Affective commitment among knowledge workers: the role of pay satisfaction and organization career management
In: International journal of human resource management, Band 24, Heft 20, S. 3903-3920
ISSN: 1466-4399
12 Ergebnisse
Sortierung:
In: International journal of human resource management, Band 24, Heft 20, S. 3903-3920
ISSN: 1466-4399
In: Environmental science and pollution research: ESPR, Band 25, Heft 10, S. 9662-9672
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 25, Heft 7, S. 6980-6989
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 24, Heft 7, S. 6698-6709
ISSN: 1614-7499
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 237, S. 113518
ISSN: 1090-2414
In: Environmental science and pollution research: ESPR, Band 27, Heft 24, S. 30178-30189
ISSN: 1614-7499
In: Waste management: international journal of integrated waste management, science and technology, Band 103, S. 260-267
ISSN: 1879-2456
In: Waste management: international journal of integrated waste management, science and technology, Band 76, S. 106-116
ISSN: 1879-2456
In: info:eu-repo/semantics/altIdentifier/doi/10.2147/IJN.S38937
Qunyou Tan,1,* Dan He,2,* Mingjun Wu,2,* Lin Yang,3 Yong Ren,4 Juan Liu,2 Jingqing Zhang,21Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 2Medicine Engineering Research Center, Chongqing Medical University, Chongqing, 3Chongqing Institute for Food and Drug Control, Chongqing, 4Center of Drug Discovery, Nanjing Normal University, Nanjing, People's Republic of China*These authors contributed equally to this workBackground: The purpose of this study was to develop, characterize, and investigate a molecular inclusion complex containing rifaldazine with good solubility and antibacterial activity.Methods: Rifaldazine, a lipophilic molecule, was encapsulated into the hydrophobic cavity of ß-cyclodextrin to form a molecular inclusion complex (RAABCD) with good solubility. RAABCD was prepared in a short time using a solid-state grinding method. The inclusion ratio, binding constant, and change in Gibbs free energy were determined by a phase solubility diagram and/or ultraviolet-visible spectroscopy. Differential scanning calorimetry and Fourier transform infrared spectroscopy of RAABCD were performed. Morphological features of RAABCD were observed by photomicroscopy. The most likely optimal configuration for RAABCD was simulated by computer modeling. Broth macrodilution testing was done to investigate the antibacterial activity of RAABCD.Results: The inclusion ratio, binding constant, and change in Gibbs free energy, determined by a phase solubility diagram and/or ultraviolet-visible spectroscopy were 1:1, 288.33/261.33 L/mol, and 32.29/31.73 kJ/mol, respectively. Differential scanning calorimetry and Fourier transformed infrared spectra of RAABCD confirmed the molecular interaction between rifaldazine and ß-cyclodextrin. The morphological difference between irregular and amorphous-shaped RAABCD and columnar-shaped rifaldazine further confirmed the molecular encapsulation of rifaldazine. The most likely optimal configuration for RAABCD was confirmed by computer modeling. Broth macrodilution testing indicated that RAABCD had good antibacterial activity.Conclusion: RAABCD had improved solubility and good activity, and might be a promising alternative for treatment of a range of bacterial infections.Keywords: rifaldazine, cyclodextrin inclusion complex, stoichiometric relationships, differential scanning calorimetry, Fourier transform infrared spectra, computer modeling
BASE
In: Environmental science and pollution research: ESPR, Band 30, Heft 10, S. 28227-28237
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 28, Heft 44, S. 62030-62060
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 30, Heft 39, S. 91095-91107
ISSN: 1614-7499