Suchergebnisse

TMIT classification did not have additional prognostic value over CD8+ TILs alone. The modest percentage of CD8high/PD-L1pos cases indicates that ITAC is a lowly immunogenic tumour type. Nevertheless, a proportion of ITAC, especially the papillary and colonic subtypes, could benefit from therapy with immune checkpoint inhibitors. ; Supported by grants CICPF16008HERM of Fundación AECC, IDI2018/155 Ayudas a Grupos PCTI Principado de Asturias, and CB16/12/00390 from the Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Spain. Plan Nacional de I+D+I 2013-2016 of the Plan Estatal cofinanced by the FEDER Funding Program from the European Union.

This study was supported by Grants PI13-646, PI15-1629 and PI17-763 from the Fondos de Investigacion Sanitaria (FIS) and grant CB16/12/00390 from the Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Spain. Plan Nacional de I+D+I 2013-2016 of the Plan Estatal cofinanced by the FEDER Funding Program from the European Union.

This study was supported by grants CICPF16008HERM of Fundación AECC, IDI2018/155 of Ayudas a Grupos PCTI Principado de Asturias, PI19/00191 of Fondos de Investigación Sanitaria, and CB16/12/00390 from the Centro de Investigación Biomédica en Red de Cancer (CIBERONC), Spain. Plan Nacional de I+D+I 2013-2016 of the Plan Estatal cofinanced by the FEDER Funding Program from the European Union.

The authors thank Paul van Diest, Dept Pathology, University Medical Centre Utrecht, The Netherlands for contributing tumour samples, and the technicians Laura Suarez Fernandez and Aitana Vallina for creating the tissue microarray. This work was supported by Instituto de Salud Carlos III (Grants PI13-646 and PI15-1629); Red Tematica de Investigacion Cooperativa en Cancer (Grant RD12/0036/0015) and CIBERONC (CB16/12/00390), Spain. Plan Nacional de I + D + I 2008-2011 o el Plan Estatal de I + D + I 2013-2016, cofinanced by the FEDER Funding Program from the European Union.