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Biobehavioral dispositions can serve as valuable referents for biologically oriented research on core processes with relevance to many psychiatric conditions. The present study examined two such dispositional variables-weak response inhibition (or disinhibition; INH-) and threat sensitivity (or fearfulness; THT+)-as predictors of the serious transdiagnostic problem of suicide risk in two samples: male and female outpatients from a U.S. clinic (N=1078), and a population-based male military cohort from Finland (N=3855). INH- and THT+ were operationalized through scores on scale measures of disinhibition and fear/fearlessness, known to be related to DSM-defined clinical conditions and brain biomarkers. Suicide risk was assessed by clinician ratings (clinic sample) and questionnaires (both samples). Across samples and alternative suicide indices, INH- and THT+ each contributed uniquely to prediction of suicide risk-beyond internalizing and externalizing problems in the case of the clinic sample where diagnostic data were available. Further, in both samples, INH- and THT+ interactively predicted suicide risk, with individuals scoring concurrently high on both dispositions exhibiting markedly augmented risk. Findings demonstrate that dispositional constructs of INH- and THT+ are predictive of suicide risk, and hold potential as referents for biological research on suicidal behavior. ; The research was supported by National Institute of Mental Health Grants MH072850 and MH089727, and U.S. Army Grants W911NF-14-1-0027 and W81XWH-10-2-0181.

Biobehavioral dispositions can serve as valuable referents for biologically oriented research on core processes with relevance to many psychiatric conditions. The present study examined two such dispositional variables-weak response inhibition (or disinhibition; INH-) and threat sensitivity (or fearfulness; THT+)-as predictors of the serious transdiagnostic problem of suicide risk in two samples: male and female outpatients from a U.S. clinic (N=1078), and a population-based male military cohort from Finland (N=3855). INH- and THT+ were operationalized through scores on scale measures of disinhibition and fear/fearlessness, known to be related to DSM-defined clinical conditions and brain biomarkers. Suicide risk was assessed by clinician ratings (clinic sample) and questionnaires (both samples). Across samples and alternative suicide indices, INH- and THT+ each contributed uniquely to prediction of suicide risk-beyond internalizing and externalizing problems in the case of the clinic sample where diagnostic data were available. Further, in both samples, INH- and THT+ interactively predicted suicide risk, with individuals scoring concurrently high on both dispositions exhibiting markedly augmented risk. Findings demonstrate that dispositional constructs of INH- and THT+ are predictive of suicide risk, and hold potential as referents for biological research on suicidal behavior. ; The research was supported by National Institute of Mental Health Grants MH072850 and MH089727, and U.S. Army Grants W911NF-14-1-0027 and W81XWH-10-2-0181.

International audience ; The generation of ultrashort pulses from quantum cascade lasers (QCLs) has proved to be challenging. It has been suggested that the ultrafast electron dynamics of these devices is the limiting factor for modelocking and hence pulse formation. Even so, clear modelocking of terahertz (THz) QCLs has been recently demonstrated but the exact mechanism for pulse generation is not fully understood. Here we demonstrate that the dominant factor necessary for active pulse generation is in fact the synchronization between the propagating electronic modulation and the generated THz pulse in the QCL. By using phase resolved detection of the electric field in QCLs embedded in metal-metal waveguides, we demonstrate that active modelocking requires the phase velocity of the microwave round trip modulation to equal the group velocity of the THz pulse. This allows the THz pulse to propagate in phase with the microwave modulation along the gain medium, permitting short pulse generation. Modelocking was performed on QCLs employing phonon depopulation active regions, permitting coherent detection of large gain bandwidths (500 GHz), and the generation of 11 ps pulses centered around 2.6 THz when the above 'phase-matching' condition is satisfied. This work brings an enhanced understanding of QCL modelocking and will permit new concepts to be explored to generate shorter and more intense pulses from mid-infrared, as well as THz, QCLs.

