Suchergebnisse

Living cells can be modelled by successively imposing known constraints that limit their behaviour, such as mass balances, thermodynamic laws or enzyme capacities. The resulting constraint-based models enclose all the functional states that the modelled cells may exhibit. Then, predictions can be obtained from the models in two main ways: adding experimental data to determine the state of cells at given conditions (MFA) or invoking an assumption of evolved optimal behaviour (FBA). Both MFA and FBA predictions are typically performed at steady state. However, it is easy to take extracellular dynamics into account. This work explores the benefits of using possibility theory to get these dynamic predictions. It will be shown that the possibilistic methods (a) provide rich estimates for time-varying fluxes and metabolite concentrations, (b) account for uncertainty and data scarcity, and (c) give predictions relaxing the optimality assumption of FBA. On the other hand, these methods could serve as basis for monitoring and fault detection systems in industrial bioprocesses. ; This research has been partially supported by the Spanish Government MINECO (1st and 3rd authors are grateful to grant CICYT DPI2011-28112-C04-01, and A. Sala is grateful to grant DPI2011-27845-C02-01). ; Llaneras Estrada, F.; Sala, A.; Picó Marco, JA. (2012). Dynamic estimations of metabolic fluxes with constraint-based models and possibility theory. Journal of Process Control. 22(10):1946-1955. https://doi.org/10.1016/j.jprocont.2012.09.001 ; S ; 1946 ; 1955 ; 22 ; 10

Background: Metabolic Flux Analysis (MFA) is a methodology that has been successfully applied to estimate metabolic fluxes in living cells. However, traditional frameworks based on this approach have some limitations, particularly when measurements are scarce and imprecise. This is very common in industrial environments. The PFA Toolbox can be used to face those scenarios. Results: Here we present the PFA (Possibilistic Flux Analysis) Toolbox for MATLAB, which simplifies the use of Interval and Possibilistic Metabolic Flux Analysis. The main features of the PFA Toolbox are the following: (a) It provides reliable MFA estimations in scenarios where only a few fluxes can be measured or those available are imprecise. (b) It provides tools to easily plot the results as interval estimates or flux distributions. (c) It is composed of simple functions that MATLAB users can apply in flexible ways. (d) It includes a Graphical User Interface (GUI), which provides a visual representation of the measurements and their uncertainty. (e) It can use stoichiometric models in COBRA format. In addition, the PFA Toolbox includes a User s Guide with a thorough description of its functions and several examples. Conclusions: The PFA Toolbox for MATLAB is a freely available Toolbox that is able to perform Interval and Possibilistic MFA estimations. ; This research has been partially supported by the Spanish Government (FEDER-CICYT: DPI 2014-55276-C5-1-R). Yeimy Morales is grateful for the BR Grants of the University of Girona (BR2012/26). Gabriel Bosque Chacon is recipient of a doctoral fellowship from the Spanish Government (BES-2012-053772). ; Morales, Y.; Bosque Chacón, G.; Vehi, J.; Picó Marco, JA.; Llaneras, F. (2016). PFA toolbox: a MATLAB tool for Metabolic Flux Analysis. BMC Systems Biology. 10(46):1-10. https://doi.org/10.1186/s12918-016-0284-1 ; S ; 1 ; 10 ; 10 ; 46 ; Sauer U, Hatzimanikatis V, Bailey J, Hochuli M, Szyperski T, Wuethrich K. Metabolic fluxes in riboflavin-producing Bacillus subtilis. Nature biotechnology. ...

