Suchergebnisse

OBJECTIVE: To understand the relationships between traumatic brain injury (TBI), blood biomarkers, and symptoms of posttraumatic stress disorder (PTSD), depression, and postconcussive syndrome symptoms (PCS). DESIGN: Cross-sectional cohort study using multivariate analyses. PARTICIPANTS: One-hundred-and-nine military personnel and Veterans, both with and without a history of TBI. MAIN MEASURES: PTSD Checklist-Civilian Version (PCL); Neurobehavioral Symptom Inventory (NSI); Ohio State University TBI Identification Method; Patient Health Questionnaire-9 (PHQ-9); Simoa™-measured concentrations of tau, Amyloid-beta (Aβ40, −42, and NFL. RESULTS: Controlling for age, sex, time since last injury (TSLI) and anti-anxiety/depression medication use, NFL was trending towards being significantly elevated in participants who had sustained 3 or more TBIs compared to those who had sustained 1–2. Within the TBI group, partial correlations which controlled for age, sex, TSLI and anti-anxiety/depression medication use, showed that tau concentrations were significantly correlated with greater symptom severity, as measured with the NSI, PCL and PHQ-9. CONCLUSIONS: Elevations in tau are associated with symptom severity after TBI, while NFL levels are elevated in those with a history of repetitive TBI, in military personnel and Veterans. This study shows the utility of measuring biomarkers chronically post-injury. Furthermore, there is a critical need for studies of biomarkers longitudinally following TBI.