Suchergebnisse

Objectives: It is unclear whether adolescence obesity is associated with limited linear growth. We assessed this association in a nationwide cohort of adolescents. Methods: We conducted a nationwide, population-based, cohort study of 2,785,227 Israeli adolescents (60% males) who were examined before military service in 1967 through 2015; Height and weight were measured along with assessment of medical status at age 17.4±0.4 years. The secular trend of height was plotted for US-CDC age- and sex-adjusted BMI percentiles groups. We accounted for health status at enrolment and computed the expected height based on parental data that was available for 512,978 examinees. Results: Mean height has increased by 3.1 cm among males, but remained unchanged among females over five decades. Among males, gain in height was mostly attained during the first 25 years and has stabled since. Obese males were taller than their normal-weight and underweight counterparts. Underweight girls had a prominent increase in mean height during the first 2 decades exceeding by over 2 cm the mean height of their obese counterparts. There was a gradual decrease in the difference between measured and expected height in males and females regardless of BMI status, with the exception of underweight females who achieved consistently higher stature than expected (≥3 cm). Conclusions: During five decades excessive BMI was not a limiting factor in growth potential compared to normal BMI in both sexes. Underweight females with unimpaired health are the sole group that has yet realized its growth potential even when accounting parental height.

BACKGROUND: Increasing cancer incidence among children alongside improved treatments has resulted in a growing number of pediatric cancer survivors. Despite childhood cancer survivors' exposure to various factors that compromise kidney function, few studies have investigated the association between childhood cancer and future kidney disease. METHODS: To assess the risk of ESKD among childhood cancer survivors, we conducted a nationwide, population-based, retrospective cohort study that encompassed all Israeli adolescents evaluated for mandatory military service from 1967 to 1997. After obtaining detailed histories, we divided the cohort into three groups: participants without a history of tumors, those with a history of a benign tumor (nonmalignant tumor with functional impairment), and those with a history of malignancy (excluding kidney cancer). This database was linked to the Israeli ESKD registry to identify incident ESKD cases. We used Cox proportional hazards models to estimate the hazard ratio (HR) of ESKD. RESULTS: Of the 1,468,600 participants in the cohort, 1,444,345 had no history of tumors, 23,282 had a history of a benign tumor, and 973 had a history of malignancy. During a mean follow-up of 30.3 years, 2416 (0.2%) participants without a history of tumors developed ESKD. Although a history of benign tumors was not associated with an increased ESKD risk, participants with a history of malignancy exhibited a substantially elevated risk for ESKD compared with participants lacking a history of tumors, after controlling for age, sex, enrollment period, and paternal origin (adjusted HR, 3.2; 95% confidence interval, 1.3 to 7.7). CONCLUSIONS: Childhood cancer is associated with an increased risk for ESKD, suggesting the need for tighter and longer nephrological follow-up.