This paper deals with the estimation of unknown signals in bioreactors using sliding observers. Particular attention is drawn to estimate the specific growth rate of microorganisms from measurement of biomass concentration. In a recent article, notions of high-order sliding modes have been used to derive a growth rate observer for batch processes. In this paper we generalize and refine these preliminary results. We develop a new observer with a different error structure to cope with other types of processes. Furthermore, we show that these observers are equivalent, under coordinate transformations and time scaling, to the classical super-twisting differentiator algorithm, thus inheriting all its distinctive features. The new observers' family achieves convergence to timevarying unknown signals in finite time, and presents the best attainable estimation error order in the presence of noise. In addition, the observers are robust to modeling and parameter uncertainties since they are based on minimal assumptions on bioprocess dynamics. In addition, they have interesting applications in fault detection and monitoring. The observers performance in batch, fed-batch and continuous bioreactors is assessed by experimental data obtained from the fermentation of Saccharomyces Cerevisiae on glucose. ; This work was supported by the National University of La Plata (Project 2012-2015), the Agency for the Promotion of Science and Technology ANPCyT (PICT2007-00535) and the National Research Council CONICET (PIP112-200801-01052) of Argentina; the Technical University of Valencia (PAID-02-09), the CICYT (DPI2005-01180) and AECID (A/024186/09) of Spain; and by the project FEDER of the European Union. ; De Battista, H.; Picó Marco, JA.; Garelli, F.; Navarro Herrero, JL. (2012). Reaction rate reconstruction from biomass concentration measurement in bioreactors using modified second-order sliding mode algorithms. Bioprocess and Biosystems Engineering. 35(9):1-11. https://doi.org/10.1007/s00449-012-0752-y ; S ; 1 ; 11 ; 35 ; 9 ...

RESUMEN Se realizó una segunda reunión con la participación de líderes y pobladores de la comunidad, con el fin de dar a conocer nuestro objetivo de elaborar en conjunto un "PLAN DE DESARROLLO COMUNAL PARA EL ASENTAMIENTO HUMANO LAS TORRES DE SAN BORJA, 2020". Los temas desarrollados fueron Organización, Economía, Seguridad, Deporte, Servicios Básicos, Infraestructura, Urbanismo, Salud, Educación, Vivienda y Hábitat y Relaciones Humanas. Conviene precisar que la primera reunión con la comunidad se realizó en octubre del 2015 firmando un Acta de Compromiso por los tres agentes de cambio Universidad Privada del Norte, Centro de Atención y Educación a la Familia CAEF y la Comunidad AAHH Las Torres de San Borja, comprometiéndose a mantener un diálogo frecuente y apoyo en marco de nuestro proyecto UNIONES. Nuestro Equipo de trabajo, Docente Ms Lic Marlies Cueva Urra y Director de Carrera de Economía Econ. Jesús Benitez Gamboa de la Universidad Privada Del Norte participaron en el conversatorio con líderes y habitantes donde se habló de sus anhelos hacia el 2020, donde la comunidad dio a conocer sus carencias en temas de seguridad ciudadana, el transporte, servicio básico, también se hizo una serie de preguntas en el cual cada uno dio su punto de vista respecto a los problemas sociales que enfrenta la población: escasos recursos y la carencia de ayuda del Estado. También se realizó un compartir con todos los presentes fortaleciendo lazos y comprometiéndonos con el objetivo trazado. ; ABSTRACT A second meeting was held with the participation of both the inhabitants and leaders of the Torres de San Borja Community for the "Torres de San Borja Community Development Plan", in order to know our activities schedules and, with everyone's help, manage to complete said Community Development Plan for the year 2020 by the end of the semester. The Topics at hand were such as organization, economy, security, sports, basic utilities, infrastructure, urbanism, healthcare, education, welfare and habitat and human relations. Along with our teacher Marlies and the Principal of the Economy School of Universidad Privada del Norte, our team took part in this meeting, and while talking with the inhabitants and leaders of TSB, they spoke of their yearnings for the year 2020 regarding their community, and they also mentioned their needs in terms of security, transport and all the other topics previously mentioned. We also had a piece of their minds regarding the social problems in their community and the shortage in support from the state government. We also had a snack with all of the attendants and we had a raffle with some small gifts, this was done in the spirit of sharing and bonding with the good people of the Torres de San Borja Human Settlement, and to celebrate our commitment to our work.

