Suchergebnisse

7 páginas, 2 tablas, 1 figura. ; The Stopping Transmission Of intestinal Parasites (STOP) project is part of the EDCTP2 programme supported by the European Union (grant number RIA2017NCT-1845 — STOP). JG is personally supported by Ramon Areces Foundation, Spain; MMV by the Spanish 'Ramón y Cajal' Programme, Ministry of Economy and Competitiveness (RYC-2015-18368); and SK is supported by DELTAS Africa Initiative grant # DEL15-011 to THRiVE-2. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

12 páginas, 3 tablas, 3 figuras. ; There is an urgent need for an extensive evaluation of benzimidazole efcacy in humans. In veterinary science, benzimidazole resistance has been mainly associated with three single-nucleotide polymorphisms (SNPs) in the isotype-1 β-tubulin gene. In this study, we optimized the stool sample processing methodology and resistance allele frequency assessment in Trichuris trichiura and Necator americanus anthelmintic-related SNPs by pyrosequenc‑ ing, and standardized it for large-scale benzimidazole efcacy screening use. ; This study was funded by the 'Stopping Transmission Of intestinal Parasites (STOP)' project (EDCTP2 programme supported by the European Union; RIA2017NCT-1845-STOP). JG was personally supported at the beginning of the work by the Ramón Areces Foundation and is now funded by the Spanish 'Juan de la Cierva' Programme, Ministry of Economy and Competitiveness (FJC-2018-38305). MCP is supported by the Junta de Castilla y León and Fondo Social Europeo, and MMV by the Spanish 'Ramón y Cajal' Programme, Ministry of Economy and Competitiveness (RYC-2015-18368). ; Peer reviewed