Suchergebnisse

Astaxanthin was a beneficial carotenoid in the nutraceutical, food, cosmetics, and feed industries. The new astaxanthin infused topical moisturizer was developed using astaxanthin, Manuka honey, and Neutrogena Hydro Boost gel moisturizer. The astaxanthin was extracted from Haematococcus pluvialis subjected to the in-house astaxanthin extraction procedure developed by the Microalgae Research Laboratory, UiTM Puncak Alam, Selangor. Fifteen topical moisturizer samples were developed via Box-Behnken Design. The moisturizer properties were significantly influenced by astaxanthin, Neutrogena Hydro Boost gel moisturizer, and Manuka honey content based on the User Acceptance Survey done on 250 respondents. This study observed response surface regression, analysis of variance, and response optimization for appearance, aroma/smell, and texture. The optimum levels of the three factors were astaxanthin is at 1 ml, Neutrogena Hydro Boost gel moisturizer is at 20 ml, and Manuka honey must be less than 10 g which is at 0.9192g, as 69% of respondents like the composition.

Trigonella foenum-graecum (TFG) is a significant leguminous plant with diverse pharmacological effects. However, the resistant character of this plant accounts for significant difficulties in vitro multiplication, justifying the necessity to try new techniques for in vitro propagation of this plant. Hence, this study reports the effects of BAP, NAA, and 2,4-D on in vitro callus formation of seeds. The toxicity properties of seeds, plant, and callus aqueous extracts of TFG were measured by brine shrimp assay (BSA). Callus index, frequency of callus, callus weight, and morphology of callus were recorded after 30 days of culture. No callus formation was observed in the absence of plant growth regulators. The maximum callus formation observed in the MS media containing 1.0 mg/l 2,4-D, the highest mean of the callus index (52±9.5) with 100% frequency and callus yield (0.52±0.08 g) in 30 days of culture. The highest mean of callus index (37±0 4.05) for combination hormones with 100% callusing and yield (0.37±0.02 g) in 30 days of culture by 1.0 mg/l BAA with 0.5 mg/l NAA. Seeds extract of TFG showed the highest toxicity (954.99 µg/ml), aqueous plant extract (1237.98 µg/ml), and aqueous callus extract (1801 µg/ml) from BSA. Comparing individual hormones, the highest amount of callus in TFG can be yielded 2,4-D hormone alone, and a combination of BAP and NAA can yield 100% callus.

The COVID-19 outbreak has struck the world and has led to mortalities worldwide. On top of that, cancer diseases are the other major cause of death globally. Scientists around the globe are racing to find possible therapeutic compounds that could alleviate or manage these diseases. Searching for the potential compounds to be utilised as a treatment for SARS-CoV-2 infection and immunotherapies for cancer is in line with achieving a healthy community. The healthy community concept aims to reduce health gaps regardless of the status quo within a community. In making this concept a success, the ability to recover from health disasters such as cancer and the COVID-19 outbreak is one of the indicators. It could be achieved when humans are supplemented with proper nutrients to help manage these diseases. Studies have suggested that compounds exhibiting anti-inflammatory and antioxidant properties could help to reduce the inflammation caused by the SARS-CoV-2 infection while enhancing the immune system to address cancer diseases. The current work will review the anti-inflammatory properties of astaxanthin, tocotrienols and tocopherols, plus the beta-carotene and fucoxanthin's antioxidant properties. The potential of the studied compounds to be utilised as cancer immunotherapies will be further evaluated, as these compounds have also been reported to exhibit anti-cancer properties. The findings of this study will indicate the potential of these five compounds in managing SARS-CoV-2 infection and act as cancer immunotherapies in achieving a healthy community.