Suchergebnisse

Molecular dynamics simulation (MD) is, just behind genomics, the bioinformatics tool that generates the largest amounts of data, and that is using the largest amount of CPU time in supercomputing centres. MD trajectories are obtained after months of calculations, analysed in situ, and in practice forgotten. Several projects to generate stable trajectory databases have been developed for proteins, but no equivalence exists in the nucleic acids world. We present here a novel database system to store MD trajectories and analyses of nucleic acids. The initial data set available consists mainly of the benchmark of the new molecular dynamics force-field, parmBSC1. It contains 156 simulations, with over 120 of total simulation time. A deposition protocol is available to accept the submission of new trajectory data. The database is based on the combination of two NoSQL engines, Cassandra for storing trajectories and MongoDB to store analysis results and simulation metadata. The analyses available include backbone geometries, helical analysis, NMR observables and a variety of mechanical analyses. Individual trajectories and combined meta-trajectories can be downloaded from the portal. The system is accessible through http: //mmb.irbbarcelona.org/BIGNASim/. Supplementary Material is also available on-line at http://mmb. irbbarcelona.org/BIGNASim/SuppMaterial/. ; Spanish Ministry of Science [BIO2012-32868, SEV-2011-00067, TIN2012-34557]; Catalan Government [2014-SGR-134, 2014-SGR-1051]; Institut Català de Recerca I Estudis Avanc¸ats, ICREA Academia [to M.O.], Instituto de Salud Carlos III-Instituto Nacional de Bioinformática [PT13/0001/0019, PT13/0001/0028]; European Research Council [ERC SimDNA]; European Union, H2020 programme [Elixir-Excellerate: 676559; BioExcel: 674728, MuG: 676566]; PEDECIBA and SNI (ANII, Uruguay) [to P.D.D.]. Funding for open access charge: European Union [MuG: 676566]. ; Peer Reviewed ; Postprint (published version)

Molecular dynamics simulation (MD) is, just behind genomics, the bioinformatics tool that generates the largest amounts of data, and that is using the largest amount of CPU time in supercomputing centres. MD trajectories are obtained after months of calculations, analysed in situ, and in practice forgotten. Several projects to generate stable trajectory databases have been developed for proteins, but no equivalence exists in the nucleic acids world. We present here a novel database system to store MD trajectories and analyses of nucleic acids. The initial data set available consists mainly of the benchmark of the new molecular dynamics force-field, parmBSC1. It contains 156 simulations, with over 120 of total simulation time. A deposition protocol is available to accept the submission of new trajectory data. The database is based on the combination of two NoSQL engines, Cassandra for storing trajectories and MongoDB to store analysis results and simulation metadata. The analyses available include backbone geometries, helical analysis, NMR observables and a variety of mechanical analyses. Individual trajectories and combined meta-trajectories can be downloaded from the portal. The system is accessible through http: //mmb.irbbarcelona.org/BIGNASim/. Supplementary Material is also available on-line at http://mmb. irbbarcelona.org/BIGNASim/SuppMaterial/. ; Spanish Ministry of Science [BIO2012-32868, SEV-2011-00067, TIN2012-34557]; Catalan Government [2014-SGR-134, 2014-SGR-1051]; Institut Català de Recerca I Estudis Avanc¸ats, ICREA Academia [to M.O.], Instituto de Salud Carlos III-Instituto Nacional de Bioinformática [PT13/0001/0019, PT13/0001/0028]; European Research Council [ERC SimDNA]; European Union, H2020 programme [Elixir-Excellerate: 676559; BioExcel: 674728, MuG: 676566]; PEDECIBA and SNI (ANII, Uruguay) [to P.D.D.]. Funding for open access charge: European Union [MuG: 676566]. ; Peer Reviewed ; Postprint (published version)

