Suchergebnisse

"October 2, 1998." ; Includes bibliographical references. ; Mode of access: Internet.

OBJECTIVE: Patients using U-500 regular insulin are severely insulin resistant, requiring high doses of insulin. It has been observed that a patient's insulin requirements may dramatically decrease during hospitalization. This study sought to systematically investigate this phenomenon. METHODS: We performed a retrospective chart review of patients with U-500 insulin outpatient regimens who were admitted to the San Antonio Military Medical Center over a 5-year period. Each patient's outpatient total daily dose (TDD) of insulin was compared to the average inpatient TDD. The outpatient estimated average glucose (eAG) was calculated from the glycated hemoglobin (HbA1c) and compared to the average inpatient glucose. RESULTS: There were 27 patients with a total of 62 separate admissions. The average age was 64.4 years, with a mean body mass index of 38.9 kg/m CONCLUSION: U-500 insulin is prone to errors in the hospital setting, so conversion to U-100 insulin is a preferred option. Despite a significant reduction in insulin TDD, these patients had clinically similar glucose levels. Therefore, patients taking U-500 insulin as an outpatient can be converted to a U-100 basal-bolus regimen with at least a 50% reduction of their outpatient TDD. ABBREVIATIONS: BG = blood glucose eAG = estimated average glucose HbA1c = glycated hemoglobin NPO = nil per os SPSS = Statistical Package for the Social Sciences TDD = total daily dose.

One of the most important questions facing scholars of China is how Chinese society is held together. It is now well known that China has been marked by great diversity. In the realm of social customs, not only were there broad regional or class differences, but also, at a local level, the people in one village might adopt a different set of practices from those of neighboring communities. Yet the majority of these varied practices seems to have fit within a frame that was distinctly Chinese. Thus scholars must also ask how people of dissimilar occupations and economic interests, living in widely separated parts of the country, came to recognize and act on a common set of cultural beliefs. Explaining the variations in Chinese society requires minute knowledge of local conditions. Explaining the uniformities requires historical understanding of the processes involved in the spread of ideas and practices and the ways by which some came to be considered standard. Given the available sources on Chinese society, neither of these tasks is simple. The study of kinship and kinship organizations provides one of the best ways to approach the coexisting uniformities and variations of Chinese society. This edited volume is the collaboration of historians and social scientists, and this collaboration is required if we are to learn enough about kinship in Chinese society to explain both the uniformities and the variations. The substantive papers are all written by historians, but these historians have raided the stock of anthropological terms, models, and theories, tried to use technical terms in a consistent and well-defined way, implicitly addressed anthropologists on the issues that seem to fascinate them, and responded to the suggestions and criticisms of the anthropologists who have read their papers. At the same time, however, they remain historians and do not ignore the types of issues (such as historical context and change over time) with which historians have always dealt. The editors believe that this type of collaboration has distinct advantages over the more usual approach to transcending disciplinary boundaries by placing articles by historians and social scientists side by side in the same volume. If we have been successful, social scientists should find issues of interest in the chapters, and historians should find them full of the substance of history and not too long-winded in the belaboring the obvious. This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1986

Altres ajuts: This work was supported by the Minerva Program and the Air Force Office of Scientific Research of the U.S. Department of Defense (AFOSR FA9550-14-1-0030 DEF) and the BIAL Foundation (Grant #163/14). ; Willingness to fight and die (WFD) has been developed as a measure to capture willingness to incur costly sacrifices for the sake of a greater cause in the context of entrenched conflict. WFD measures have been repeatedly used in field studies, including studies on the battlefield, although their neurofunctional correlates remain unexplored. Our aim was to identify the neural underpinnings of WFD, focusing on neural activity and interconnectivity of brain areas previously associated with value-based decision-making, such as the ventromedial prefrontal cortex (vmPFC) and the dorsolateral prefrontal cortex (dlPFC). A sample of Pakistani participants supporting the Kashmiri cause was selected and invited to participate in an functional magnetic resonance (fMRI) paradigm where they were asked to convey their WFD for a series of values related to Islam and current politics. As predicted, higher compared to lower WFD was associated with increased ventromedial prefrontal activity and decreased dorsolateral activity, as well as lower connectivity between the vmPFC and the dlPFC. Our findings suggest that WFD more prominently relies on brain areas typically associated with subjective value (vmPFC) rather than integration of material costs (dlPFC) during decision-making, supporting the notion that decisions on costly sacrifices may not be mediated by cost-benefit computation.

In Resisting Occupation, scholars from around the globe discuss the radical denial of human flourishing caused by the occupation of mind, body, spirit, and land. They explore how religious perspectives can be, and often are, constructed to teach the colonized to want, yearn, and embrace their occupation

Orlova, Bellin, Mummery, and colleagues combined three hiPSC-derived cardiac cell types in 3D microtissues. Cardiomyocytes matured structurally and functionally. Replacing healthy hiPSC-cardiac fibroblasts with patient fibroblasts recapitulated aspects of arrhythmogenic cardiomyopathy. Single-cell transcriptomics, electrophysiology, metabolomics, and ultrastructural analysis revealed roles for CX43 gap junctions and cAMP signaling in the tri-cell-type dialog.Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally immature, but this is improved by incorporation into engineered tissues or forced contraction. Here, we showed that tri-cellular combinations of hiPSC-derived CMs, cardiac fibroblasts (CFs), and cardiac endothelial cells also enhance maturation in easily constructed, scaffold-free, three-dimensional microtissues (MTs). hiPSC-CMs in MTs with CFs showed improved sarcomeric structures with T-tubules, enhanced contractility, and mitochondrial respiration and were electrophysiologically more mature than MTs without CFs. Interactions mediating maturation included coupling between hiPSC-CMs and CFs through connexin 43 (CX43) gap junctions and increased intracellular cyclic AMP (cAMP). Scaled production of thousands of hiPSC-MTs was highly reproducible across lines and differentiated cell batches. MTs containing healthy-control hiPSC-CMs but hiPSC-CFs from patients with arrhythmogenic cardiomyopathy strikingly recapitulated features of the disease. Our MT model is thus a simple and versatile platform for modeling multicellular cardiac diseases that will facilitate industry and academic engagement in high-throughput molecular screening. ; European Research Council (ERCAdG 323182 STEMCARDIOVASC); European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 602423; European Union's Horizon 2020 Research and Innovation Programme under grant agreement no. 668724; Netherlands Organ-on-Chip Initiative, an NWO Gravitation project funded by the Ministry of Education, Culture and Science of the government of the Netherlands; Transnational Research Project on Cardiovascular Diseases (JTC2016_FP-40-021 ACMHF); the Netherlands Organisation for Health Research and Development ZonMW (MKMD project no. 114022504);