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This article deals with the emergence of social sciences in Spain at the end of the nineteenth century. It focuses on the Royal Academy of moral and political sciences, whose creation in 1857, on the French model, was part of the reorganisation of public education, but also an ideological reaction of the conservative party (partido moderado), which returned to power after the 1854-1956 Revolution. The Academy was officially in charge of propagating the political doctrines of the regime (namely "doctrinaire" liberalism) and of countering socialism at the scientific level. This paper shows the methodological relevance of studying such a multidisciplinary institution in order to grasp simultaneously the pluralistic scientific matrix of the social sciences as well as the political issues that surround them. It analyses the content and the evolution of moral and political sciences between 1857 and 1923 and highlights the multiple factors that played an active role in the emergence of the social sciences: the legacy of former scholarly disciplines, the impact of the propagation of naturalistic theories during the liberal revolution of 1868, and the critique of liberalism and liberal sciences following the social and political crisis from the 1880s onwards. ; Este artículo examina la cuestión de la institución de las ciencias sociales en España al final del siglo XIX. Lo hace a través del estudio de la Real Academia de ciencias morales y políticas, creada en 1857 según un modelo francés, instrumento de la reforma liberal de la Intrucción pública y de la reacción ideológica del partido moderado despues de la révolution de 1854-1856. La función oficial de la Academia era la difusión de la doctrina política del régimen (el liberalismo doctrinario) y la refutación científica del socialismo. Intentamos demostrar el intérés metodológico de su estudio para conocer las raices disciplinares multiples de las ciencias sociales y los debates políticos que determinaron su institucionalización. La evolución de las ciencias morales y politicas entre 1857 y 1923 permite entender los elementos que participaron a la formación de las ciencias sociales : el legado de las disciplinas que les precedieron, el impacto de la difusión de las teorías naturalistas (evolucionismo) durante la Revolución de 1868, y la crítica del liberalismo y de las ciencias liberales, enfrentadas a la « cuestión social » a partir de los años 1880.This article deals with the emergence of social sciences in Spain at the end of the nineteenth century. It focuses on the Royal Academy of moral and political sciences, whose creation in 1857, on the French model, was part of the reorganisation of public education, but also an ideological reaction of the conservative party (partido moderado), which returned to power after the 1854-1956 Revolution. The Academy was officially in charge of propagating the political doctrines of the regime (namely "doctrinaire" liberalism) and of countering socialism at the scientific level. This paper shows the methodological relevance of studying such a multidisciplinary institution in order to grasp simultaneously the pluralistic scientific matrix of the social sciences as well as the political issues that surround them. It analyses the content and the evolution of moral and political sciences between 1857 and 1923 and highlights the multiple factors that played an active role in the emergence of the social sciences: the legacy of former scholarly disciplines, the impact of the propagation of naturalistic theories during the liberal revolution of 1868, and the critique of liberalism and liberal sciences following the social and political crisis from the 1880s onwards.

Glutamoptosis is the induction of apoptotic cell death as a consequence of the aberrant activation of glutaminolysis and mTORC1 signaling during nutritional imbalance in proliferating cells. The role of the bioenergetic sensor AMPK during glutamoptosis is not defined yet. Here, we show that AMPK reactivation blocks both the glutamine-dependent activation of mTORC1 and glutamoptosis in vitro and in vivo. We also show that glutamine is used for asparagine synthesis and the GABA shunt to produce ATP and to inhibit AMPK, independently of glutaminolysis. Overall, our results indicate that glutamine metabolism is connected with mTORC1 activation through two parallel pathways: an acute alpha-ketoglutarate-dependent pathway; and a secondary ATP/AMPK-dependent pathway. This dual metabolic connection between glutamine and mTORC1 must be considered for the future design of therapeutic strategies to prevent cell growth in diseases such as cancer. ; This work was supported by funds from the following institutions: Agencia Estatal de Investigación/European Regional Development Fund, European Union (PGC2018-096244- B-I00, SAF2016-75442-R), Ministry of Science, Innovation and Universities of Spain, Spanish National Research Council—CSIC, Institut National de la Santé et de la Recherche Médicale —INSERM, Université de Bordeaux, Fondation pour la Recherche Médicale, the Conseil Régional d'Aquitaine, SIRIC-BRIO, Fondation ARC, and Institut Européen de Chimie et Biologie. C.B. was recipient of fellowships from the Minister of Higher Education, Research and Innovation (France) and the Fondation ARC (France).

Glutamoptosis is the induction of apoptotic cell death as a consequence of the aberrant activation of glutaminolysis and mTORC1 signaling during nutritional imbalance in proliferating cells. The role of the bioenergetic sensor AMPK during glutamoptosis is not defined yet. Here, we show that AMPK reactivation blocks both the glutamine-dependent activation of mTORC1 and glutamoptosis in vitro and in vivo. We also show that glutamine is used for asparagine synthesis and the GABA shunt to produce ATP and to inhibit AMPK, independently of glutaminolysis. Overall, our results indicate that glutamine metabolism is connected with mTORC1 activation through two parallel pathways: an acute alpha-ketoglutarate-dependent pathway; and a secondary ATP/AMPK-dependent pathway. This dual metabolic connection between glutamine and mTORC1 must be considered for the future design of therapeutic strategies to prevent cell growth in diseases such as cancer. ; This work was supported by funds from the following institutions: Agencia Estatal de Investigación/European Regional Development Fund, European Union (PGC2018-096244- B-I00, SAF2016-75442-R), Ministry of Science, Innovation and Universities of Spain, Spanish National Research Council—CSIC, Institut National de la Santé et de la Recherche Médicale —INSERM, Université de Bordeaux, Fondation pour la Recherche Médicale, the Conseil Régional d'Aquitaine, SIRIC-BRIO, Fondation ARC, and Institut Européen de Chimie et Biologie. C.B. was recipient of fellowships from the Minister of Higher Education, Research and Innovation (France) and the Fondation ARC (France). We thank Prof. Patricia Boya (Centro de Investigaciones Biologicas, Madrid, Spain) for kindly providing with the ATG5+/+ and ATG5−/− MEFs. We thank Prof. Benoit Viollet (Institute Cochin, Paris, France) for kindly providing with the AMPK+/+ and AMPK−/− MEFs, and the CA-AMPK plasmid.