (odds ratio 1·75, 95% CI 1·20–2·54, p=0·004), WOSCOPS (1·45, 1·08–1·95, p=0·012), and joint analysis of both populations (1·56, 1·24–1·97, p=0·0002). The association between haplogroup I and increased risk of coronary artery disease was independent of traditional cardiovascular and socioeconomic risk factors. Analysis of macrophage transcriptome in the Cardiogenics Study revealed that 19 molecular pathways showing strong differential expression between men with haplogroup I and other lineages of the Y chromosome were interconnected by common genes related to inflammation and immunity, and that some of them have a strong relevance to atherosclerosis. Interpretation The human Y chromosome is associated with risk of coronary artery disease in men of European ancestry, possibly through interactions of immunity and inflammation. Funding British Heart Foundation; UK National Institute for Health Research; LEW Carty Charitable Fund; National Health and Medical Research Council of Australia; European Union 6th Framework Programme; Wellcome Trust.