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This article belongs to the Special Issue Genetic Programming, Theory, Methods and Applications ; [Abstract] Image Enhancement (IE) is an image processing procedure in which the image's original information is improved, highlighting specific features to ease post-processing analyses by a human or machine. State-of-the-art image enhancement pipelines apply solutions to fixed and static constraints to solve specific issues in isolation. In this work, an IE system for image marketing is proposed, more precisely, real estate marketing, where the objective is to enhance the commercial appeal of the images, while maintaining a level of realism and similarity with the original image. This work proposes a generic image enhancement pipeline that combines state-of-the-art image processing filters, Machine Learning methods, and Evolutionary approaches, such as Genetic Programming (GP), to create a dynamic framework for Image Enhancement. The GP-based system is trained to optimize 4 metrics: Neural Image Assessment (NIMA) technical and BRISQUE, which evaluate the technical quality of the images; and NIMA aesthetics and PhotoILike, that evaluate the commercial attractiveness. It is shown that the GP model was able to find the best image quality enhancement (0.97 NIMA Aesthetics), while maintaining a high level of similarity with the original images (Structural Similarity Index Measure (SSIM) of 0.88). The framework has better performance according to the image quality metrics than the off-the-shelf image enhancement tool and the framework's isolated parts. ; This research was supported by Centro de Investigación de Galicia "CITIC", funded by Xunta de Galicia and the European Union (European Regional Development Fund-Galicia 2014-2020 Program), by grant ED431G 2019/01. This work is also supported by Ministry of Science and Innovation project Society Challenges (Ref. PID2020-118362RB-I00) ; Xunta de Galicia; ED431G 2019/01

[Abstract] Automatic prediction of the aesthetic value of images has received increasing attention in recent years. This is due, on the one hand, to the potential impact that predicting the aesthetic value has on practical applications. Even so, it remains a difficult task given the subjectivity and complexity of the problem. An image aesthetics assessment system was developed in recent years by our research group. In this work, its potential to be applied in commercial tasks is tested. With this objective, a set of three portals and three real estate agencies in Spain were taken as case studies. Images of their websites were taken to build the experimental dataset and a validation method was developed to test their original order with another proposed one according to their aesthetic value. So, in this new order, the images that have the high aesthetic score by the AI system will occupy the first positions of the portal. Relevant results were obtained, with an average increase of 52.54% in the number of clicks on the ads, in the experiment with Real Estate portals. A statistical analysis prove that there is a significant difference in the number of clicks after selecting the images with the AI system. ; This work is supported by the General Directorate of Culture, Education and University Management of Xunta de Galicia (Ref. ED431D 201716), Competitive Reference Groups (Ref. ED431C 201849) and Ministry of Science and Innovation project Society challenges (Ref. PID2020-118362RB-I00). We also wish to acknowledge the support received from the Centro de Investigación de Galicia "CITIC", funded by Xunta de Galicia and the European Union (European Regional Development Fund- Galicia 2014-2020 Program), by grant ED431G 2019/01 ; Xunta de Galicia; ED431D 201716 ; Xunta de Galicia; ED431C 201849 ; Xunta de Galicia; ED431G 2019/01

Drug discovery aims at finding new compounds with specific chemical properties for the treatment of diseases. In the last years, the approach used in this search presents an important component in computer science with the skyrocketing of machine learning techniques due to its democratization. With the objectives set by the Precision Medicine initiative and the new challenges generated, it is necessary to establish robust, standard and reproducible computational methodologies to achieve the objectives set. Currently, predictive models based on Machine Learning have gained great importance in the step prior to preclinical studies. This stage manages to drastically reduce costs and research times in the discovery of new drugs. This review article focuses on how these new methodologies are being used in recent years of research. Analyzing the state of the art in this field will give us an idea of where cheminformatics will be developed in the short term, the limitations it presents and the positive results it has achieved. This review will focus mainly on the methods used to model the molecular data, as well as the biological problems addressed and the Machine Learning algorithms used for drug discovery in recent years.