International audience ; The generation of ultrashort pulses from quantum cascade lasers (QCLs) has proved to be challenging. It has been suggested that the ultrafast electron dynamics of these devices is the limiting factor for modelocking and hence pulse formation. Even so, clear modelocking of terahertz (THz) QCLs has been recently demonstrated but the exact mechanism for pulse generation is not fully understood. Here we demonstrate that the dominant factor necessary for active pulse generation is in fact the synchronization between the propagating electronic modulation and the generated THz pulse in the QCL. By using phase resolved detection of the electric field in QCLs embedded in metal-metal waveguides, we demonstrate that active modelocking requires the phase velocity of the microwave round trip modulation to equal the group velocity of the THz pulse. This allows the THz pulse to propagate in phase with the microwave modulation along the gain medium, permitting short pulse generation. Modelocking was performed on QCLs employing phonon depopulation active regions, permitting coherent detection of large gain bandwidths (500 GHz), and the generation of 11 ps pulses centered around 2.6 THz when the above 'phase-matching' condition is satisfied. This work brings an enhanced understanding of QCL modelocking and will permit new concepts to be explored to generate shorter and more intense pulses from mid-infrared, as well as THz, QCLs.

International audience ; The generation of ultrashort pulses from quantum cascade lasers (QCLs) has proved to be challenging. It has been suggested that the ultrafast electron dynamics of these devices is the limiting factor for modelocking and hence pulse formation. Even so, clear modelocking of terahertz (THz) QCLs has been recently demonstrated but the exact mechanism for pulse generation is not fully understood. Here we demonstrate that the dominant factor necessary for active pulse generation is in fact the synchronization between the propagating electronic modulation and the generated THz pulse in the QCL. By using phase resolved detection of the electric field in QCLs embedded in metal-metal waveguides, we demonstrate that active modelocking requires the phase velocity of the microwave round trip modulation to equal the group velocity of the THz pulse. This allows the THz pulse to propagate in phase with the microwave modulation along the gain medium, permitting short pulse generation. Modelocking was performed on QCLs employing phonon depopulation active regions, permitting coherent detection of large gain bandwidths (500 GHz), and the generation of 11 ps pulses centered around 2.6 THz when the above 'phase-matching' condition is satisfied. This work brings an enhanced understanding of QCL modelocking and will permit new concepts to be explored to generate shorter and more intense pulses from mid-infrared, as well as THz, QCLs.

Context Migratory species are known to pose a challenge for conservation because it is essential to understand their complex life history in order to implement efficient conservation actions. Aims In New Caledonia, large seagrass habitats in the Grand Lagon Sud (GLS) are home to resident green turtles (Chelonia mydas) of unknown origins. To assess the stock composition in the GLS, 164 foraging turtles were sampled for genetic analysis of ~770 base pairs of the mitochondrial DNA (mtDNA) control region. Methods Foraging turtles ranging in size from 48.0 to 108.4 cm curved carapace length were captured at five different sites within the GLS between September 2012 and December 2013. To provide baseline data for mixed stock analysis, published data from rookeries were used in addition to 105 samples collected at rookeries in the d'Entrecasteaux Islands and Chesterfield Islands in New Caledonia and at Malekula Island in Vanuatu. Exact tests of population differentiation and pairwise FST estimates were used to test for differences in mtDNA haplotype frequencies. Key results These analyses indicated that rookeries in the d'Entrecasteaux Islands and Vanuatu form unique management units and that the Chesterfield Islands rookeries are linked to the Coral Sea management unit. Mixed stock analysis indicated the highest proportion (mean = 0.63) of foraging turtles originate from the d'Entrecasteaux stock. Conclusions The larger contribution is estimated to be from a large rookery from New Caledonia, but smaller contributions are suggested from other rookeries in the South Pacific. Implications Marine conservation policies in New Caledonia need to consider the links between the foraging and nesting populations of C. mydas in New Caledonia and other rookeries and foraging grounds in the Coral Sea.

