This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017 ; Support NIH R01EY021834, R01EY014225 and P30EY14801, the Australian Federal Government CRC Scheme through the Vision Cooperative Research Centre, Florida Lions Eye Bank, Research to Prevent Blindness, Drs KR Olsen and ME Hildebrandt, Drs Raksha Urs and Aaron Furtado, Henri and Flore Lesieur Foundation (JMP), Hyderabad Eye Research Foundation, European Research Council ERC-AdG 294099 and CSIC iCoop Program ; Peer reviewed
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018 ; Support NEI Grants: R01EY021834, F31EY021444 (Maceo), P30EY14801 (Center Grant); the Florida Lions Eye Bank; Research to Prevent Blindness; Australian Federal Government CRC Program (Vision CRC); Drs. KR Olsen and ME Hildebrandt, Drs. Raksha Urs and Aaron Furtado, the Henri and Flore Lesieur Foundation (JMP); Hyderabad Eye Research Foundation, European Research Council ERC-AdG 294099, FIS2014-56643-R and CSIC iCoop Program. ; Peer reviewed
Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. in this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian, and Korean patients with CM-SJS/TEN with SOC, and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06. We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population, and that HLA-A*02:06 might be weakly associated in the Korean-but not the Indian and Brazilian population. ; Ministry of Education, Culture, Sports, Science and Technology of the Japanese government ; Japanese Ministry of Health, Labour and Welfare ; Kyoto Foundation for the Promotion of Medical Science ; Intramural Research Fund of Kyoto Prefectural University of Medicine ; Promotion Project of Knowledge-Based Industrial Clustering of Okinawa Prefecture ; Kyoto Prefectural Univ Med, Dept Ophthalmol, Kyoto, Japan ; Doshisha Univ, Fac Life & Med Sci, Res Ctr Inflammat & Regenerat, Kyoto 602, Japan ; LV Prasad Eye Inst, Prof Brien Holden Eye Res Ctr, Hyderabad, Andhra Pradesh, India ; Universidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil ; Seoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea ; Chonnam Natl Univ, Dept Ophthalmol, Kwangju, South Korea ; Yonsei Univ, Coll Med, Severance Hosp, Inst Vis Res,Dept Ophthalmol, Seoul, South Korea ; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Ophthalmol & Visual Sci, Seoul, South Korea ; LV Prasad Eye Inst, Cornea & Anterior Segment Serv, Hyderabad, Andhra Pradesh, India ; Univ Tokyo, Grad Sch Med, Dept Human Genet, Tokyo, Japan ; Universidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil ; Web of Science