[EN] Within the emergent field of Systems Biology, mathematical models obtained from physical chemical laws (the so-called first principles-based models) of microbial systems are employed to discern the principles that govern cellular behaviour and achieve a predictive understanding of cellular functions. The reliance on this biochemical knowledge has the drawback that some of the assumptions (specific kinetics of the reaction system, unknown dynamics and values of the model parameters) may not be valid for all the metabolic possible states of the network. In this uncertainty context, the combined use of fundamental knowledge and data measured in the fermentation that describe the behaviour of the microorganism in the manufacturing process is paramount to overcome this problem. In this paper, a grey modelling approach is presented combining data-driven and first principles information at different scales, developed for Pichia pastoris cultures grown on different carbon sources. This approach will allow us to relate patterns of recombinant protein production to intracellular metabolic states and correlate intra and extracellular reactions in order to understand how the internal state of the cells determines the observed behaviour in P. pastoris cultivations. ; Research in this study was partially supported by the Spanish Ministry of Science and Innovation and FEDER funds from the European Union through grants DPI2011-28112-C04-01 and DPI2011-28112-C04-02. The authors are also grateful to Biopolis SL for supporting this research. We also gratefully acknowledge Associate Professor Jose Camacho for providing the Exploratory Data Analysis Toolbox. ; González Martínez, JM.; Folch-Fortuny, A.; Llaneras Estrada, F.; Tortajada Serra, M.; Picó Marco, JA.; Ferrer, A. (2014). Metabolic flux understanding of Pichia pastoris grown on heterogenous culture media. Chemometrics and Intelligent Laboratory Systems. 134:89-99. https://doi.org/10.1016/j.chemolab.2014.02.003 ; S ; 89 ; 99 ; 134

[EN] With the aim of understanding the flux distributions across a metabolic network, i.e. within living cells, Principal Component Analysis (PCA) has been proposed to obtain a set of orthogonal components (pathways) capturing most of the variance in the flux data. The problems with this method are (i) that no additional information can be included in the model, and (ii) that orthogonality imposes a hard constraint, not always reasonably. To overcome these drawbacks, here we propose to use a more flexible approach such as Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) to obtain this set of biological pathways through the network. By using this method, different constraints can be included in the model, and the same source of variability can be present in different pathways, which is reasonable from a biological standpoint. This work follows a methodology developed for Pichia pastoris cultures grown on different carbon sources, lately presented in González-Martínez et al. (2014). In this paper a different grey modelling approach, which aims to incorporate a priori knowledge through constraints on the modelling algorithms, is applied to the same case of study. The results of both models are compared to show their strengths and weaknesses. ; Research in this study was partially supported by the Spanish Ministry of Science and Innovation and FEDER funds from the European Union through grants DPI2011-28112-C04-01 and DPI2011-28112-C04-02. The authors are also grateful to Biopolis SL for supporting this research. ; Folch-Fortuny, A.; Tortajada Serra, M.; Prats-Montalbán, JM.; Llaneras Estrada, F.; Picó Marco, JA.; Ferrer Riquelme, AJ. (2015). MCR-ALS on metabolic networks: Obtaining more meaningful pathways. Chemometrics and Intelligent Laboratory Systems. 142:293-303. https://doi.org/10.1016/j.chemolab.2014.10.004 ; S ; 293 ; 303 ; 142

This is an open access article under the CC BY license.-- Sponsoring Consortium for Open Access Publishing in Particle Physics - SCOAP3.-- et al. ; Measurements of the five most significant angular coefficients, A0 through A4 , for Z bosons produced in pp collisions at s=8 TeV and decaying to μ+μ− are presented as a function of the transverse momentum and rapidity of the Z boson. The integrated luminosity of the dataset collected with the CMS detector at the LHC corresponds to 19.7fb−1 . These measurements provide comprehensive information about the Z boson production mechanisms, and are compared to the QCD predictions at leading order, next-to-leading order, and next-to-next-to-leading order in perturbation theory. Elsevier ; Individuals have received support from the Marie-Curie program and the European Research Council and EPLANET (European Union); the Leventis Foundation; the A.P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium); the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Council of Scientific and Industrial Research, India; the HOMING PLUS program of the Foundation for Polish Science, cofinanced from European Union, Regional Development Fund; the Compagnia di San Paolo (Torino); the Consorzio per la Fisica (Trieste); MIUR project 20108T4XTM (Italy); the Thalis and Aristeia programs cofinanced by EU-ESF and the Greek NSRF; and the National Priorities Research Program by Qatar National Research Fund. ; Funded by SCOAP3. ; Peer reviewed

