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Résumé Objectif : L'exposition de la population aux rayonnements ionisants est une préoccupation croissante des autorités sanitaires françaises et internationales. L'objectif de ce travail est de réaliser une synthèse des recommandations de bonne prescription des examens irradiants et de prise en charge des patients exposés aux rayonnements ionisants d'origine professionnelle. Méthodes : Synthèse méthodique de la littérature par interrogation des bases CISMeF et PubMed. Sélection des recommandations de pratique clinique, des guides produits par les institutions sanitaires françaises, et des articles concernant les prescriptions d'examens irradiants en soins primaires. Inclusion des documents jugés pertinents ou utiles à la pratique du médecin généraliste. Exclusion des documents traitant de la radiothérapie. Résultats : Sur 386 documents sélectionnés, nous en avons retenu 20 pour l'analyse. Une meilleure utilisation des techniques d'imagerie médicale suppose une justification des actes prescrits, un transfert des techniques d'imagerie vers des examens non irradiants ainsi qu'une reconnaissance des patients à risque. De plus, une coopération accrue entre les médecins prescripteurs et les radiologues semble nécessaire et serait envisageable dans le cadre juridique actuel. La reconnaissance d'une maladie professionnelle liée à une exposition aux rayonnements ionisants peut être facilitée par une sensibilisation des acteurs de santé, accompagnée si besoin d'une collaboration avec le médecin du travail. Conclusion : Les perspectives d'amélioration de la radioprotection médicale française reposent sur la diffusion d'une « culture radiologique » auprès des médecins concernés, ainsi que sur le développement d'une meilleure coordination entre les différents acteurs de santé. Prat Organ Soins. 2010;41(3):231-236

Transportation analysis is typically thought of as one kind of spatial analysis. A major point of departure in understanding problems in transportation analysis is the recognition that spatial analysis has some limitations associated with the discretization of space. Among them, modifiable areal units and boundary problems are directly or indirectly related to transportation planning and analysis through the design of traffic analysis zones (TAZs). The modifiable boundary and the scale issues should all be given specific attention during the specification of a TAZ because of the effects these factors exert on statistical and mathematical properties of spatial patterns (ie the modifiable areal unit problem—MAUP). The results obtained from the study of spatial data are not independent of the scale, and the aggregation effects are implicit in the choice of zonal boundaries. The delineation of zonal boundaries of TAZs has a direct impact on the reality and accuracy of the results obtained from transportation forecasting models. In this paper the MAUP effects on the TAZ definition and the transportation demand models are measured and analyzed using different grids (in size and in origin location). This analysis was developed by building an application integrated in commercial GIS software and by using a case study (Lisbon Metropolitan Area) to test its implementabiity and performance. The results reveal the conflict between statistical and geographic precision, and their relationship with the loss of information in the traffic assignment step of the transportation planning models.

The demand of energy utilization is increasing expressively as fast as the development of countries. Besides being available everywhere and virtual inexhaustible, renewable energy is undoubtedly necessary to avoid depleting the planet's natural resources and global warming. Even considering the primordially environmental importance, the result of no emissions by renewable energy grant attractive also for political and economics statement. It should be noted the sun is the most abundant primary energy source in the planet and essential for eco-friendly process like photosynthesis, wind action, water cycle as well direct uses as electric and thermal generations. Consequently, nowadays several methodologies have been applied in order to transfer energy between the cycle and its surroundings optimizing for instance the coefficient of performance and heat exchangers. An absorption system is widely applied in these cases due to supply a unique solution for a range of technological problems from solar cooling to steam-driven refrigeration. Alternatively, this article main objective is modulating an absorption refrigeration system (ARS) which uses water-lithium bromide as a working fluid. Therefore, using the software Engineering Equation Solver (EES) is possible to obtain a thermodynamic single effect code that allows elaborating parametric analyses. In other words, performed and verified the influence of some input parameters over other output parameters. First, it was necessary to consider the cycle operating as reversible and steady state. Furthermore, it is assumed that no chemical reactions occur between water and lithium bromide. Thus, in the meantime apply the heat exchangers and a Solar Collector to receive the thermal energy and provide to the refrigeration cycle. Similarly, water from external sources was used to change heat with the fluid water-lithium bromide. Satisfactory results were founded and it enable to calculate and evaluate all system heat transfers rates and coefficient of performance. Almost all ...