IntroductionMother‐to‐child transmission of HIV can be reduced to<5% with appropriate antiretroviral medications. Such reductions depend on multiple health system encounters during antenatal care (ANC), delivery and breastfeeding; in countries with limited access to care, transmission remains high. In Lesotho, where 28% of women attending ANC are HIV positive but where geographic and other factors limit access to ANC and facility deliveries, a Minimum PMTCT Package was launched in 2007 as an alternative to the existing facility‐based approach. Distributed at the first ANC visit, it packaged together all necessary pregnancy, delivery and early postnatal antiretroviral medications for mother and infant.MethodsTo examine the availability, feasibility, acceptability and possible negative consequences of the Minimum PMTCT Package, data from a 2009 qualitative and quantitative study and a 2010 facility assessment were used. To examine the effects on ANC and facility‐based delivery rates, a difference‐in‐differences analytic approach was applied to 2009 Demographic and Health Survey data for HIV‐tested women who gave birth before and after Minimum PMTCT Package implementation.ResultsThe Minimum PMTCT Package was feasible and acceptable to providers and clients. Problems with test kit and medicine stock‐outs occurred, and 46% of women did not receive the Minimum PMTCT Package until at least their second ANC visit. Providing adequate instruction on the use of multiple medications represented a challenge. The proportion of HIV‐positive women delivering in facilities declined after Minimum PMTCT Package implementation, although it increased among HIV‐negative women (difference‐in‐differences=14.5%, p=0.05). The mean number of ANC visits declined more among HIV‐positive women than among HIV‐negative women after implementation, though the difference was not statistically significant (p=0.09). Changes in the percentage of women receiving≥4 ANC visits did not differ between the two groups.ConclusionsIf supply issues can be resolved and adequate client educational materials provided, take‐away co‐packages have the potential to increase access to PMTCT commodities in countries where women have limited access to health services. However, efforts must be made to carefully monitor potential changes in ANC visits and facility deliveries, and further evaluation of adherence, safety and effectiveness are needed.

IntroductionIn 2004, Mozambique, supported by large increases in international disease‐specific funding, initiated a national rapid scale‐up of antiretroviral treatment (ART) and HIV care through a vertical "Day Hospital" approach. Though this model showed substantial increases in people receiving treatment, it diverted scarce resources away from the primary health care (PHC) system. In 2005, the Ministry of Health (MOH) began an effort to use HIV/AIDS treatment and care resources as a means to strengthen their PHC system. The MOH worked closely with a number of NGOs to integrate HIV programs more effectively into existing public‐sector PHC services.Case DescriptionIn 2005, the Ministry of Health and Health Alliance International initiated an effort in two provinces to integrate ART into the existing primary health care system through health units distributed across 23 districts. Integration included: a) placing ART services in existing units; b) retraining existing workers; c) strengthening laboratories, testing, and referral linkages; e) expanding testing in TB wards; f) integrating HIV and antenatal services; and g) improving district‐level management. Discussion: By 2008, treatment was available in nearly 67 health facilities in 23 districts. Nearly 30,000 adults were on ART. Over 80,000 enrolled in the HIV/AIDS program. Loss to follow‐up from antenatal and TB testing to ART services has declined from 70% to less than 10% in many integrated sites. Average time from HIV testing to ART initiation is significantly faster and adherence to ART is better in smaller peripheral clinics than in vertical day hospitals. Integration has also improved other non‐HIV aspects of primary health care.ConclusionThe integration approach enables the public sector PHC system to test more patients for HIV, place more patients on ART more quickly and efficiently, reduce loss‐to‐follow‐up, and achieve greater geographic HIV care coverage compared to the vertical model. Through the integration process, HIV resources have been used to rehabilitate PHC infrastructure (including laboratories and pharmacies), strengthen supervision, fill workforce gaps, and improve patient flow between services and facilities in ways that can benefit all programs. Using aid resources to integrate and better link HIV care with existing services can strengthen wider PHC systems.