13 Ergebnisse
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In: Progress in nuclear energy: the international review journal covering all aspects of nuclear energy, Band 146, S. 104144
ISSN: 0149-1970
In: Progress in nuclear energy: the international review journal covering all aspects of nuclear energy, Band 120, S. 103213
ISSN: 0149-1970
In: EEB-D-24-00844
SSRN
SSRN
In: Progress in nuclear energy: the international review journal covering all aspects of nuclear energy, Band 168, S. 104987
ISSN: 0149-1970
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 235, S. 113430
ISSN: 1090-2414
In: Environmental science and pollution research: ESPR, Band 27, Heft 20, S. 25461-25474
ISSN: 1614-7499
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 278, S. 116354
ISSN: 1090-2414
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 241, S. 113852
ISSN: 1090-2414
In: Environmental science and pollution research: ESPR, Band 23, Heft 17, S. 17191-17199
ISSN: 1614-7499
In: info:eu-repo/semantics/altIdentifier/doi/10.2147/IJN.S206294
Shurui Zhao,1 Ze Li,1 Fei Huang,2 Jianhui Wu,1 Lin Gui,1 Xiaoyi Zhang,1 Yaonan Wang,1 Xiaozhen Wang,1 Shiqi Peng,1 Ming Zhao11Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Beijing Laboratory of Biomedical Materials, College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, People's Republic of China; 2Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, People's Republic of ChinaBackground: In vitro (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxyl-Lys(Pro-Ala-Lys)-Arg-Gly-Asp-Val (MTCA-KKV) adheres activated platelets, targets P-selectin and GPIIb/IIIa. This led to the development of MTCA-KKV as thrombus targeting nano-medicine.Methods: MTCA-KKV was characterized by nano-feature, anti-thrombotic activity, thrombolytic activity, thrombus target and targeting release.Results: In vivo 0.01 μmol/kg of MTCA-KKV formed nano-particles less than 100 nm in diameter, targeted thrombus, released anti-thrombotic and thrombolytic pharmacophores, prevented thrombosis and dissolved blood clots.Conclusion: Based on the profiles of targeting thrombus, targeting release, inhibiting thrombosis and dissolving blood clots MTCA-KKV is a promising nano-medicine.Keywords: nano-particles, anti-thrombotic, thrombolytic, targeting, release
BASE
In: STOTEN-D-22-18799
SSRN
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 225, S. 112743
ISSN: 1090-2414