International audience ; In most transport planning studies one of the first steps is the definition of a zoning scheme with which the study area is divided and the corresponding space is disaggregated. There are no clear rules on how to carry out this operation in an optimal way, and the dominating practice is to do it based on experience, trying to mix a certain degree of within-zone homogeneity and the convenience of using administrative borders as zone limits. Firstly, this paper starts by presenting a set of quality criteria for a general zoning scheme and an algorithm that constructs an initial zoning based on a sample of geo-referenced trip extreme points and improves it in successive steps according to those criteria. This kind of zoning fits perfectly well to traffic assignment purposes. But this paper will investigate an improvement of this approach in order to give a better understanding of the mobility determinants and its externalities on the environment. In doing so, the new zone is determined not only by the trips generation and distribution but also constrained by other indicators. In our case, we have selected a combination of the following: 1/ air pollution emissions, 2/ population density, 3/ work and study density and 4/ public transport accessibility. The integration of these 4 indicators allows us not only to picture the mobility within the region and to identify at the very precise level the main zones of activities and traffic exchanges. This integration relates the picture to the land use and the clustering of the economic activities location at a very discrete level. Furthermore, it relates the density of the mobility in dense, large and economically dynamic urban area to its externalities in terms of air pollution. In order to be effective for mobility analysis and policy purposes, this kind of approach cannot only rely on the cell grid unit but a hierarchical aggregation should be set up. This aggregation allows analyses within the administrative and political boundaries but with a ...

Maraviroc (MVC), the first approved CC‐chemokine receptor 5 (CCR5) antagonist, is used for treating HIV‐1‐infected patients with CCR5 tropism. MVC has been proved safe in all respects and showed beneficial effects on lipid profile of HIV patients with dislipidemia. Adipocyte dysfunction seems to be responsible for many metabolic alterations such as insulin resistance and dislipidemia. Subcutaneous and visceral fat depots are not only physiologically but also metabolically different and metabolic disturbances are more closely associated with visceral than subcutaneous fat accumulation. It has been suggested that antiretrovirals affect both fat depots in a different extent. Thus, whether isolated human adipocytes display regio‐specific sensitivity to the metabolic effects of MVC have been tested in this study. Human subcutaneous and omental preadipocytes were used as the source of human adipocytes. These cells were treated with therapeutic concentrations of MVC (0.5–25 µM) at day 14 post‐differentiation (4 and 24 hours of treatment). Glucose utilization, lactate production and glycerol released into the media were measured using an autoanalyzer. Adiponectin secretion was determined by an ELISA array. A dose‐dependent increase in glucose uptake was observed in subcutaneous adipocytes treated with MVC (+72% of stimulation for MVC 25 µM, p < 0.01). This stimulatory effect was tissue specific, as no effects were observed in omental adipocytes. MVC did not exert any significant effect on adiponectin secretion. No significant effects were observed on lactate production neither in subcutaneous nor omental adipocytes. Interestingly, 4 hours of treatment with MVC induced a significant increase in the amount of glycerol released into the media by subcutaneous adipocytes (p < 0.001), but this effect disappeared with longer exposure of adipocytes to MVC (24 h). No effects were observed on lipolysis in omental adipocytes although a slight tendency to decrease lipolysis was observed (p = 0.08). These data suggest that MVC exerts direct and differential effects on adipocytes depending on their origin. Thus, a stimulation of glucose uptake has been reported in subcutaneous but not in omental adipocytes and a slight decrease of lipolysis was observed in omental adipocytes whereas no effects were observed in subcutaneous adipocytes. These actions could underline the neutral and even beneficial effects demonstrated for MVC in lipid and glucose metabolism of HIV‐infected patients.

Resumen del trabajo presentado al Microscopy at the Frontiers of Science Congress Series (MFS), celebrado en el Parque de las Ciencias de Granada (España) del 11 al 13 de septiembre de 2019. ; This project has received funding the EU H2020 project CritCat (project ID: 686053). MCS has received funding from the European Union"s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 754510 (PROBIST). ICN2 acknowledge funding from Generalitat de Catalunya 2017 SGR 327 and the Spanish MINECO project ENE2017-85087-C3. ICN2 is supported by the Severo Ochoa program from Spanish MINECO (Grant No. SEV-2017-0706) and is funded by the CERCA Programme-Generalitat de Catalunya. ; Peer reviewed

