Suchergebnisse

Increasing product lifespans is one of the most effective environmental strategies and therefore repair is a part of the circular economy approach that aims to keep products and materials longer in use. This article explores drivers and barriers for repair from consumers' and commercial repair actors' viewpoints, in order to understand how the repair rates of household appliances, mobile phones and clothing could be increased. The study is based on a consumer survey of 1196 respondents in Norway, and 15 qualitative interviews with actors in the commercial repair industry working with repairs of household consumer goods. A surprisingly high share of repairs was conducted by consumers themselves. The main barrier is the consistently low price of new products, and often of poor quality, which contributes to low profitability in repair work for businesses and low motivation from consumers. Furthermore, access to competent personnel is a major challenge for the repair industry, a need which is expected to increase in the coming years. Both the industry and consumers agree that better quality of products is a starting point for increased product lifespans, and this will also increase the motivation and the number of profitable repairs. These results have political implications on how to promote longer product lifespans through repair such as increased utilization and knowledge of consumers' complaint and warranty rights. ; The research project was supported by the Norwegian Ministry of Children and Families. Article writing was supported by the Consumption Research Norway (SIFO), Oslo Metropolitan University and Research Council of Norway [grant number 303080]. ; publishedVersion

The existence of 'cancer stem cells' (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types.

Cover title. ; "June 1990." ; Shipping list no.: 90-470-P. ; Mode of access: Internet.

AbstractThe design of a system with many locations, each with many items which may fail while in use, is considered. When items fail, they require repair; the particular type of repair being governed by a probability distribution. As repairs may be lengthy, spares are kept on hand to replace failed items. System ineffectiveness is measured by expected weighted shortages over all items and locations, in steady state. This can be reduced by either having more spares or shorter expected repair times. Design consists of a provisioning of the number of spares for each item, by location; and specifying the expected repair times for each type of repair, by item and location. The optimal design minimizes expected shortages within a budget constraint, which covers both (i) procurement of spares and (ii) procurement of equipment and manning levels for the repair facilities. All costs are assumed to be separable so that a Lagrangian approach is fruitful, yielding an implementable algorithm with outputs useful for sensitivity analysis. A numerical example is presented.