Antibiotic residues and safety of fish meat treated with fluoroquinolones
Over the past few decades quinolones are the most dynamically developed group of synthetic antimicrobials. They are also known as 4-quinolone, quinolone carboxylic acids and fluoroquinolones. They have excellent activity against gram-negative and gram-positive bacteria. Therefore they are the most commonly used classes of antibiotics in clinical medicine. Problem of most importance in fish is the effective control of infectious diseases. Thus the essential strategy is the use of antimicrobial agents. In the same time quinolones are preferred group for treatment of bacterial diseases in fish. Literature data show a disturbing perspective – the increase of cases of uncontrolled use of antimicrobials, which leads to danger for consumers, despite of definitive legislation in this area. Data of many authors show a great number of productive animals receive antimicrobials for food and therapeutic purposes. This is in connection to the uncontrolled sale of antibiotics in the veterinary pharmacies and their use by owners to treat their animal. The withdrawal periods are not respected. Therefore, the presence of residues of antimicrobial substances in meat and meat products, milk and dairy products, fish, eggs and honey are not uncommon. In series of studies enrofloxacin and ciprofloxacin residues have been identified in meat of two fish species: rainbow trout (Oncorhynhus mykiss) and common (cultural) carp (Cyprinus carpio) during storage. Pharmacokinetic studies have been carried out during storage. The results for enrofloxacin residues in trout meat during frozen storage determined a distinguished decrease after 180th day, while ciprofloxacin residues established a long time reduction to 270th day of the storage. Otherwise, the presence of enrofloxacin and ciprofloxacin residues in common carp meat showed the amount of enrofloxacin in 1st month of the study changed scarcely. In three months at a temperature of minus 18 ° C it was established a distinguished decrease of enrofloxacin. It was maintained until the end of ...