Suchergebnisse

Comme Dans Tant D'autres Régions D'Europe la Sicile comptait, vers le milieu du XVIIIe siècle, une grande quantité de paysans sans travail, réduits à une condition désespérée, mendiant à travers l'île au rythme des saisons et des hasards des récoltes, à l'occasion s'adonnant au vol, au brigandage, ou gagnant la capitale — Palerme — à la recherche, pour vivre, de quelques libéralités du gouvernement ou de riches particuliersA Palerme, la disette de blé de 1772, qu'accompagna une grave pénurie de légumes et autres produits alimentaires, accentua encore l'habituel spectacle. Durant ces mois, écrit Bianchini, « les pauvres accouraient de partout à Palerme et étaient entretenus aux frais de la commune ». Les voyageurs, en visite dans l'île, ne pouvaient pas n'être pas frappés par « cette troupe de populace qui, après avoir épuisé les campagnes, bouillonnait dans la ville ».

The aim of the article is to compare two emergency migration legislation adopted in Italy and Portugal. The article attempts to prove the link between integration and law, analyzing the different approaches of Italy and Portugal to the policy problem during the COVID-19 pandemic. As two of the Southern EU Member States with different views on immigration policies, Italy and Portugal represent an interesting case study to investigate. The article benefits from an interdisciplinary approach, addressing the issue, combining both the legal and political literature. Ultimately, the article tries to assess if the current measures are in line with the regularization policies that have been adopted in the past decade. The main finding is that both states tend to pass emergency legislation favoring migrants and granting them equal access to healthcare during the COVID-19 pandemic, assessing the link between law and integration. Further empirical research is desirable.

AL amyloidosis is characterized by widespread deposition of immunoglobulin light chains (LCs) as amyloid fibrils. Cardiac involvement is frequent and leads to life-threatening cardiomyopathy. Besides the tissue alteration caused by fibrils, clinical and experimental evidence indicates that cardiac damage is also caused by proteotoxicity of prefibrillar amyloidogenic species. As in other amyloidoses, the damage mechanisms at cellular level are complex and largely undefined. We have characterized the molecular changes in primary human cardiac fibroblasts (hCFs) exposed in vitro to soluble amyloidogenic cardiotoxic LCs from AL cardiomyopathy patients. To evaluate proteome alterations caused by a representative cardiotropic LC, we combined gel-based with label-free shotgun analysis and performed bioinformatics and data validation studies. To assess the generalizability of our results we explored the effects of multiple LCs on hCF viability and on levels of a subset of cellular proteins. Our results indicate that exposure of hCFs to cardiotropic LCs translates into proteome remodeling, associated with apoptosis activation and oxidative stress. The proteome alterations affect proteins involved in cytoskeletal organization, protein synthesis and quality control, mitochondrial activity and metabolism, signal transduction and molecular trafficking. These results support and expand the concept that soluble amyloidogenic cardiotropic LCs exert toxic effects on cardiac cells. ; This work was supported by the PRIME-XS project, grant agreement number 262067, funded by the European Union 7th Framework Programme; the Italian Ministry of Health (GR-2010-2317596); Associazione Italiana per la Ricerca sul Cancro special program "5 per mille" (number 9965); Fondazione Cariplo (2013-0964, 2015-0591 and 2016-0489); the Italian Ministry of Health, research target project "Cardiac amyloidosis: molecular mechanism and innovative therapies for a challenging aging" (RF-2013-02355259); POR Campania FSE 2007-2013, Project DIAINTECH; and by Grant PON03PE_00060_2 and PON03PE_00060_7 (Campania - Bioscience) from the Italian Ministry of University and Research. The CRG/UPF Proteomics Unit is part of the "Plataforma de Recursos Biomoleculares y Bioinformáticos (ProteoRed)" supported by grant PT13/0001 of ISCIII and Spanish Ministry of Economy and Competitiveness. We acknowledge support of the Spanish Ministry of Economy and Competitiveness, "Centro de Excelencia Severo Ochoa 2013-2017", SEV-2012-0208, and from "Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement de la Generalitat de Catalunya" (2014SGR678).