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Trafficking in women and girls is a serious human rights violation that has deleterious consequences for many individuals and communities worldwide. Although numerous anti‐trafficking programs and policies have been implemented, the majority have adopted a law enforcement approach that has yielded little progress. In this article, we draw on the public health lens to discuss a set of principles that aim to guide anti‐trafficking interventions toward a more comprehensive framework of action to address trafficking in women and girls. Given the complex causes and consequences associated with the issue, anti‐trafficking interventions must address a range of factors, from the social determinants enabling the gender discriminatory norms and conditions that facilitate the problem, to the diverse health needs of individuals throughout the trafficking process. Additionally, anti‐trafficking policies and programs should be implemented with the best available evidence and in partnership with relevant stakeholders, including the survivors themselves, while incorporating the unique opportunities and challenges of the different trafficking contexts.

Low- and middle-income countries (LMICs) bear the brunt of communicable and non-communicable diseases and experience higher mortality and poor health outcomes compared to resource-rich countries. Chronic resource deficits in LMICs impede their ability to successfully address vexing health issues. Implementation science provides researchers with an approach to develop specific interventions that can generate and/or maximize resources to facilitate the implementation of other public health interventions, in resource-constrained LMIC settings. Resources generated from these interventions could be in the form of increased health workers' skills, task shifting to free up higher-skilled health workers, increasing laboratory capacity, and using supply chain innovations to make medications available. Pivotal to the success of such interventions is ensuring feasibility in the LMIC context. We selected and appraised three case studies of evidence-based resource-generating health interventions based in LMICs (Zambia, Zimbabwe, and Madagascar), which generated or maximized resources to facilitate ongoing health services. We used a determinant implementation framework—Consolidated Framework for Implementation Research (CFIR) to identify and map contextual factors that are reported to influence implementation feasibility in an LMIC setting. Contextual factors influencing the feasibility of these interventions included leadership engagement, local capacity building and readiness for research and implementing evidence-based practices (EBPs), infrastructural support for multilevel scale-up, and cultural and contextual adaptations. These factors highlight the importance of utilizing implementation science frameworks to evaluate, guide, and execute feasible public health interventions and projects in resource-limited settings. Within LMICs, we recommend EBPs incorporate feasible resource-generating components in health interventions to ensure improved and sustained optimal health outcomes.