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[EN] Ceria nanoparticles are cell compatible antioxidants whose activity can be enhanced by gold deposition and by surface functionalization with positive triphenylphosphonium units to selectively target the mitochondria. The antioxidant properties of these nanoparticles can serve as the basis of a new strategy for the treatment of several disorders exhibiting oxidative stress, such as cancer, diabetes or Alzheimer's disease. However, all of these pathologies require a specific antioxidant according with their mechanism to remove oxidant species excess in cells and diminish their effect on mitochondrial function. The mechanism through which ceria nanoparticles neutralize oxidative stress and their effect on mitochondrial function have not been characterized yet. In the present study, the mitochondria antioxidant effect of ceria and ceria-supported gold nanoparticles, with or without triphenylphosphonium functionalization, was assessed in HeLa cells. The effect caused by ceria nanoparticles on mitochondria function in terms of mitochondrial membrane potential (Delta Psi m), adenosine triphosphate (ATP) production, nuclear respiratory factor 1 (NRF1) and nuclear factor erythroid-2 like 1 (NFE2L1) was reversed by the presence of gold. Furthermore, this effect was enhanced when nanoparticles were functionalized with triphenylphosphonium. Our study illustrates how the mitochondrial antioxidant effect induced by ceria nanoparticles can be modulated by the presence of gold. ; This research was funded by Carlos III Health Institute and the European Regional Development Fund, grant number CP13/00252 and PI16/1083; the Catalonian Agency for Management of University and Research Grants, grant number 2017SGR1303; the Ministry of Education of the Valencian Regional Government, grant number PROMETEO/2019/027, The Foundation for the Promotion of Health and Biomedical Research of Valencia Region, grant number Nanobetes2. ; Gutiérrez-Carcedo, P.; Navalón Oltra, S.; Simó, R.; Setoain, X.; Aparicio-Gómez, C.; Abasolo, I.; Victor, ...

[EN] Herein we report the synthesis of a tetrathiafulvalene (TTF)-based MOF, namely MUV-2, which shows a non-interpenetrated hierarchical crystal structure with mesoporous one-dimensional channels of ca. 3 nm and orthogonal microporous channels of ca. 1 nm. This highly stable MOF (aqueous solution with pH values ranging from 2 to 11 and different organic solvents), which possesses the well-known [Fe3(¿3-O)(COO)6] secondary building unit, has proven to be an efficient catalyst for the aerobic oxidation of dibenzothiophenes. ; The work has been supported by the European Union (ERC-2016-CoG 724681-S-CAGE) and the Spanish MINECO (CTQ 2014-59209-P, CTQ2017-89528-P and MAT2015-71842-P). We also thank the Spanish government for the provision of a Severo Ochoa project (SEV-2016-0683) and a Maria de Maeztu project (MDM-2015-0538). G.M.E. and M.S. thank MINECO for a Ramon y Cajal and a Juan de la Cierva-Formacion fellowships, respectively. We thank J. M. Martinez-Agudo, G. Agusti and J. Romero from the University of Valencia for their magnetic and cyclic voltammetry measurements. We thank the Diamond Light Source (UK) for the synchrotron beamtime. C2TN/IST authors acknowledge the Portuguese Foundation for Science and Technology (FCT), contract UID/Multi/04349/2013. ; Souto, M.; Santiago-Portillo, A.; Palomino Roca, M.; Vitorica-Yrezabal, IJ.; Vieira, BJC.; Waerenborgh, JC.; Valencia Valencia, S. (2018). A highly stable and hierarchical tetrathiafulvalene-based metal organic framework with improved performance as a solid catalyst. Chemical Science. 9(9):2413-2418. https://doi.org/10.1039/c7sc04829g ; S ; 2413 ; 2418 ; 9 ; 9 ; Furukawa, H., Cordova, K. E., O'Keeffe, M., & Yaghi, O. M. (2013). The Chemistry and Applications of Metal-Organic Frameworks. Science, 341(6149), 1230444-1230444. doi:10.1126/science.1230444 ; Zhou, H.-C. «Joe», & Kitagawa, S. (2014). Metal–Organic Frameworks (MOFs). Chem. Soc. Rev., 43(16), 5415-5418. doi:10.1039/c4cs90059f ; Maurin, G., Serre, C., Cooper, A., & Férey, G. (2017). The new ...