Anhand der Vorarbeiten zu einem historischen Atlas der Siedlungen und Gräberfelder der Römischen Kaiserzeit skizziert der Autor den Aufbau eines Informationssystems für Archäologen, das sowohl für Ausgrabungspläne als auch für Museen genutzt werden kann. Dieses System erlaubt dem Nutzer, archäologische Quellen jeglicher Art zu strukturieren und zu bewerten. Im Zentrum der Ausführungen stehen die technischen Aspekte der Entwicklung des ADS (Archaeological Datebase System). Die 'CASE-Method' (Computer Aided Systems Engineering) wird zum Aufbau der organisatorischen Aspekte eines solchen Systems herangezogen. (pmb)

This article introduces the Polity IIId ("d" is for dates) data set. The Polity IIId project codes the precise dates of changes in political structure identified by Polity III for all independent countries in the international system from 1800 to 1994. By moving from annual measurements of authority and polity characteristics, the Polity IIId data are more appropriate for event-based analysis. The authors discuss the implications of the new data set for event count and event history models of democracy and war, democratization and war, regime type and civil war, and causes of change in political structure.

The main objective of IEA R&D Wind Annex XVII - Database on Wind Characteristics - has been to provide wind energy planners, designers and researchers, as well as the international wind engineering community in general, with a source of actual wind fielddata (time series and resource data) observed in a wide range of different wind climates and terrain types. Connected to an extension of the initial Annex period, the scope for the continuation was widened to include also support to the international windturbine standardisation efforts. The project partners are Sweden, Norway, U.S.A., The Netherlands and Denmark, with Denmark as the Operating Agent. The reporting of the continuation of Annex XVII falls in two separate parts. Part one accounts in detailsfor the available data in the established database bank, and part two describes various data analyses performed with the overall purpose of improving the design load cases with relevance for to wind turbine structures. The present report constitutes thesecond part of the Annex XVII reporting. Both fatigue and extreme load aspects are dealt with, however, with the main emphasis on the latter. The work has been supported by The Ministry of Environment and Energy, Danish Energy Agency, The NetherlandsAgency for Energy and the Environment (NOVEM), The Norwegian Water Resources and Energy Administration (NVE), The Swedish National Energy Administration (STEM) and The Government of the United States of America.

Material usage and the related embodied environmental impact have grown in significance in the built environment. Therefore, cities and governments need to develop strategies to reduce both the consumption of resources during usage phase as well as the embodied impact of the current building stock. This article proposes a new component-based building inventory database as a basis to develop such strategies using building stock modeling. The developed database clusters the building stock according to building typology (single-family houses, multifamily houses, and office buildings), age, and the main construction systems of the different building components. Based on the component makeup, it lists the necessary material input and waste output for different refurbishment options for each building component. The advantages of the proposed database structure are shown based on two applications for the developed database for Switzerland. The component-based database allows optimization of refurbishment strategies not only from an energetic perspective, but also with respect to materials, both on the input (sourcing of materials) and the output (waste streams) level. The database structure makes it possible to continuously extend the data set by adding new refurbishment options or add data such as component-specific lifetimes, costs, or labor intensities of the refurbishment options. In combination with an aligned economic model, this would give an even more holistic view, impact, and feasibility of different refurbishment scenarios both in environmental and economic terms. ; ISSN:1088-1980 ; ISSN:1530-9290

Familienpolitik in Westeuropa im internationalen Vergleich.
Institutionelle Regelungen (Verordnungen und Gesetze) und quantitative
Kennzahlen für die einzelnen Länder in Form von Aggregatzahlen in einer
Datenbank mit Zeitreihen auf jährlicher Basis.

Themen: I. Zeitreihendaten 1. Allgemeine Familienbeihilfen: Höhe von
Unterstützungsleistungen; altersabhängige Zusatzzahlungen und solche
für behinderte Kinder; Zuwendungen für Kinder (Kindergeld); Zuwendungen
für Familien bzw. Haushalte: Gesamtzahl der zuwendungsberechtigten
Familien bzw. Haushalte; Aufwendungsstruktur (Gesamtaufwendungen und
Art der zweckgebundenen Aufwendungen); Finanzierungsstruktur:
Gesamteinnahmen und Art der Finanzierungsquellen.

