Suchergebnisse

Mississippi in 1965: the struggle for the right to vote -- Mississippi's massive resistance to Black political empowerment -- The judicial response to massive resistance: Allen v. State board of elections -- The struggle against discriminatory legislative redistricting -- The impact of the struggle for Black political participation on Mississippi politics -- The impact of Mississippi legislation on national voting rights law -- Race and Mississippi politics: changes and continuitites

AbstractIntroductionOral bisphosphonates are first‐line agents for treating osteoporosis in men, but there are no studies regarding efficacy of oral bisphosphonates for treatment of osteoporosis in ambulatory male adults with intellectual disability.MethodsNine adult males with intellectual disability and increased fracture risk had been treated with weekly or monthly oral bisphosphonates, vitamin D and calcium for 1–3 years. Post‐treatment bone mineral density (BMD), serum 25(OH)D, parathyroid hormone and C‐telopeptide of type I collagen were then determined for the first time.ResultsWeekly or monthly oral bisphosphonates were well tolerated and led to significant increases in BMD in all 9 individuals. Serum 25(OH)D level enhanced the "pecent increase of BMD" that occurred in response to bisphosphonate treatment (p < .05).ConclusionsWeekly or monthly oral bisphosphonates are well tolerated by ambulatory adult males with ID and are effective in increasing BMD. Higher serum levels of vitamin D appear to improve the efficacy of bisphosphonates and therefore reduce fracture risk in adult males with intellectual disability.