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This study evaluated the effectiveness of a 12-week psychoeducational group therapy program in improving mood and glycemic control in adults with diabetes and visual impairments. The participants made statistically significant gains in glycemic control, and there was a significant positive relationship between control and improvement in depression, but greater knowledge of diabetes self-care did not correlate with improved glycemic control.

Laboratory groups attempted to reach consensus on a simulated business problem. Members of 4-person groups received information on whether three proposed systems met each of IO desired criteria. Cast as a hidden profile problem, the information was distributed unevenly within the group. Groups communicated using one ofthreeformats:face-to-face, teleconference, or electronic chat. As predicted, cognitive workload was significantly higher andfewer correct decisions were obtained in the electronic chat condition versus the other twoformats. The electronic chat medium limited participants' ability to coordinate and verify information. Electronic chat should be combined with collaboration technology or groupware that facilitates information storage, organization, and processing.

Neuropathological subtypes of hippocampal sclerosis (HS) in temporal lobe epilepsy (The2013 International League Against Epilepsy classification) are based on the qualitativeassessment of patterns of neuronal loss with NeuN. In practice, some cases appear indeterminate between type 1 (CA1 and CA4 loss) and type 2 HS (CA1 loss) and we predicted that MAP2 would enable a more stringent classification. HS subtypes, as well asthe accompanying alteration of axonal networks, regenerative capacity and neurodegeneration have been previously correlated with outcome and memory deficits and may provide prognostic clinical information. We selected 92 cases: 52 type 1 HS, 15 type 2 HS, 18 indeterminate-HS and 7 no-HS. Quantitative analysis was carried out on NeuN and MAP2 stained sections and a labeling index (LI) calculated for six hippocampal subfields. We also evaluated hippocampal regenerative activity (MCM2, nestin, olig2, calbindin), degeneration (AT8/phosphorylated tau) and mossy-fiber pathway re-organization (ZnT3). Pathology measures were correlated with clinical epilepsy history, memory and naming test scores and postoperative outcomes, at 1 year following surgery. MAP2 LI in indeterminate-HS was statistically similar to type 2 HS but this clustering was not shown with NeuN. Moderate verbal and visual memory deficits were noted in all HS types, including 54% and 69% of type 2 HS. Memory deficits correlated with several pathology factors including lower NeuN or MAP2 LI in CA4, CA1, dentate gyrus (DG) and subiculum and poor preservation of the mossy fiber pathway. Decline in memory at 1 year associated with AT8 labeling in the subiculum and DG but not HS type. We conclude that MAP2 is a helpful addition in the classification of HS in some cases. Classification of HS subtype, however, did not significantly correlate with outcome or pre- or postoperative memory dysfunction, which was associated with multiple pathology factors including hippocampal axonal pathways, regenerative capacity and degenerative changes. ; European Union ; CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) ; Medical Research Council ; Department of Health's NIHR Biomedical Research Centres funding scheme ; Epilepsy Society ; UCL Inst Neurol, Dept Clin & Expt Epilepsy, London WCN 1BG, England ; Univ Fed Sao Paulo, Dept Neurol & Neurosurg, UNIFESP, Sao Paulo, Brazil ; Natl Hosp Neurol & Neurosurg, Dept Neuropathol, Queen Sq, London WCN 1BG, England ; Natl Hosp Neurol & Neurosurg, Dept Neurol, Queen Sq, London WCN 1BG, England ; Univ Lausanne, CHUV, Dept Neurosci Clin, Serv Neurol, Lausanne, Switzerland ; Natl Hosp Neurol & Neurosurg, Dept Neurosurg, Queen Sq, London WCN 1BG, England ; Natl Hosp Neurol & Neurosurg, Dept Neuropsychol, Queen Sq, London WCN 1BG, England ; Epilepsy Soc Res Ctr, Epilepsy Soc, Gerrards Cross SL9 0RJ, Bucks, England ; Univ Fed Sao Paulo, Dept Neurol & Neurosurg, UNIFESP, Sao Paulo, Brazil ; EU: 602102 ; MRC: MR/JO127OX/1 ; Web of Science