Suchergebnisse

AbstractThe literature on fiscal policies is paying increasing attention to the impact of the composition of public expenditures on long‐term economic growth. Public policy endogenous growth models recommend to change the composition of public expenditures to items considered productive expenditures. In this sense, European institutions are encouraging the rise in the share of productive outlays like public investments, R&D, and active labor market policies, among others. The article analyzes whether these recommendations are followed by European Union countries and whether a convergence to a new pattern of public finances with a higher share of those items considered productive expenditures by European institutions is arising.

A study of Magnetite (Fe3O4) as a suitable matrix for the improved adhesion and proliferation of MC3T3-E1 pre-osteoblast cells in bone regeneration is presented. Biodegradable and magnetic polycaprolactone (PCL)/magnetite (Fe3O4) scaffolds, which were fabricated by Thermally Induced Phase Separation, are likewise analyzed. Various techniques are used to investigate in vitro degradation at 37 °C, over 104 weeks, in a phosphate buffered saline (PBS) solution. Magnetic measurements that were performed at physiological temperature (310 K) indicated that degradation neither modified the nature nor the distribution of the magnetite nanoparticles. The coercive field strength of the porous matrices demonstrated ferromagnetic behavior and the probable presence of particle interactions. The added nanoparticles facilitated the absorption of PBS, with no considerable increase in matrix degradation rates, as shown by the Gel Permeation Chromatography (GPC) results for Mw, Mn, and I. There was no collapse of the scaffold structures that maintained their structural integrity. Their suitability for bone regeneration was also supported by the absence of matrix cytotoxicity in assays, even after additions of up to 20% magnetite. ; This work was supported by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-3-R (AEI/FEDER, UE) and from the Basque Government Industry Department under the ELKARTEK, HAZITEK and PIBA programs. Supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding UID/FIS/04650/2013, project POCI-01-0145-FEDER-028237 and grant SFRH/BD/111478/2015 (S.R.) is acknowledged. ; Technical and human support provided by SGIker (UPV/EHU, MICINN, GV/EJ, ERDF and ESF) is gratefully appreciated. The authors acknowledge funding by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-3-R (AEI/FEDER, UE) and from the Basque Government Industry and Education Department under the ...

Magnetic biomimetic scaffolds of poly(L-lactide) (PLLA) and nanoparticles of magnetite (nFe3O4) are prepared in a wide ratio of compositions by lyophilization for bone regeneration. The magnetic properties, cytotoxicity, and the in vitro degradation of these porous materials are closely studied. The addition of magnetite at 50 °C was found to produce an interaction reaction between the ester groups of the PLLA and the metallic cations of the magnetite, causing the formation of complexes. This fact was confirmed by the analysis of the infrared spectroscopy and the gel permeation chromatography test results. They, respectively, showed a displacement of the absorption bands of the carbonyl group (C=O) of the PLLA and a scission of the polymer chains. The iron from the magnetite acted as a catalyser of the macromolecular scission reaction, which determines the final biomedical applications of the scaffolds—it does so because the reaction shortens the degradation process without appearing to influence its toxicity. None of the samples studied in the tests presented cytotoxicity, even at 70% magnetite concentrations. ; This work was supported by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-3-R (AEI/FEDER, UE) and from the Basque Government Industry Department under the ELKARTEK, HAZITEK and PIBA programs. Supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding UID/FIS/04650/2013, project POCI-01-0145-FEDER-028237 and grant SFRH/BD/111478/2015 (S.R.) is ...

7‐11 November 2010, Tenth International Congress on Drug Therapy in HIV Infection, Glasgow, UK

The unpredictable Anthropocene poses the challenge of imagining a radically different, equitable and sustainable world. Looking 100 years ahead is not easy, and especially as millennials, it appears quite bleak. This paper is the outcome of a visioning exercise carried out in a 2-day workshop, attended by 33 young early career professionals under the auspices of IPBES. The process used Nature Futures Framework in an adapted visioning method from the Seeds of Good Anthropocene project. Four groups envisioned more desirable future worlds; where humanity has organised itself, the economy, politics and technology, to achieve improved nature-human well-being. The four visions had differing conceptualisations of this future. However, there were interesting commonalities in their leverage points for transformative change, including an emphasis on community, fundamentally different economic systems based on sharing and technological solutions to foster sustainability and human-nature connectedness. Debates included questioning the possibility of maintaining local biocultural diversity with increased connectivity globally and the prominence of technology for sustainability outcomes. These visions are the first step towards a wider galvanisation of youth visions for a brighter future, which is often missing in the arena where it can be taken seriously, to trigger more transformative pathways towards meeting global goals. © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

The unpredictable Anthropocene poses the challenge of imagining a radically different, equitable and sustainable world. Looking 100 years ahead is not easy, and especially as millennials, it appears quite bleak. This paper is the outcome of a visioning exercise carried out in a 2-day workshop, attended by 33 young early career professionals under the auspices of IPBES. The process used Nature Futures Framework in an adapted visioning method from the Seeds of Good Anthropocene project. Four groups envisioned more desirable future worlds; where humanity has organised itself, the economy, politics and technology, to achieve improved nature-human well-being. The four visions had differing conceptualisations of this future. However, there were interesting commonalities in their leverage points for transformative change, including an emphasis on community, fundamentally different economic systems based on sharing and technological solutions to foster sustainability and human-nature connectedness. Debates included questioning the possibility of maintaining local biocultural diversity with increased connectivity globally and the prominence of technology for sustainability outcomes. These visions are the first step towards a wider galvanisation of youth visions for a brighter future, which is often missing in the arena where it can be taken seriously, to trigger more transformative pathways towards meeting global goals.