A method to obtain robust information on short term leaching behaviour of volcanic ashes has been developed independently on the sample age. A mixed factorial design (MFD) was employed as a multivariate strategy for the evaluation of the effects of selected control factors and their interactions (amount of sample (A), contact time (B), and liquid to solid ratio or L/S (C)) on the leaching process of selected metals (Na, K, Mg, Ca, Si, Al, V, Mn, Fe, and Co) and anions (Cl - and SO 4 2-). Box plots of the data acquired were used to evaluate the reproducibility achieved at different experimental conditions. Both the amount of sample (A) and leaching time (B) had a significant effect on the element stripping whereas the L/S ratio influenced only few elements. The lowest dispersion values have been observed when 1.0g was leached with an L/S ratio equal to 10, shaking during 4h. The entire method is completed within few hours, and it is simple, feasible and reliable in laboratory conditions. © 2012 Elsevier B.V. ; This study was carried out in the framework of the PEGEFA Working Group (Catalonian Government "Grup de Recerca Consolidat" 2009-SGR-972), and was partly funded by the Project ASH of the Spanish Ministry of Science and Technology (CGL2008-00099) and the FPU Grant of the Spanish Ministry of Education of one of the authors (F. Ruggieri, Ref. AP2006-04592). ; Peer Reviewed

This N = 173,426 social science dataset was collected through the collaborative COVIDiSTRESS Global Survey – an open science effort to improve understanding of the human experiences of the 2020 COVID-19 pandemic between 30th March and 30th May, 2020. The dataset allows a cross-cultural study of psychological and behavioural responses to the Coronavirus pandemic and associated government measures like cancellation of public functions and stay at home orders implemented in many countries. The dataset contains demographic background variables as well as measures of Asian Disease Problem, perceived stress (PSS-10), availability of social provisions (SPS-10), trust in various authorities, trust in governmental measures to contain the virus (OECD trust), personality traits (BFF-15), information behaviours, agreement with the level of government intervention, and compliance with preventive measures, along with a rich pool of exploratory variables and written experiences. A global consortium from 39 countries and regions worked together to build and translate a survey with variables of shared interests, and recruited participants in 47 languages and dialects. Raw plus cleaned data and dynamic visualizations are available.

This N = 173,426 social science dataset was collected through the collaborative COVIDiSTRESS Global Survey – an open science effort to improve understanding of the human experiences of the 2020 COVID-19 pandemic between 30th March and 30th May, 2020. The dataset allows a cross-cultural study of psychological and behavioural responses to the Coronavirus pandemic and associated government measures like cancellation of public functions and stay at home orders implemented in many countries. The dataset contains demographic background variables as well as measures of Asian Disease Problem, perceived stress (PSS-10), availability of social provisions (SPS-10), trust in various authorities, trust in governmental measures to contain the virus (OECD trust), personality traits (BFF-15), information behaviours, agreement with the level of government intervention, and compliance with preventive measures, along with a rich pool of exploratory variables and written experiences. A global consortium from 39 countries and regions worked together to build and translate a survey with variables of shared interests, and recruited participants in 47 languages and dialects. Raw plus cleaned data and dynamic visualizations are available.

The COVIDiSTRESS global survey collects data on early human responses to the 2020 COVID-19 pandemic from 173 429 respondents in 48 countries. The open science study was co-designed by an international consortium of researchers to investigate how psychological responses differ across countries and cultures, and how this has impacted behaviour, coping and trust in government efforts to slow the spread of the virus. Starting in March 2020, COVIDiSTRESS leveraged the convenience of unpaid online recruitment to generate public data. The objective of the present analysis is to understand relationships between psychological responses in the early months of global coronavirus restrictions and help understand how different government measures succeed or fail in changing public behaviour. There were variations between and within countries. Although Western Europeans registered as more concerned over COVID-19, more stressed, and having slightly more trust in the governments' efforts, there was no clear geographical pattern in compliance with behavioural measures. Detailed plots illustrating between-countries differences are provided. Using both traditional and Bayesian analyses, we found that individuals who worried about getting sick worked harder to protect themselves and others. However, concern about the coronavirus itself did not account for all of the variances in experienced stress during the early months of COVID-19 restrictions. More alarmingly, such stress was associated with less compliance. Further, those most concerned over the coronavirus trusted in government measures primarily where policies were strict. While concern over a disease is a source of mental distress, other factors including strictness of protective measures, social support and personal lockdown conditions must also be taken into consideration to fully appreciate the psychological impact of COVID-19 and to understand why some people fail to follow behavioural guidelines intended to protect themselves and others from infection. The Stage 1 manuscript associated with this submission received in-principle acceptance (IPA) on 18 May 2020. Following IPA, the accepted Stage 1 version of the manuscript was preregistered on the Open Science Framework at https://osf.io/g2t3b. This preregistration was performed prior to data analysis.