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Introduction: Queer Sinophone Studies: Intellectual Synergies / Howard Chiang and Alvin K. Wong -- Transpacific: Transfiguring Asian North America and the Sinophonic in Jia Qing Wilson-Yang's Small Beauty / Lily Wong -- Viscerality: Choreographies of the Flesh: The Geopolitics of Visceral Violence in Warriors of the Rainbow: Seediq Bale (2011) / Jih-Fei Cheng -- Postcoloniality: Postcoloniality beyond China-centrism: Queer Sinophone Transnationalism in Hong Kong Cinema / Alvin K. Wong -- Ethnicity: A Queerness of Relation: The Plight of the Ethnic Minority in Chan Koon-Chung's Bare Life / Kyle Shernuk -- Liminality: So Happy Together -- Too: Contemporary Philippine Gay Comedy and the Queering of Chinese-Filipino Liminality / M. Atonio Lizida -- Fandom: Transcultural Desires and Lesbian Fandom: Takarazuka Revue in Taiwan / Lucetta Y. L. Kam -- Adaptation: Recognition, Reproach, Repression: The Ren Likui Case in 1947 Tianjin and the Cultural Politics of Homosexual Murder in the Sinophone World / Mian Chen -- Intermediality: A Weird Concept: Queer Intermediality in Dung Kai-cheung's Fiction / Carlos Rojas -- Activism: Language, Class, and the Hoenggong-Gwailou Divide in Hong Kong LGBTI Activism / Nathan Madson -- Residual: The Polite Residuals of Heteronormativity: Legalizing Transgender Marriage from the European Court of Human Rights to Sinophone Hong Kong / Howard Chiang.

BACKGROUND: Disabled People's Organisations (DPOs) are the mainstay of disability responses worldwide. Yet there is no quantitative data assessing their effectiveness in low-and middle-income countries (LMICs). The aim of this study was to measure the effectiveness of DPOs as a low-cost intervention to improve well-being and access to services and facilities for people with disabilities. METHODS: We undertook a cluster randomised intervention control trial across 39 distinct rural villages in Uttarakhand State, North India. A total of 527 participants were included from 39 villages: 302 people from 20 villages were assigned to the intervention arm and 225 from 19 villages were assigned to the control group. Over a 2-year period, people with disabilities were facilitated to form DPOs with regular home visits. Participants were also given financial support for public events and exposure visits to other DPOs. Seven domains were used to measure access and participation. RESULTS: DPO formation had improved participation in community consultations (OR 2.57, 95% CI 1.4 to 4.72), social activities (OR 2.46, 95% CI 1.38 to 4.38), DPOs (OR 14.78, 95% CI 1.43 to 152.43), access to toilet facilities (OR 3.89, 95% CI 1.31 to 11.57), rehabilitation (OR 6.83, 95% CI 2.4 to 19.42) and Government social welfare services (OR 4.82, 95% CI 2.35 to 9.91) in intervention when compared to the control. People who were part of a DPO had an improvement in having their opinion heard (OR 1.94, 95% CI 1.16 to 3.24) and being able to make friends (OR 1.63, 95% CI 1 to 2.65) compared to those who were not part of a DPO. All other well-being variables had little evidence despite greater improvement in the DPO intervention group. CONCLUSIONS: This is the first randomised control trial to demonstrate that DPOs in LMICs are effective at improving participation, access and well-being. This study supports the ongoing role of DPOs in activities related to disability inclusion and disability services. This study also suggests that supporting the establishment, facilitation and strengthening of DPOs is a cost-effective intervention and role that non-governmental organisations (NGOs) can play. TRIAL REGISTRATION: ISRCTN36867362, 9th Oct 2019 (retrospectively registered).

AbstractIntroduction: In accordance with global testing and treatment targets, many countries are seeking ways to reach the "90‐90‐90" goals, starting with diagnosing 90% of all people with HIV. Quality HIV testing services are needed to enable people with HIV to be diagnosed and linked to treatment as early as possible. It is essential that opportunities to reach people with undiagnosed HIV are not missed, diagnoses are correct and HIV‐negative individuals are not inadvertently initiated on life‐long treatment. We conducted this systematic review to assess the magnitude of misdiagnosis and to describe poor HIV testing practices using rapid diagnostic tests.Methods: We systematically searched peer‐reviewed articles, abstracts and grey literature published from 1 January 1990 to 19 April 2017. Studies were included if they used at least two rapid diagnostic tests and reported on HIV misdiagnosis, factors related to potential misdiagnosis or described quality issues and errors related to HIV testing.Results: Sixty‐four studies were included in this review. A small proportion of false positive (median 3.1%, interquartile range (IQR): 0.4‐5.2%) and false negative (median: 0.4%, IQR: 0‐3.9%) diagnoses were identified. Suboptimal testing strategies were the most common factor in studies reporting misdiagnoses, particularly false positive diagnoses due to using a "tiebreaker" test to resolve discrepant test results. A substantial proportion of false negative diagnoses were related to retesting among people on antiretroviral therapy.Conclusions: HIV testing errors and poor practices, particularly those resulting in false positive or false negative diagnoses, do occur but are preventable. Efforts to accelerate HIV diagnosis and linkage to treatment should be complemented by efforts to improve the quality of HIV testing services and strengthen the quality management systems, particularly the use of validated testing algorithms and strategies, retesting people diagnosed with HIV before initiating treatment and providing clear messages to people with HIV on treatment on the risk of a "false negative" test result.