The CMS collaboration: et al. ; Bose-Einstein correlations of charged hadrons are measured over a broad multiplicity range, from a few particles up to about 250 reconstructed charged hadrons in proton-proton collisions at s√ = 13 TeV. The results are based on data collected using the CMS detector at the LHC during runs with a special low-pileup configuration. Three analysis techniques with different degrees of dependence on simulations are used to remove the non-Bose-Einstein background from the correlation functions. All three methods give consistent results. The measured lengths of homogeneity are studied as functions of particle multiplicity as well as average pair transverse momentum and mass. The results are compared with data from both CMS and ATLAS at s√ = 7 TeV, as well as with theoretical predictions. ; Individuals have received support from the Marie-Curie program and the European Research Council and Horizon 2020 Grant, contract Nos. 675440, 752730, and 765710 (European Union); the Leventis Foundation; the A.P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium); the F.R.S.-FNRS and FWO (Belgium) under the "Excellence of Science — EOS" — be.h project n. 30820817; the Beijing Municipal Science & Technology Commission, No. Z181100004218003; the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Lend¨ulet ("Momentum") Program and the J´anos Bolyai Research Scholarship of the Hungarian Academy of Sciences, the New National Excellence Program UNKP, the NKFIA research grants 123842, 123959, 124845, 124850, 125105, 128713, 128786, and 129058 (Hungary); the Council of Science and Industrial Research, India; the HOMING PLUS program of the Foundation for Polish Science, cofinanced from European Union, Regional Development Fund, the Mobility Plus program of the Ministry of Science and Higher Education, the National Science Center (Poland), contracts Harmonia 2014/14/M/ST2/00428, Opus 2014/13/B/ST2/02543, 2014/15/B/ST2/03998, and 2015/19/B/ST2/02861, Sonatabis 2012/07/E/ST2/01406; the National Priorities Research Program by Qatar National Research Fund; the Ministry of Science and Education, grant no. 3.2989.2017 (Russia); the Programa Estatal de Fomento de la Investigacion Cientifica y T´ecnica de Excelencia Maria de Maeztu, grant MDM-2015-0509 and the Programa Severo Ochoa del Principado de Asturias; the Thalis and Aristeia programs cofinanced by EU-ESF and the Greek NSRF; the Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University and the Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand); the Nvidia Corporation; the Welch Foundation, contract C-1845; and the Weston Havens Foundation (U.S.A.). ; Article funded by SCOAP3 ; Peer reviewed

The CMS Collaboration: et al. ; The production of W±bosons is studied in proton-lead (pPb) collisions at a nucleon-nucleon centre-of-mass energy of √sNN=8.16 TeV. Measurements are performed in the W±→μ±νμchannel using a data sample corresponding to an integrated luminosity of 173.4 ±6.1nb−1, collected by the CMS Collaboration at the LHC. The number of positively and negatively charged W bosons is determined separately in the muon pseudorapidity region in the laboratory frame |ημlab| 25 GeV/c. The W±boson differential cross sections, muon charge asymmetry, and the ratios of W±boson yields for the proton-going over the Pb-going beam directions are reported as a function of the muon pseudorapidity in the nucleon-nucleon centre-of-mass frame. The measurements are compared to the predictions from theoretical calculations based on parton distribution functions (PDFs) at next-to-leading-order. The results favour PDF calculations that include nuclear modifications and provide constraints on the nuclear PDF global fits. ; Individuals have received support from the Marie-Curie pro-gramme and the European Research Council and Horizon 2020 Grant, contract Nos. 675440 and 765710 (European Union); the Leventis Foundation; the Alfred P. Sloan Foundation; the Alexan-der von Humboldt Foundation; the Belgian Federal Science Pol-icy Office; the Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium); the F.R.S.-FNRS and FWO (Belgium) under the "Excellence of Sci-ence – EOS" – be.h project n. 30820817; the Beijing Municipal Science & Technology Commission, No. Z181100004218003; the Ministry of Education, Youth and Sports (MEYS) of the Czech Re-public; the Lendület ("Momentum") Programme and the János Bolyai Research Scholarship of the Hungarian Academy of Sci-ences, the New National Excellence Program ÚNKP, the NKFIA research grants 123842, 123959, 124845, 124850, 125105, 128713, 128786, and 129058 (Hungary); the Council of Science and In-dustrial Research, India; the HOMING PLUS programme of the Foundation for Polish Science, cofinanced from European Union, Regional Development Fund, the Mobility Plus programme of the Ministry of Science and Higher Education, the National Science Center (Poland), contracts Harmonia 2014/14/M/ST2/00428, Opus 2014/13/B/ST2/02543, 2014/15/B/ST2/03998, and 2015/19/B/ST2/02861, Sonata-bis 2012/07/E/ST2/01406; the National Priorities Re-search Program by Qatar National Research Fund; the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia María de Maeztu, grant MDM-2015-0509 and the Pro-grama Severo Ochoa del Principado de Asturias; the Thalis and Aristeia programmes cofinanced by EU-ESF and the Greek NSRF; the Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chula-longkorn University and the Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand); The Welch Foun-dation, contract C-1845; and the Weston Havens Foundation (USA) ; Funded by SCOAP3. ; Peer reviewed

