Suchergebnisse

AbstractWe draw upon impression management theory and cognitive dissonance theory to examine whether or not corporate hypocrisy triggers substantial environmental, social, and governance (ESG) rating divergence and to further investigate the influence channels of cognitive dissonance and impression management. In addition, our study explores the moderating role of media coverage with different emotional biases in shaping the relationship between corporate hypocrisy and ESG rating divergence. By utilizing a comprehensive dataset comprising 3562 Chinese listed companies and 25,898 firm‐year observations from 2010 to 2022, findings reveal that hypocritical firms exhibit significantly large ESG rating divergence. In particular, these firms induce cognitive dissonance among rating agencies, resulting in rating disparities, which are further magnified when using impression management through the selective disclosure of negative information or symbolic promotion of positive information. Furthermore, positive media coverage weakens the positive association between corporate hypocrisy and ESG rating divergence, whereas negative media coverage strengthens this relationship. Lastly, we find that the impact of corporate hypocrisy on ESG rating divergence is more pronounced for companies with higher average ESG scores, lower long‐term charitable involvement, and lower information opacity. These findings withstand various sensitivity tests utilizing alternative measures for rating divergence and corporate hypocrisy, as well as different sample compositions. Our conclusions remain robust even after addressing endogeneity concerns using a two‐stage least squares regression model.

Xiang Zhu,1,2,* An Xu,3,* Yang Zhang,4,* Nan Huo,2 Rui Cong,2 Luyuan Ma,2 Zhong Chu,2 Zhi Tang,2 Xiaofeng Kang,2 Shaozhong Xian,5 Xiaojie Xu2 1Department of Infectious Disease, Army No.82 Group Military Hospital, Baoding, People's Republic of China; 2Department of Cellular Engineering Lab, Beijing Institute of Biotechnology, Beijing, People's Republic of China; 3Department of Oncology, Second Medical Center of Chinese PLA General Hospital, Beijing, People's Republic of China; 4Department of Radiation Oncology, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi, People's Republic of China; 5Department of Urology, Beijing Luhe Hospital, Capital Medical University, Beijing, People's Republic of China*These authors contributed equally to this workCorrespondence: Xiaojie Xu; Shaozhong Xian Email miraclexxj@126.com; hsn820628@163.comBackground: Renal cell cancer (RCC) is one of the most lethal malignancies of the kidney in adults. mTOR (mammalian target of rapamycin) signaling pathway plays a pivotal role in RCC tumorigenesis and progression and inhibitors targeting the mTOR pathway have been widely used in advanced RCC treatment. Therefore, it is of great significance to explore the potential regulators of the mTOR pathway as RCC therapeutic targets.Materials and Methods: Bioinformatics analysis was used to screen out the most significant differentially expressed genes in the RCC dataset of The Cancer Genome Atlas (TCGA). Real-time PCR and Western-blot analysis were utilized to examine the expression of inositol-1,4,5-trisphosphate-3-kinase-A (ITPKA) in four RCC cell lines and one human embryonic kidney cell line. Cell counting Kit-8 and colony formation assay were performed to estimate the effect of ITPKA on the proliferation ability of RCC cells. Wound healing and Transwell assays were used to test the effect of ITPKA on RCC cell migration and invasion. Xenograft formation assay was performed in nude mice to investigate the effect of ITPKA in vivo. mTORC1 pathway inhibitor was added to explore the mechanisms by which ITPKA regulates RCC cell growth and progression.Results: Based on bioinformatics analysis, ITPKA is screened out as one of the most significant differentially expressed genes in RCC. ITPKA is upregulated and positively correlated with RCC malignancy and poorer prognosis. ITPKA promotes RCC growth, migration and invasion in cultured cells, and accelerates tumor growth in nude mice. Mechanistically, ITPKA stimulates the mTORC1 signaling pathway which is a requirement for ITPKA modulation of RCC cell proliferation, migration and invasion.Conclusion: Our data demonstrate a critical regulatory role of the ITPKA in RCC and suggest that ITPKA/mTORC1 axis may be a promising target for diagnosis and treatment of RCC.Keywords: ITPKA1, RCC, growth, migration and invasion, mTORC1 pathway

Purpose Healthcare professionals experience stressors that begin during training and persist into their careers that adversely impact their well-being. This study aims to identify students' and professionals' stress levels, satisfaction with wellness domains, barriers to wellness, and stress management practices. Design This study was a cross-sectional self-reported survey study. Settings and Sample The study included students (N = 242) and professionals (N = 237) from medicine, nursing, pharmacy, physical therapy, social work, and counseling/psychology. Measures The Managing Health & Wellness in Health Professions Training and Practice survey was used to capture wellness practices and barriers among participants. Results: Students reported significantly higher perceived stress compared to professionals ( P < 0.001). Total wellness is significantly higher among professionals compared to students ( P < 0.001). A higher stress rate is significantly related to being female, having a lower wellness score, and facing more barriers ( P < 0.001). Intellectual health is the most valuable wellness domain for providers (M = 3.71, SD = 0.9) and students (M = 3.43, SD = 0.85), followed by spiritual health for providers (M = 3.4, SD = 1.1), and work/learning environment for students (M = 3.33, SD = 0.93). Professionals and students are least satisfied with their physical and financial health. Barriers include fatigue, workload/productivity in clinical practice, work hours, and burnout. Conclusions Healthcare professionals exhibit a variety of stress management practices, encounter barriers, and prioritize different wellness domains. Healthcare systems should incorporate self-care education into their curricula and implement systemic changes to foster a thriving healthcare workforce.