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Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Preface -- Editors -- List of Contributors -- Chapter 1 Human-Animal Interactions -- Introduction -- Defining Human-Animal Interactions -- Impacts of Human-Animal Interactions -- Ecological Framework -- Animals -- Animal Welfare Theoretical Framework -- Harms for Animals -- Benefits for Animals -- Humans -- Human Theoretical Frameworks -- Harms for Humans -- Benefits for Humans -- Recommendations -- Principles -- Changing Human Behavior to Improve Animal Welfare -- Limitations and Future Work -- Conclusion -- References -- Chapter 2 A Culture of Care -- Background: Why a "Culture of Care?" -- What Is the Culture of Care? -- Implementing a Culture of Care -- The People Perspective -- The 3Rs Perspective -- The Good Science Perspective -- Methods and Tools to Shape a Culture -- The Role of Local Ethics or Animal Care and Use Committees -- Culture of Challenge -- Assessing the Culture of Care -- What Matters -- Surrogate Markers -- Building a Survey -- Assessing the Impact of the Culture of Care -- Promoting the Culture of Care -- National Meetings Arranged by Authorities -- Scientific Congresses and Meetings -- Organizations and Networks -- Other Opportunities to Promote the Culture of Care -- Conclusion -- References -- Chapter 3 Animal Emotions and Moods: Why They Matter -- Introduction -- Panksepp's Seven Core Emotions -- CARE -- GRIEF -- PLAY -- LUST -- SEEKING -- FEAR -- RAGE -- Summary of the Core Emotional Systems -- Core Affect Space -- Moods -- Welfare and Positioning in Core Affect Space -- Combining the Two Models of Emotion -- Conclusion -- References -- Chapter 4 Abnormal Behavior -- Abnormality -- Why We Should Care about Abnormal Behaviors -- Maladaptive or Malfunctional? -- Species Differences -- Abnormal Repetitive Behavior Prevention.

This book explores central aspects of genetic modification of animals for scientific purposes in the context technological possibilities, regulatory issues in different regions, animal welfare implications and wider ethical issues exemplified through current theories and frameworks. This discussion of lab animals produced through modern biotechnologies becomes increasingly pressing as CRISPR-Cas9 technology advances rapidly, challenging legal and ethical frameworks all over the world. Such animals are now affordable and readily available to almost every branch of scientific research. This not only raises enormous potential for creating tailored' models for human diseases but also rubs up against the traditional guiding principles (the 3Rs) for the humane use of animals for scientific experiments and raises wider ethical issues around death, integrity and naturalness. In this book, expert authors from diverse backgrounds in laboratory animal care, animal research, technology and animal rights explore a range of topics, from the science behind biotech research animals and the regulation of their use, to utilitarian, animal rights, virtue ethics and ethics of care, and critical animalstudiers' perspectives on the use of these technologies. Whatever your background or role in animal research, this book will challenge and stimulate deeper consideration of the benefits, disadvantages and ethical consequences of the use of biotechnology in the animal laboratory.