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Over the last decade the continuous improvements in sensor technologies, connected with recent hardware reconfigurable devices evolution, enable engineers to merge sensors and reconfigurable devices to develop new applications or to improve the existing ones. The miniaturization and integration of multiple sensors in one chip and the increase of precision, stability and power efficiency allow sensors to play an even more important role in medical technology with the main objective of building more accurate and smaller devices that help medical personal to monitor human biomedical parameters. This paper describes a secured wireless system design and implementation. The proposed system consists in one or more wearable sensor nodes that measure human biomedical parameters and then sends the collected data to a base station in order to be analyzed by qualified personal. This system can be used to monitor patient state-of-health or to supervise military personal in training or even in battles, because the new system uses secured transmission. The typical monitored parameters are body temperature, blood oxygen level, heart rate, respiratory rate, movement and position of the subject, but it can be extended and more other different sensors such as cameras or microphones can be added. Reconfigurable devices are used to process data in both sensor node and base station in an innovative environment. Keywords: biomedical parameters, reconfigurable devices, sensor nodes, wireless.

This research focuses on the presence of stereotypes regarding age and gender, using as case study the book Cities for people, by Jan Gehl. Recognized worldwide as one of the most important supporters for the rapprochement of the public urban space towards its citizens, Jan Gehl dedicated most of his career to the importance of the human factor in the planning of cities. This study represents a content analysis of the ways in which the characters from the Cities for people book are being presented according to gender and age. The research represents a quantitative analysis of all the images in the book, comprising individuals or groups of people (collective characters) involved in different types of actions. The results of the study highlight an a relatively equal presence of both genders (48.8% feminine characters and 51.2% masculine characters). Most of the images present individual characters, which gives us the opportunity to clearly see their general image, socio-demographic characteristics (relative age and gender) or carried actions. However, there is a significant percentage of nearly 21% of the images in which the characters are presented as part of a crowd, as collective characters, which causes an increased degree of un-individualization. Even in these cases, non the less, there can be frequently observed a relatively homogeneous mass of people, most of them male adults. The biggest discrepancy highlighted by the study of the images of this book is with regard to the distribution of the main age categories (children, adolescents, adults and seniors). When it comes to these categories, Cities for people gives a greater attention to the adults, a category of people which is present in nearly 50% of the images. The other 50% is divided between children, adolescents and seniors, the most disadvantaged of them being, surprisingly, the children's category (present in only 12.1% of the images).

The digit ratio (2D:4D) has been associated with prenatal hormonal influences and various traits and pathologies. This article explores the relationship between 2D:4D and a series of common polymorphisms and Torque Teno Viruses. In this study, 120 healthy participants were included. The IGF2 Apa I, ACE I/D, INS -23 Hph I, VDR Fok I, VDR Apa I, VDR Taq I, AT1R A1166C polymorphism were genotyped by PCR-RFLP technique, and the IL-6 -174 G/C polymorphism by tetra-primer ARMS-PCR. The presence of TTV was identified by a hemi-nested PCR technique. Haplotype analyses were performed using the SHEsis software. The average 2D:4D values were similar for men and women. Overweight men presented higher 2D4D ratios than normal-weight women (p 0.05). Lower 2D:4D values were recorded in women with pregnancy loss or one child or none (p 0.001). Men with lower 2D4D ratios reported a higher number of children (p 0.001). The IGF2 GG and ACE DD were associated with a higher digit ratio in all subjects and in the women's subset. A significant association was found in men between 2D:4D and the INS-23 Hph I – IGF2 Apa I T-G haplotype (p 0.01). The data obtained in this study indicate a sexual dimorphism for the digit ratio. The associations between 2D:4D and the genetic polymorphisms studied could be influenced by gender.

"The cytogenetic aberrations induced by doxorubicin (DOX) may be influenced by diet. Investigation regarding effects of low doses of DOX on chromosomal aberrations frequency in mice bone marrow. The study explored a possible relationship between diet, follow-up period, and cytostatic doses. Four mice groups received normal or high-fat (pork) diet. At the beginning of the 8th day mice from each group received a single intraperitoneal injection with DOX (dose range: 1.7-7.7 mg/kg b.w.) or isotonic saline solution (0.02 mL/g control mice). In the 10th (groups I, II) and 14th (groups III, IV) days from the beginning of the experiment, the mice were euthanized and chromosome aberrations were tested in bone marrow cells. The body weight of all mice who received DOX decreases, especially at higher doses. In the first three days post-injection, weight loss percentage was significantly influenced by DOX doses and/or type of diet (p<0.003). The interaction between the type of diet and DOX doses was not statistically significant in the follow-up period (p interactions >0.05). DOX doses were able to increase the frequency of chromosomal aberrations. DOX acts as a potent inductor of cytogenetic aberrations in bone marrow cells, regardless of the type of diet."

"The purpose of this article is to investigate the role of emotional regulation (ER) as a process underlying a variety of symptoms associated with Lynch syndrome (depression, anxiety, fear of cancer recurrence (FCR), insomnia, fatigue, pain, and subjective cognitive difficulties in patients with Lynch syndrome. Firstly, we provided an overview of the main psychopathological symptoms found in cancer patients and their impact, and then an overview of emotional regulation strategies and discussed the main impact ER strategies have on cancer patients, especially emotional suppression and experiential avoidance, as found in evidence-based studies. Recent research has shown that two ER strategies generally considered maladaptive, emotional suppression and experiential avoidance were significantly associated with higher levels of anxiety, depression, FCR, fatigue, and cognitive difficulties. We propose that experiential avoidance and emotional suppression may be common transdiagnostic mechanisms for a common set of psychological symptoms in Lynch syndrome patients, a hypothesis to be tested in a future study."