2. Geldleistungen für Ein-Eltern-Familien (Alleinerziehende)

3. Transferleistungen zur Sicherung des Existenzminimums: Zahlungshöhe
der Unterstützungsleistungen; Unterstützungszahlungen für besondere
Bedürfnisse; Art dieser Bedürfnisse; Zahlungsempfänger (Gesamtzahl
Personen, Kinder und Familien bzw. Haushalte); Aufwendungsstruktur
(Gesamtaufwendungen und Art der zweckgebundenen Aufwendungen);
Finanzierungsstruktur (Gesamteinnahmen und Art der
Finanzierungsquellen).

4. Familienbeihilfen für Kurzzeitpflege bzw. Langzeitpflege: Höhe der
Unterstützungsleistungen; Unterstützungszahlungen für
unterhaltsberechtigte Erwachsene sowie für Kinder und niedrige
Einkommensgruppen; Gesamtanzahl der Zuwendungsempfänger sowie der
Kinder, Erwachsenen und Älteren; Kinder in Zwei- bzw.
Ein-Eltern-Haushalten; Haushaltsstruktur der älteren
Zuwendungsempfänger; Gesamtanzahl der empfangsberechtigten Familien
bzw. Haushalte und Anzahl der Kinder im Haushalt; Aufwendungsstruktur
(Gesamtaufwendungen und Art der zweckgebundenen Aufwendungen);
Finanzierungsstruktur (Gesamteinnahmen und Art der
Finanzierungsquellen).

5. Angebot an Kinderbetreuungseinrichtungen: Gesamtanzahl der
Kinderbetreuungseinrichtungen; Art der Betreuungseinrichtung und der
Trägerschaft; Gesamtanzahl und Art der zur Verfügung stehenden
Betreuungsplätze; Anzahl des beschäftigten Personals und Trägerschaft;
Beschäftigungsverhältnis; Höhe des Arbeitsentgelts; Vollzeit- oder
Teilzeitbeschäftigung; Anzahl der betreuten Kinder und Träger der
Einrichtung; Altersstruktur der Kinder; Aufwendungsstruktur (Höhe der
Gesamtaufwendungen sowie von den Trägern aufgewandte Summe für die
Kinderbetreuung; zweckgebundene Aufwendungen; Finanzierungsstruktur
(Gesamteinnahmen und Art der Finanzierungsquellen.

6. Geldleistungen und zeitliche Ansprüche für die Pflege von Familien-
bzw. Haushaltsmitgliedern: Geschlecht und Anzahl der Zahlungsempfänger;
berufliche Stellung und Beschäftigungsverhältnis der Zahlungsempfänger;
Nutzungsdauer.

II. Informationen über institutionelle Bestimmungen für allgemeine
Familienbeihilfen: Gesetzesgrundlage; Gesetzesebene; finanziell
verantwortliche Behörde; nationale, regionale oder lokale Ebene der
finanziellen Trägerschaft; Finanzierungsquellen;
Berechtigungsvoraussetzungen; Einkommens- und Versicherungspflichtgrenzen;
Bedürftigkeitsprüfung; Beihilfevorschriften; Versteuerung der Beihilfe.

This paper describes the Macroprudential Database (MPDB) of the European Central Bank (ECB), which is an important component of the ECB's Statistical Data Warehouse. After explaining the rationale for creating the MPDB, the paper illustrates how it supports the macroprudential analysis conducted by the European System of Central Banks (ESCB), the European Systemic Risk Board (ESRB) and the national authorities of the Single Supervisory Mechanism (SSM) and the European Union. The structure of the database and a broad overview of available indicators are then presented, with a description of the relevant confidentiality issues. Examples illustrate how the MPDB is used for monitoring purposes and econometric modelling. Finally, the paper discusses remaining data gaps and expected future enhancements of the database.

The paper investigates the issue of the optimal number of alternatives that should be placed on database menu pages. A previous search-time model (Lee and MacGregor, 1985) is extended by proposing a criterion-based decision model, which makes predictions about how the number of alternatives affects the search process and the pattern of errors that will result. An experimental test of the model largely supported the predictions and indicated that with naive users the optimal number of alternatives per page is four to five. These values resulted in the shortest search times, the highest success rates, and the highest preference rankings.