Suchergebnisse

Ebolavirus disease (EVD) cases may go unreported because they are asymptomatic or unrecognized. We present serologic evidence of Ebolavirus exposure in a population residing in non-EBOV outbreak locations in DRC and identify activities and animal exposures associated with EBOV seropositivity.

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Research Resettlement Fund for the new faculty, the Research Institute for Veterinary Science ; BK21 PLUS Program for Creative Veterinary Science Research Center, Seoul National University ; National Research Foundation of Korea (NRF) grant - Korea government (MSIT) ; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) ; Processo FAPESP: 14/15307-7 ; National Research Foundation of Korea (NRF) grant - Korea government (MSIT): 2018R1A2B2002923 ; CAPES: BEX 3159/14-0 ; Naturally-occurring chalcones and synthetic chalcone analogues have been demonstrated to have many biological effects, including anti-inflammatory, anti-malarial, anti-fungal, and anti-oxidant/anti-cancerous activities. Compared to other chalcones, trans-chalcone exhibits superior inhibitory activity in cancer cell growth as shown via in vitro assays, and exerts anti-cancerous effects via the activation of the p53 tumor suppressor protein. Thus, characterization of the specific mechanisms, by which trans-chalcone activates p53, can aid development of new chemotherapeutic drugs that can be used individually or synergistically with other drugs. In this report, we found that trans-chalcone modulates many p53 target genes, HSP40 being the most induced gene in the RNA-Seq data using trans-chalcone-treated cells. CRM1 is also inhibited by trans-chalcone, resulting in the accumulation of p53 and other tumor suppressor proteins in the nucleus. Similar effects were seen using trans-chalcone derivatives. Overall, trans-chalcone could provide a strong foundation for the development of chalcone-based anti-cancer drugs.