The CMS Collaboration: et al. ; Measurements of the cross sections for the production of single top quarks and antiquarks in the tchannel, and their ratio, are presented for proton-proton collisions at a center-of-mass energy of 13 TeV. The data set used was recorded in 2016 by the CMS detector at the LHC and corresponds to an integrated luminosity of 35.9 fb−1. Events with one muon or electron are selected, and different categories of jet and bjet multiplicity and multivariate discriminators are applied to separate the signal from the background. The cross sections for the t-channel production of single top quarks and antiquarks are measured to be 130 ±1(stat) ±19(syst)pb and 77 ±1(stat) ±12(syst)pb, respectively, and their ratio is 1.68 ±0.02(stat) ±0.05(syst). The results are in agreement with the predictions from the standard model. ; Individuals have received support from the Marie-Curie pro-gram and the European Research Council and Horizon 2020 Grant, contract No. 675440 (European Union); the Leventis Founda-tion; the A.P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation à la Recherche dans l'Industrie et dans l'A-griculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium); the F.R.S.-FNRS and FWO (Belgium) under the "Excellence of Science – EOS" – be.h project n. 30820817; the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Lendület ("Momentum") Pro-gram and the János Bolyai Research Scholarship of the Hun-garian Academy of Sciences, the New National Excellence Pro-gram ÚNKP, the NKFIA research grants 123842, 123959, 124845, 124850, and 125105 (Hungary); the Council of Science and In-dustrial Research, India; the HOMING PLUS program of the Foun-dation for Polish Science, cofinanced from European Union, Re-gional Development Fund, the Mobility Plus program of the Ministry of Science and Higher Education, the National Science Center (Poland), contracts Harmonia 2014/14/M/ST2/00428, Opus 2014/13/B/ST2/02543, 2014/15/B/ST2/03998, and 2015/19/B/ST2/02861, Sonata-bis 2012/07/E/ST2/01406; the National Priorities Re-search Program by Qatar National Research Fund; the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia María de Maeztu, grant MDM-2015-0509 and the Pro-grama Severo Ochoa del Principado de Asturias; the Thalis and Aristeia programs cofinanced by EU-ESF and the Greek NSRF; the Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chula-longkorn University and the Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand); The Welch Foun-dation, contract C-1845; and the Weston Havens Foundation (USA). ; Funded by SCOAP3. ; Peer reviewed

