SBML qualitative models: a model representation format and infrastructure to foster interactions between qualitative modelling formalisms and tools
Qualitative frameworks, especially those based on the logical discrete formalism, are increasingly used to model regulatory and signalling networks. A major advantage of these frameworks is that they do not require precise quantitative data, and that they are well-suited for studies of large networks. While numerous groups have developed specific computational tools that provide original methods to analyse qualitative models, a standard format to exchange qualitative models has been missing. ; Nebraska NASA Space Grant Consortium grant: ("Technology for collaborative biomedical research"), National Institutes of Health grant support: (#5R01DA030962), US National Institute of General Medical Sciences support: (#GM070923), Swiss Federal Government through the Federal Office of Education Science and Innovation (SERI) and the European Commission FP6 project ENFIN (Experimental Network for Functional INtegration–LSHG-CT-2005-518254), FCT grant: (Pest-OE/EEI/LA002), , Federal Ministry of Education and Research (BMBF, Germany) as part of the Virtual Liver Network grants : (0315756, 0315744), EMBL-EBI.