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Copyright © 2021 The Author(s). We analyse, using a mixture of statistical models and natural language process techniques, what happened in social media from June 2019 onwards to understand the relationships between Cryptocurrencies' prices and social media, focusing on the rise of the Bitcoin and Ethereum prices. In particular, we identify and model the relationship between the cryptocurrencies market price changes, and sentiment and topic discussion occurrences on social media, using Hawkes' Model. We find that some topics occurrences and rise of sentiment in social media precedes certain types of price movements. Specifically, discussions concerning governments, trading, and Ethereum cryptocurrency as an exchange currency appear to negatively affect Bitcoin and Ethereum prices. Those concerning investments, appear to explain price rises, whilst discussions related to new decentralized realities and technological applications explain price falls. Finally, we validate our model using a real case study: the already famous case of "Wallstreetbet and GameStop"1 that took place in January 2021. ; Funding: No funding was received for this work.

We analyse, using a mixture of statistical models and natural language process techniques, what happened in social media from June 2019 onwards to understand the relationships between Cryptocurrencies' prices and social media, focusing on the rise of the Bitcoin and Ethereum prices. In particular, we identify and model the relationship between the cryptocurrencies market price changes, and sentiment and topic discussion occurrences on social media, using Hawkes' Model. We find that some topics occurrences and rise of sentiment in social media precedes certain types of price movements. Specifically, discussions concerning governments, trading, and Ethereum cryptocurrency as an exchange currency appear to negatively affect Bitcoin and Ethereum prices. Those concerning investments, appear to explain price rises, whilst discussions related to new decentralized realities and technological applications explain price falls. Finally, we validate our model using a real case study: the already famous case of "Wallstreetbet and GameStop"1 that took place in January 2021.

The presence of preferred orientations in single particle analysis (SPA) by cryo-Electron Microscopy (cryoEM) is currently one of the hurdles preventing many structural analyses from yielding high-resolution structures. Although the existence of preferred orientations is mostly related to the grid preparation, in this technical note, we show that some image processing algorithms used for angular assignment and three-dimensional (3D) reconstruction are more robust than others to these detrimental conditions. We exemplify this argument with three different data sets in which the presence of preferred orientations hindered achieving a 3D reconstruction without artifacts or, even worse, a 3D reconstruction could never be achieved ; We acknowledge support from "la Caixa" Foundation (Fellowship LCF/BQ/DI18/11660021. This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 713673. We also thank the financial support from the Spanish Ministry of Economy and Competitiveness through Grants BIO2016-76400-R(AEI/FEDER, UE) and SEV 2017-0712, the "Comunidad Autónoma de Madrid" through Grant: S2017/BMD-3817, Instituto de Salud Carlos III, PT17/ 0009/0010 (ISCIII-SGEFI/ERDF), European Union (EU) and Horizon 2020 through grants: CORBEL (INFRADEV-1-2014-1, Proposal: 654248), INSTRUCT-ULTRA (INFRADEV-03-2016-2017, Proposal: 731005), EOSC Life (INFRAEOSC-04-2018, Proposal: 824087), High- ResCells (ERC-2018-SyG, Proposal: 810057), IMpaCT (WIDESPREAD-03-2018 – Proposal: 857203), EOSC-Synergy (EINFRA-EOSC-5, Proposal: 857647), and iNEXT-Discovery (Proposal: 871037). The authors acknowledge the support and the use of resources of Instruct, a Landmark ESFRI project