Suchergebnisse

Intro -- PLASMODIUM FALCIPARUM: MORPHOLOGY, LIFE CYCLE AND HEALTH IMPACT -- PLASMODIUM FALCIPARUM: MORPHOLOGY, LIFE CYCLE AND HEALTH IMPACT -- Library of Congress Cataloging-in-Publication Data -- Contents -- Chapter I: Recent Advances in Vaccine Development against Malaria Caused by Plasmodium Falciparum -- Abstract -- Introduction -- Immunity to Malaria Infection -- The Complexities of the Plasmodium Life Cycle -- Immunity to Different Parasite Stages -- Malaria Vaccine Development: Some Historical Landmarks -- Vaccine Targets Associated with Different Plasmodium Stages -- Vaccines That Target the Pre-Erythrocytic Stages -- Vaccines that Target Erythrocytic Stages -- Vaccines that Target Sexual Stages -- Vaccines that Combine Antigens from Different Stages -- Conclusion -- Acknowledgments -- References -- Chapter II: Role of Heat Shock Proteinsin the Development and Pathogenicity of Plasmodium Falciparum -- Abstract -- 1. Introduction -- 2. Hsp110 -- 2. Hsp110 -- 4. Small Heat Shock Proteins -- 4. Small Heat Shock Proteins -- 6. Hsp90 -- 7. Hsp70 -- 8. Hsp40 Co-Co-Chaperones -- Conclusion -- Acknowledgments -- References -- Chapter III: Isoprenoid Biosynthesis in the Erythrocytic Stages of Plasmodium falciparum -- Abstract -- 1. Introdution -- 2. Isoprenoids -- 3. Methodology for Characterization of the Isoprenoid Pathway in P. falciparum -- 4. Mevalonate-Independent Methylerythritol Phosphate (MEP) Pathway in P. falciparum -- 5. Biosynthesis of Isoprenoids in P. falciparum -- 6. Post-Translational Modification in P. falciparum -- Conclusion -- Acknowledgments -- References -- Chapter IV: Maurer's Clefts of Plasmodium Falciparum: Unraveling its Morphology -- Abstract -- Introduction -- Maurer's Clefts - Discovery and Function -- New Technological Approaches to Refine the Structure of MCs -- Conclusion -- Acknowledgments -- References.

Johanna M Porter-Kelley1, Joann Cofie2, Sophonie Jean2, Mark E Brooks1, Mia Lassiter1, DC Ghislaine Mayer21Life Sciences Department, ­Winston-Salem State University, Winston Salem, NC, USA; 2Department of Biology, Virginia Commonwealth University, Richmond, VA, USAAbstract: Malaria, a disease of poverty and high morbidity and mortality in the tropical world, has led to a worldwide search for control measures. To that end, good antimalarial chemotherapies have been difficult to find in the global market and those that seem to be most effective are rapidly becoming ineffective due to the emergence and spread of drug resistance. Artemisinin, a very effective yet expensive antimalarial, has quickly become the recommended drug of choice when all other possibilities fail. However, for all its promise as the next great antimalarial, the outlook is bleak. Resistance is developing to artemisinin while another effective antimalarial is not in sight. Malaria endemic areas which are mostly in developing countries must deal with the multifaceted process of changing and implementing new national malaria treatment guidelines. This requires complex interactions between several sectors of the affected society which in some cases take place within the context of political instability. Moreover, the cost associated with preventing and containing the spread of antimalarial resistance is detrimental to economic progress. This review addresses the impact of artemisinin resistance on the socioeconomic structure of malaria endemic countries.Keywords: artemisinin-based drugs, social, economic, malarial parasite resistance