Suchergebnisse

Based upon twelve months of anthropological fieldwork in Cabo Pulmo, Baja California Sur, Mexico, this article uses political ecology and theoretical work on ideology to examine how local residents use the concept of sustainability to advocate for alternative visions of development. Conceptually, the idea of sustainability has a long, often conflicted history. As political ecologists have pointed out, sustainability can be everything from a tool of dominance and pacification to a strident defense of environment, place, and local rights. Between 2010 and 2012, the residents of Cabo Pulmo waged a campaign against a large-scale tourism development that was perceived as a threat to local livelihoods and environmental health. They deployed the concept of sustainability during this campaign, and afterwards, as a way to build local solidarity in the face of increasing development pressures. Sustainability works as a temporary ideological tool that transcends internal disputes during intense conflicts over the meaning of development.Keywords: Sustainability, ideology, development, Baja California Sur, Mexico

Based upon twelve months of anthropological fieldwork in Cabo Pulmo, Baja California Sur, Mexico, this article uses political ecology and theoretical work on ideology to examine how local residents use the concept of sustainability to advocate for alternative visions of development. Conceptually, the idea of sustainability has a long, often conflicted history. As political ecologists have pointed out, sustainability can be everything from a tool of dominance and pacification to a strident defense of environment, place, and local rights. Between 2010 and 2012, the residents of Cabo Pulmo waged a campaign against a large-scale tourism development that was perceived as a threat to local livelihoods and environmental health. They deployed the concept of sustainability during this campaign, and afterwards, as a way to build local solidarity in the face of increasing development pressures. Sustainability works as a temporary ideological tool that transcends internal disputes during intense conflicts over the meaning of development.Keywords: Sustainability, ideology, development, Baja California Sur, Mexico

In a little more than a decade, Germany's role in international affairs—particularly from a military perspective—has radically changed. WhereasGerman participation during the Persian Gulf War of 1991 wasbasically limited to providing financial support to the internationalcoalition led by the United States, by the end of 2001, German soldierswere operating under combat conditions in the United Nations peacekeepingmission to Afghanistan. During (and even before) this transition,little attention has been devoted to the German Bundestag'sconstitutional role as overseer of executive foreign affairs activities.

Purpose
This paper aims to reflect on approaches through which open, distance and e-learning (ODeL) students can use their local environments for assessments and explores how this shapes their conceptualisations of "university" and "campus". Key issues and lessons learnt are covered, thus providing pointers for implementation of the type of assessment approaches that are presented.


Design/methodology/approach
Using three undergraduate sustainability-related modules in the Department of Geography, University of South Africa (Unisa), the lecturers' reflections on the real-world sustainability learning experiences of students in these modules (2015-2018) have been cross-correlated and compared to present an integrated picture of emerging best practice.


Findings
The use of real-world, place-based applications, which form a central theme in the assessment strategy for all three modules, allows students to deal hands-on with sustainability issues, establishes a connection between ODeL students and the university and presents an opportunity to engage these students in real-world sustainability learning despite not being on campus.


Research limitations/implications
The case study format and qualitative, reflective methodology present limitations, while specifically focusing on ODeL and the final phase of undergraduate studies. Despite these limitations, the lessons learnt can be of value to universities currently transferring to online offerings, with possible impacts for sustainability learning.


Originality/value
This paper addresses misconceptions on the role of ODeL in transforming to sustainability. The criticism that ODeL is suitable for primarily theoretical training is countered by evidence that appropriately structured assessments requiring ODeL students to engage with real-world issues in their local environments, can provide valuable sustainability learning experiences.

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Due to compromised homologous recombination (HR) repair, BRCA1- and BRCA2-mutated tumours accumulate DNA damage and genomic rearrangements conducive of tumour progression. To identify drugs that target specifically BRCA2-deficient cells, we screened a chemical library containing compounds in clinical use. The top hit was chlorambucil, a bifunctional alkylating agent used for the treatment of chronic lymphocytic leukaemia (CLL). We establish that chlorambucil is specifically toxic to BRCA1/2-deficient cells, including olaparib-resistant and cisplatin-resistant ones, suggesting the potential clinical use of chlorambucil against disease which has become resistant to these drugs. Additionally, chlorambucil eradicates BRCA2-deficient xenografts and inhibits growth of olaparib-resistant patient-derived tumour xenografts (PDTXs). We demonstrate that chlorambucil inflicts replication-associated DNA double-strand breaks (DSBs), similarly to cisplatin, and we identify ATR, FANCD2 and the SNM1A nuclease as determinants of sensitivity to both drugs. Importantly, chlorambucil is substantially less toxic to normal cells and tissues in vitro and in vivo relative to cisplatin. Because chlorambucil and cisplatin are equally effective inhibitors of BRCA2-compromised tumours, our results indicate that chlorambucil has a higher therapeutic index than cisplatin in targeting BRCA-deficient tumours. ; This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska‐Curie grant agreement No. 722729. Research in M.T. laboratory is supported by Cancer Research UK, Medical Research Council and University of Oxford.