The hosts of long duration gamma-ray bursts (GRBs) are predominantly starburst galaxies at subsolar metallicity. At redshifts z < 1, this implies that most of them are low-mass galaxies similar to the populations of blue compact dwarfs and dwarf irregulars. What triggers the massive star-formation needed for producing a GRB progenitor is still largely unknown, as are the resolved gas properties and kinematics of these galaxies and their formation history. Here we present a sample of six spatially resolved GRB hosts at z < 0.3 observed with 3D spectroscopy at high spectral resolution (R = 8000-13 000) using FLAMES/VLT. We analyzed the resolved gas kinematics of the full sample and the abundances in a subsample with strong enough emission lines. Only two galaxies show a regular disk-like rotation field, another two are dispersion-dominated, and the remaining ones have two narrow emission components associated with different parts of the galaxy but no regular rotation field, which might indicate a recent merger. All galaxies show evidence for broad components underlying the main emission peak with σ of 50-110 km s-1. This broad component is more metal-rich than the narrow components, it is blueshifted in most cases, and it follows a different velocity structure. We find a weak correlation between the star-formation rate and the width of the broad component, its flux compared to the narrow component, and the maximum outflow velocity of the gas, but we do not find any correlation with the star-formation density, metallicity or stellar mass. We hence associate this broad component with a metal-rich outflow from star-forming regions in the host. The GRB is not located in the brightest region of the host, but is always associated with some star-forming region showing a clear wind component. Our study shows the great potential of 3D spectroscopy to study the star-formation processes and history in galaxies hosting extreme transients, the need for high signal-To-noise, and the perils using unresolved or only partially resolved data for these kinds of studies. © ESO 2021. ; CT and AdUP acknowledge support from AYA2017-89384-P, CT and AdUP also from a Ramón y Cajal fellowships RyC-2012-09984 and RyC-2012-09975, LI from a Juan de la Cierva Integración fellowship IJCI-2016-30940. DAK acknowledges support from the Spanish National Research Project RTI2018-098104-J-I00 (GRBPhot). JFAF acknowledges support from the Spanish Ministerio de Ciencia, Innovación y Universidades through the grant PRE2018-086507. SDV acknowledges support from the French National Research Agency (ANR) under contract ANR-16-CE31-0003. LC is supported by YDUN grant DFF 4090-00079. Ground based observations were collected at the VLT under program 092.D-0389(A). ; With funding from the Spanish government through the Severo Ochoa Centre of Excellence accreditation SEV-2017-0709. ; Peer reviewed

