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The size of the world's population has profound implications for demand for food, energy and resources, land use change and greenhouse gas emissions. This study examines why most population projections have underestimated world population growth, and the implications for actions required to achieve sustainable societies. The main determinant of future population is family size choices. Population projections by different research groups embed different assumptions about drivers of fertility decline. The common assumptions that fertility decline is driven by economic betterment, urbanisation or education levels are not well supported in historical evidence. In contrast, voluntary family planning provision and promotion achieved rapid fertility decline, even in poor, rural and illiterate communities. Projections based on education and income as drivers of fertility decline ignore the reverse causation, that lowering fertility through family planning interventions enabled economic advancement and improved women's education access. In recent decades, support for family planning has waned, and global fertility decline has decelerated as a result. Projections calibrated across the decades of strong family planning support have not acknowledged this change and are consequently underestimating global population growth. Scenarios used to model sustainable futures have used overly optimistic population projections while inferring these outcomes will happen without targeted measures to bring them about. Unless political will is rapidly restored for voluntary family planning programs, the global population will almost certainly exceed 10 billion, rendering sustainable food security and a safe climate unachievable.

While most analyses of economic impacts of population growth have been equivocal, this article describes a new perspective from which the effects are strongly negative. The economies and diseconomies of population size are largely circumstantial and empirically inconsistent, but those of growth rate are intrinsic and consistent. These impacts are not apparent on income and per capita GDP, but on costs. The article estimates these costs using the logic of calculus rather than marginal accounting. Specifically, the cost of maintaining per capita capacity of durable assets, including infrastructure, equipment and skilled personnel, is increased by population growth by a factor proportional to the working lifespan of the asset class.

Popular representations of the workplace have tended to construct women as unsuited to management and leadership roles. In their reflective capacity these popular fictional texts illustrate the workplace. In their capacity to construct popular perceptions of "reality", the texts offer an important insight into women's and men's understandings and expectations of their workplace relationships. In this article we reflect on how popular films, plays and television shows can make visible some manifestations of the kinds of resistance women continue to experience in non‐traditional domains such as management. While these kinds of texts have not been central to the analysis of workplace relations within the management literature, we argue that as social documents they have much to contribute to an understanding of the limited advancement of women.

Driven by increasing consumption and population numbers, human demands are depleting natural resources essential to support human life, causing damage to crop lands, fresh water supplies, fisheries, and forests, and driving climate change. Within this century, world population could increase by as little as 15% or by more than 50%, depending largely on how we respond. We must face the challenge of accommodating these additional people at the same time as virtually eliminating the use of fossil fuels and other activities that generate greenhouse gases, reversing environmental degradation and supporting improved living standards for billions of impoverished people. The response to this challenge is handicapped by a lack of common understanding and an integrated agenda among those contributing to the response. This report offers a strategy to protect natural systems and improve welfare through expansion of reproductive justice, a concept that includes family planning, reproductive health, and gender equity, and preservation of the environment and climate.

The authors thank the observers of the PKWP who have supported the development of the PSBGL and also Efthymios Manolis, Quirine Fillekes, and Milton Bonelli for constructive comments. Pharmacokinetics Working Party: Ridha Belaiba (ANSM, France); Eva-Gil Berglund (MPA, Sweden); Susan Cole (MHRA, UK); Alfredo García-Arieta (AEMPS, Spain); Sotiris Michaleas (Ministry of Health Pharmaceutical Services, Cyprus); Janet Mifsud (Medicines Authority, Malta); Jan Neuhauser (AGES, Austria); Henrike Potthast (BfArM, Germany); Carolien Versantvoort (MEB, The Netherlands). ; The European Medicines Agency's (EMA) product-specific bioequivalence guidelines outline harmonized regulatory requirements for studies to demonstrate bioequivalence for products that may have particular needs due to their pharmacokinetics, in addition to those outlined in general guidance. As such they are potentially very useful to the pharmaceutical industry in the development of generic medicinal products and to regulatory authorities for harmonized decision-making. Since their introduction in 2013, EMA product-specific bioequivalence guidelines continue to increase in number, and as of June 2017, encompass a number of different pharmacotherapeutic groups and pharmaceutical forms. This article further elucidates the processes involved for stakeholders and reviews the Agency's experience with the development of these guidelines, including the scientific issues witnessed with their advancement. A comparison with the United States Food and Drug Administration approach to similar guidelines is also provided. ; peer-reviewed