Background: Head and neck cancers, and particularly, oral cancers have a complex pathogenesis that includes genetic
mutations and epigenetic alterations which interfere with cellular signaling and can trigger tumor development. The purpose of
this study was to reveal whether low-frequency hotspot mutations may be detected in a study lot with histopathological evidence
of squamous cell carcinoma (SCC) of the oral mucosa and skin of the head and neck. Methods: Tumor biopsies from treatment
naïve patients were tested for BRAF V600, NRAS G12/G13, NRAS Q61, KRAS Q61 mutations, and EGFR exon 19 deletions (Ex19Del)
using droplet digital PCR (ddPCR). The tumors were also analyzed for EGFR T790M mutations by RT-PCR, using a CE-IVD validated
kit, with a limit of detection of 0.05%. Results: None of the examined cases exhibited NRAS G12/G13, NRAS Q61, KRAS Q61, BRAF
V600, or EGFR T790M mutations, indicating that these alterations are rare events in SCC pathogenesis. Interestingly, among the
12 specimens tested by ddPCR for EGFR Ex19Del, an HPV-negative cSCC tumor occurring in the parotid region tested positive for
this drug-sensitizing mutation, offering unexplored therapeutic perspectives to the patient from whom it was collected.
Conclusions: Our study highlights the important clinical implications of detecting low-frequency hotspot mutations in tumor
biopsies by ddPCR. We believe that the ddPCR-assisted analysis of these mutations in larger SCC cohorts may provide us with
mechanistic insights regarding their role in SCC pathogenesis and guide the development of novel therapeutic strategies for this
problematic disease.

Metformin was a revelation in the treatment of patients with type 2 diabetes, being widely used, with remarkable outcomes. Lately, research has greatly expanded the indications of metformin treatment, which can be used not only in diabetes but also in many other conditions. Although still debatable, several studies have shown the beneficial effects of metformin treatment in patients with psoriasis. This article is a review of the latest data of scientific literature about the effects of metformin administration in patients with diabetes and psoriasis, but also in nondiabetic patients with psoriasis.

Abstract: Stroke has a significant prevalence in Romania. The predisposition for this multifactorial disease is partially known. The aim of this study is to investigate the predisposition for stroke in Romanian population. Material and methods. We selected cases with recent ischemic stroke (n=100) and healthy control subjects (n=100). The AGTR1 A1166C (rs5186) polymorphism was genotyped by restriction of amplicons with Dde I endonuclease. Results. Active cigarette smoking (O.R. =6.92, p=0.0001) or presence of the AT1R C variant (O.R. =6.69, p=0.0006) in overweight or obese women significantly increase the risk for ischemic stroke. The diagnosis of stroke (71.5 vs 68 years old) or T2DM (63.39 vs 60.77 years old) was recorded at an older age in women compared to men (p<0.05). Obesity considered independent (O.R. =4.22, p<0.05) or in association with T2DM (O.R. = 10.16, p=0.0002) confers the highest risk of stroke when compared to women. Conclusions. Obesity in association with T2DM confers the highest risk of stroke for men when compared to women. Active cigarette smoking or AT1R C variant significantly increase the risk for stroke in women with a high BMI compared with controls. Keywords: stroke, AT1R, BMI, cigarette smoking

"Assessment of Geography Teaching-Learning Process Through Game, in Pre-University Education. A general problem recognized in the educational process is the need to identify the manner in which the teacher, as the factor with the greatest influence on learning, increases the students' school performance. The creation of a tool in the form of an interactive website, using types of languages to improve an easy understanding of learning, the formation of specific competences and the students' enhanced motivation for study are the objectives of this study. This study evaluates the teaching-learning system through its own created game, using certain types of computer languages: HTML, CSS and JavaScript, from the perspective of measuring the impact of the effect on tests in the formative assessment sequence of students, compared to other teaching-learning methods. The experiment, observations, performance analysis and qualitative Google Forms questionnaires, suggested a high degree of student engagement and how game technology can facilitate teaching. As the results have shown that there is a strong difference between experimental and control groups, it indicates that educational play has had a positive impact on learning and increasing students' interest, confirming the advantages of learning through play. The teaching-learning model can be extended to use at national and international level. Keywords: teaching-learning through game; Geography; Google Forms; HTML computer language; CSS and JavaScript. "

The long-distance post-SARS-CoV2 infection effects were partially known. The study aims to follow the evolution of the patients with acute post-COVID 19 clinical symptoms presented in the Emergency Department. Methods: We analyzed 262 presentations more than 14 days after the initial COVID-19 diagnosis and with at least one acute COVID-19-related symptom. This study included presented between 01.01 and 31.05.2021 in the Emergency Department of Bucharsti- Emergency University Hospital. Data were obtained in real-time, at the presentation, from the patients' medical charts, and afterward from SUUB's database. Results. Out of the total of 262 presentations, 40.84% required patient hospitalization. The highest number of presentations with (18.70%) or without (22.90%) hospitalization was recorded in the first month after the COVID-19 diagnosis. Patients with less than 30 days between presentations had significantly fewer hospitalization days, compared to those with more than 30 days between presentations (8.3 vs 14.14 days, p=0.009). We found a high amount of hospitalization days (1093 days), with 29.88% deaths. Conclusions: COVID-19 complications require prolonged hospitalization, with implications on the patients' quality of life, the overcrowding of intensive care facilities, high-cost treatment, and unfavorable evolution for a great number of patients