Manitoba is home to approximately 1,500 Inuit, and sees 16,000 consults yearly from the Kivalliq region of Nunavut to access services. The purpose of our study was to develop detailed profiles of Inuit accessing services in Manitoba, by using administrative data routinely collected by Manitoban agencies, to support the development of Inuit-centric services. This study was conducted in partnership with the Manitoba Inuit Association, and Inuit Elders from Nunavut and Manitoba. Findings shows that the Inuit community living in Manitoba is fairly stable, with only approximately 5 percent of Inuit moving in and out of Manitoba on any given year. Inuit settle primarily in Winnipeg, and a significant proportion depend on social programs such as Income Assistance and housing support. A significant number of Inuit children have contact with the Child Welfare System. Our results support the need for more Inuit-centric programming, including family support and language programs.

Thoracic aortic calcium (TAC) has been associated with a higher prevalence of coronary arterial calcium (CAC). The purpose of this study was to assess the relationship between TAC with both incident CAC and CAC progression in a cohort from the Multi-Ethnic Study of Atherosclerosis (MESA). MESA is a prospective cohort study of 6,814 participants free of clinical cardiovascular disease at entry who underwent non-contrast cardiac computed tomography scanning at baseline examination and at a 2 year follow up. We investigated the independent association between TAC and incident CAC among those without CAC at baseline and between TAC and CAC progression among those with CAC at baseline. The final study population consisted of 5,755 (84%) individuals (62±10 years, 48% males) who had a follow up CAC score an average of 2.4 years later. Incident CAC was significantly higher among those with TAC versus without TAC at baseline (11 per 100 person years versus 6 per 100 person years). Similarly, TAC was associated with a higher CAC change (p<0.0001) in those with some CAC at baseline. In demographic & follow-up duration adjusted analysis, TAC was associated with both incident CAC (RR 1.72; P < 0.0001) as well as with a greater CAC change (RR for 1(st) and 4(th) quartiles and 95% CI: RR 2.89; −3.16, 8.95; RR 24.21; 18.25, 30.18. In conclusion, TAC is associated with incidence and progression of CAC. Detection of TAC may improve risk stratification efforts. Future clinical outcomes studies are needed to support such approach.

Non-communicable diseases, particularly cardiovascular diseases, are the leading cause of decreased life expectancy and death in Latin America and the Caribbean. Although a lifestyle, which includes no tobacco use, good nutrition, and regular physical activity is touted as key to health, the environmental, racial, social and economic conditions, which underpin lifestyle are often ignored or considered only secondarily. Placing the main responsibility on a patient to change their lifestyle or to simply comply with pharmacological treatment ignores the specific conditions in which the individual lives. Furthermore, there are major disparities in access to both healthy living conditions as well as access to medical care.There is sufficient evidence to support advocating for policies that support healthy living, particularly healthy food choices. Progress is being made to improve the food environment with enactment of front of package nutritional labels. However, policies were enacted only after intense regional research and advocacy supporting their implementation.Government officials must rise above the pressures of commercial interests and support health-promoting policies or be exposed as self-interest groups themselves. Strong advocacy is required to persuade officials that all policies should take health into consideration both to improve lives and economies.

Abstract Background Coronary heart disease (CHD) is the major cause of death in the United States. Coronary artery calcification (CAC) scores are independent predictors of CHD. African Americans (AA) have higher rates of CHD but are less well-studied in genomic studies. We assembled the largest AA data resource currently available with measured CAC to identify associated genetic variants. Methods We analyzed log transformed CAC quantity (ln(CAC + 1)), for association with ~2.5 million single nucleotide polymorphisms (SNPs) and performed an inverse-variance weighted meta-analysis on results for 5,823 AA from 8 studies. Heritability was calculated using family studies. The most significant SNPs among AAs were evaluated in European Ancestry (EA) CAC data; conversely, the significance of published SNPs for CAC/CHD in EA was queried within our AA meta-analysis. Results Heritability of CAC was lower in AA (~30%) than previously reported for EA (~50%). No SNP reached genome wide significance (p < 5E-08). Of 67 SNPs with p < 1E-05 in AA there was no evidence of association in EA CAC data. Four SNPs in regions previously implicated in CAC/CHD (at 9p21 and PHACTR1 ) in EA .