Suchergebnisse

Corrigendum to "Biological impact of metal nanomaterials in relation to their physicochemical characteristics" [Toxicol in Vitro. 2019 Jan 29;56:172-183]. [Toxicol In Vitro. 2019]. Toxicol In Vitro. 2019 Feb 16. pii: S0887-2333(19)30110-9. doi:10.1016/j.tiv.2019.02.001. [Epub ahead of print]. Disponível em: https://www.sciencedirect.com/science/article/pii/S0887233319301109?via%3Dihub ; Several metal and metal oxide nanomaterials (NMs), e.g., cerium dioxide NMs(CeO2), barium sulphate NMs(BaSO4) and titanium dioxide NMs(TiO2), display advantageous properties over the bulk materials and have a broad range of innovative applications in food, industry and consumer products. Whether these materials are hazardous and impact on human health or the environment remains an issue that needs to be addressed by reliable studies focused on nano-bio interactions. To contribute to the comprehensive investigation of the toxicological effects of metal NMs, we have assessed the cytotoxic and genotoxic effects of benchmark NMs in human respiratory cells, concomitantly with the analysis of their secondary properties in the cellular moiety. This study shows no effects of BaSO4, while some, but not all, of the other metal-related NMs analyzed have adverse effects. Human respiratory cells were prone to CeO2 cytotoxicity and to DNA damage induction following exposure to anatase TiO2 (NM-100, NM-101 and NM-102), but not rutile TiO2. No clastogenic/aneugenic effects were ascribed to any of the tested NMs. Using correlation analysis, this work also suggests that among these TiO2, the size in the cellular moiety may be the most relevant secondary feature that determines their biological consequences. ; This work was financed by national funds through the FCT - Foundation for Science and Technology, I.P., under the project PTDC/ SAU-PUB/29481/2017. Research co-funded by European Union Seventh Framework Programme (FP7/2007e2013) under the project NANoREG (A common European approach to the regulatory testing of NMs), grant agreement 310584 and by UID/BIM/00009/2013 (Centre for Toxicogenomics and Human Health – ToxOmics, Foundation for Science and Technology). ; info:eu-repo/semantics/publishedVersion