PubMed ID: 24186907 ; Background. Interleukin 12Rß1 (IL-12Rß1)-deficient patients are prone to clinical disease caused by mycobacteria, Salmonella, and other intramacrophagic pathogens, probably because of impaired interleukin 12-dependent interferon production. About 25% of patients also display mucocutaneous candidiasis, probably owing to impaired interleukin 23-dependent interleukin 17 immunity. The clinical features and outcome of candidiasis in these patients have not been described before, to our knowledge. We report here the clinical signs of candidiasis in 35 patients with IL-12Rß1 deficiency.Results. Most (n = 71) of the 76 episodes of candidiasis were mucocutaneous. Isolated oropharyngeal candidiasis (OPC) was the most common presentation (59 episodes, 34 patients) and was recurrent or persistent in 26 patients. Esophageal candidiasis (n = 7) was associated with proven OPC in 2 episodes, and cutaneous candidiasis (n = 2) with OPC in 1 patient, whereas isolated vulvovaginal candidiasis (VVC; n = 3) was not. Five episodes of proven invasive candidiasis were documented in 4 patients; 1 of these episodes was community acquired in the absence of any other comorbid condition. The first episode of candidiasis occurred earlier in life (median age±standard deviation, 1.5 ± 7.87 years) than infections with environmental mycobacteria (4.29 ± 11.9 years), Mycobacterium tuberculosis (4 ± 3.12 years), or Salmonella species (4.58 ± 4.17 years) or other rare infections (3 ± 11.67 years). Candidiasis was the first documented infection in 19 of the 35 patients, despite the vaccination of 10 of these 19 patients with live bacille Calmette-Guérin.Conclusions. Patients who are deficient in IL-12Rß1 may have candidiasis, usually mucocutaneous, which is frequently recurrent or persistent. Candidiasis may be the first clinical manifestation in these patients. © The Author 2013. ; University of Chicago Tehran University of Medical Sciences and Health Services Institut National de la Santé et de la Recherche Médicale Rockefeller University Ege Üniversitesi University College London Istanbul Üniversitesi City, University of London, City Comer Children's Hospital, University of Chicago Medicine St. Giles Foundation Université Paris Descartes Ministerio de Economía y Competitividad: PI10/01718, PI06/ 1031 National Center for Advancing Translational Sciences: 8UL1TR000043 Institut National de la Santé et de la Recherche Médicale Fundación Canaria de Investigación y Salud, FUNCIS Ministerio de Ciencia y Tecnología, MICYT: 182817, 69992 European Social Fund, ESF Agence Nationale de la Recherche: GENCMCD 11-BSV3-005-01 Universidad de Las Palmas de Gran Canaria Rockefeller University ANR-10-LABX-62-IBEID National Center for Research Resources European Research Council European Regional Development Fund INREDCAN 05/06 ; 1Pediatric Hematology-Immunology Unit, National Bone Marrow Transplantation Center, Tunis, 2Faculty of Medicine, University of Tunis El Manar, 3Laboratory of Cytoimmunology, Pasteur Institut of Tunis, and 4Department of Cardiology, Ariana Hospital, Tunis, Tunisia; 5Department of Pediatric Immunology and Allergy, Ankara University School of Medicine, 6Immunology Division, Hacettepe University Children's Hospital, 7Department of Pediatric Infectious Diseases, Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Center, and 8Department of Pediatric Immunology, Dr Sami Ulus Children's Health and Diseases Training and Research Center, Ankara, 9Department of Pediatric Infectious Diseases and Clinical Immunology, Istanbul University and Istanbul Medical Faculty, 10Department of Pediatric Immunology, Ege University Faculty of Medicine, Izmir, and 11Department of Pediatric Immunology, Necmettin Erbakan University Meram Medical Faculty, Konya, Turkey; 12Department of Immunology, Gran Canaria Dr Negrín University Hospital, 13Department of Pediatrics and 14Department of Internal Medicine, Complejo Hospitalario Universitario Insular Materno Infantil, and 15Department of Medical and Surgical Sciences, School of Medicine, University of Las Palmas de Gran Canaria, Spain; 16Unit of Biochemistry and 17Laboratory of Microbiology, National Institute of Medical Sciences and Nutrition Salvador Zubirán (INCMNSZ), and 18Department of Pediatric Pulmonology, Laboratory of Pulmonary Physiology, Hospital Infantil de México Federico Gómez, Mexico City; 19Department of Internal Medicine, University Hospital, Maastricht, Netherlands; 20Department of Clinical Biochemistry and Immunology, Addenbrookes Hospital, Cambridge, and 21Department of Medicine, University College London, United Kingdom; 22Pediatric Department, Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel; 23Department of Pediatric Infectious Diseases, Comer Children's Hospital, University of Chicago Medicine, and 24Department of Pediatrics, University of Chicago Medical Center, Illinois; 25St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, New York; 26Department of Pediatrics, UFRJ–Federal University of Rio de Janeiro, Brazil; 27Group of Primary Immunodeficiencies, University of Antioquia, Medellin, Colombia; 28Department of Pediatrics, Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Iran; 29Department of Pediatrics, Hospital Puerto Montt, Chile; 30Department of ?linical Immunology, Center for Pediatric Hematology, Oncology, Immunology, Moscow, Russia; 31Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, 32University Paris Descartes, Imagine Institute, 33Study Center for Primary Immunodeficiencies, Necker Hospital, AP-HP, and 34Pediatric Hematology-Immunology Unit, Necker-Enfants Malades Hospital, AP-HP, Paris, France -- Financial support. This work was supported by Fondo de Investiga-ciones Sanitarias, Ministerio de Economía y Competitividad (grants PI06/ 1031 and PI10/01718), the European Regional Development Fund–European Social Fund (FEDER-FSE), Fundación Canaria de Investigación y Salud (Canarian government; INREDCAN 05/06), Foundation Caja Rural de Cana-rias-Chil y Naranjo (research prize 2004), Universidad de Las Palmas de Gran Canaria (fellowship to E. H. R), INSERM, University Paris Descartes, Rockefeller University, National Center for Research Resources and the National Center for Advancing Sciences of the National Institutes of Health (grant 8UL1TR000043), Laboratoire d'Excellence "Integrative Biology of Emerging Infectious Diseases" (grant ANR-10-LABX-62-IBEID), the European Research Council, Agence Nationale de la Recherche (grant GENCMCD 11-BSV3-005-01), the St Giles Foundation, the Candidoser Association, and Consejo Nacio-nal de Ciencia y Tecnología de Mexico (grants 69992 and 182817). Potential conflicts of interest. All authors: No reported conflicts. --