A currently popular lifestyle television show (Escape from the City) on Australia's national public service broadcaster, the ABC, highlights the limitations of popular cultural representations of life in a regional centre. The program is targeted at viewers interested in relocating to regional Australia. As Raymond Boyle and Lisa Kelly note, popular television is an important entry point into the construction of public knowledge as well as a launching point for viewers as they seek additional information (65). In their capacity to construct popular perceptions of 'reality', televisual texts offer a significant insight into our understandings and expectations of what is going on around us. Similar to the concerns raised by Esther Peeren and Irina Souch in their analysis of the popular TV show Farmer Wants a Wife (a version set in the Netherlands from 2004-present), we worry that these shows "prevent important aspects of contemporary rural life from being seen and understood" (37) by the viewers, and do a disservice to regional communities. For the purposes of this article, we interrogate the episodes of Escape from the City screened to date in terms of the impact they may have on promoting regional Australia and speculate on how satisfied (or otherwise) we would be should the producers direct their lens onto our regional community-Armidale, in northern NSW. We start with a brief précis of Escape from the City and then, applying an autoethnographic approach (Butz and Besio) focusing on our subjective experiences, we share our reflections on living in Armidale. We blend our academic knowledge and knowledge of everyday life (Klevan et al.) to argue there is greater cultural diversity, complexity, and value in being in the natural landscape in regional areas than is portrayed in these representations of country life that largely focus on cheaper real estate and a five-minute commute. We employ an autoethnographic approach because it emphasises the socially and politically constituted nature of knowledge claims and ...

'We have kicked the can down the road once again – but we are running out of road.' – Rachel Kyte, Dean of Fletcher School at Tufts University. We, in our capacities as scientists, economists, governance and policy specialists, are shifting from warnings to guidance for action before there is no more 'road.' The science is clear and irrefutable; humanity is in advanced ecological overshoot. Our over exploitation of resources exceeds ecosystems'capacity to provide them or to absorb our waste. Society has failed to meet clearly stated goals of the UN Framework Convention on Climate Change. Civilization faces an epochal crossroads, but with potentially much better, wiser outcomes if we act now. What are the concrete and transformative actions by which we can turn away from the abyss? In this paper we forcefully recommend priority actions and resource allocation to avert the worst of the climate and nature emergencies, two of the most pressing symptoms of overshoot, and lead society into a future of greater wellbeing and wisdom. Humanity has begun the social, economic, political and technological initiatives needed for this transformation. Now, massive upscaling and acceleration of these actions and collaborations are essential before irreversible tipping points are crossed in the coming decade. We still can overcome significant societal, political and economic barriers of our own making. Previously, we identified six core areas for urgent global action – energy, pollutants, nature, food systems, population stabilization and economic goals. Here we identify an indicative, systemic and time-limited framework for priority actions for policy, planning and management at multiple scales from household to global. We broadly follow the 'Reduce-Remove-Repair' approach to rapid action. To guide decision makers, planners, managers, and budgeters, we cite some of the many experiments, mechanisms and resources in order to facilitate rapid global adoption of effective solutions. Our biggest challenges are not technical, but social, economic, political and behavioral. To have hope of success, we must accelerate collaborative actions across scales, in different cultures and governance systems, while maintaining adequate social, economic and political stability. Effective and timely actions are still achievable on many, though not all fronts. Such change will mean the difference for billions of children and adults, hundreds of thousands of species, health of many ecosystems, and will determine our common future.