CMS Collaboration: et al. ; The second- and third-order azimuthal anisotropy Fourier harmonics of charged particles produced in pPb collisions, at √sNN=8.16TeV, are studied over a wide range of event multiplicities. Multiparticle correlations are used to isolate global properties stemming from the collision overlap geometry. The second-order "elliptic" harmonic moment is obtained with high precision through four-, six-, and eight-particle correlations and, for the first time, the third-order "triangular" harmonic moment is studied using four-particle correlations. A sample of peripheral PbPb collisions at √sNN=5.02TeV that covers a similar range of event multiplicities as the pPb results is also analyzed. Model calculations of initial-state fluctuations in pPb and PbPb collisions can be directly compared to the high-precision experimental results. This work provides new insight into the fluctuation-driven origin of the v3 coefficients in pPb and PbPb collisions, and into the dominating overall collision geometry in PbPb collisions at the earliest stages of heavy ion interactions. ; Individuals have received support from the Marie-Curie program and the European Research Council and Horizon 2020 Grant, Contracts No. 675440 and No. 765710 (European Union); the Leventis Foundation; the A.P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium); the F.R.S.-FNRS and FWO (Belgium) under the "Excellence of Science–EOS" be.h Project No. 30820817; the Beijing Municipal Science & Technology Commission, No. Z181100004218003; the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Lendület ("Momentum") Program and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences, the New National Excellence Program ÚNKP, the NKFIA Research Grants No. 123842, No. 123959, No. 124845, No. 124850, No. 125105, No. 128713, No. 128786, and No. 129058 (Hungary); the Council of Science and Industrial Research, India; the HOMING PLUS program of the Foundation for Polish Science, cofinanced from European Union, Regional Development Fund, the Mobility Plus program of the Ministry of Science and Higher Education, the National Science Center (Poland), contracts Harmonia 2014/14/M/ST2/00428, Opus 2014/13/B/ST2/02543, 2014/15/B/ST2/03998, and 2015/19/B/ST2/02861, and Sonata-bis 2012/07/E/ST2/01406; the National Priorities Research Program by Qatar National Research Fund; the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia María de Maeztu, Grant No. MDM2015-0509 and the Programa Severo Ochoa del Principado de Asturias; the Thalis and Aristeia programs cofinanced by EU-ESF and the Greek NSRF; the Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University and the Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand); the Welch Foundation, Contract No. C-1845; and the Weston Havens Foundation (USA). ; Funded by SCOAP3. ; Peer reviewed

CMS Collaboration: et al. ; Normalised multi-differential cross sections for top quark pair (tt¯) production are measured in proton-proton collisions at a centre-of-mass energy of 13TeV using events containing two oppositely charged leptons. The analysed data were recorded with the CMS detector in 2016 and correspond to an integrated luminosity of 35.9fb−1. The double-differential tt¯ cross section is measured as a function of the kinematic properties of the top quark and of the tt¯ system at parton level in the full phase space. A triple-differential measurement is performed as a function of the invariant mass and rapidity of the tt¯ system and the multiplicity of additional jets at particle level. The data are compared to predictions of Monte Carlo event generators that complement next-to-leading-order (NLO) quantum chromodynamics (QCD) calculations with parton showers. Together with a fixed-order NLO QCD calculation, the triple-differential measurement is used to extract values of the strong coupling strength αS and the top quark pole mass (mpolet) using several sets of parton distribution functions (PDFs). The measurement of mpolet exploits the sensitivity of the tt¯ invariant mass distribution to mpolet near the production threshold. Furthermore, a simultaneous fit of the PDFs, αS, and mpolet is performed at NLO, demonstrating that the new data have significant impact on the gluon PDF, and at the same time allow an accurate determination of αS and mpolet. The values αS(mZ)=0.1135+0.0021−0.0017 and mpolet=170.5±0.8GeV are extracted, which account for experimental and theoretical uncertainties, the latter being estimated from NLO scale variations. Possible effects from Coulomb and soft-gluon resummation near the tt¯ production threshold are neglected in these parameter extractions. A rough estimate of these effects indicates an expected correction of mpolet of the order of +1GeV, which can be regarded as additional theoretical uncertainty in the current mpolet extraction. ; Individuals have received support from the Marie-Curie programme and the European Research Council and Horizon 2020 Grant, contract Nos. 675440 and 765710 (European Union); the Leventis Foundation; the A.P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWTBelgium); the F.R.S.-FNRS and FWO (Belgium) under the "Excellence of Science – EOS" – be.h project No. 30820817; the Beijing Municipal Science & Technology Commission, No. Z181100004218003; the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Lendület ("Momentum") Programme and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences, the New National Excellence Program ÚNKP, the NKFIA research grants 123842, 123959, 124845, 124850, 125105, 128713, 128786, and 129058 (Hungary); the Council of Scientific and Industrial Research, India; the HOMING PLUS programme of the Foundation for Polish Science, cofinanced from European Union, Regional Development Fund, the Mobility Plus programme of the Ministry of Science and Higher Education, the National Science Center (Poland), contracts Harmonia 2014/14/M/ST2/00428, Opus 2014/13/B/ST2/02543, 2014/15/B/ST2/03998, and 2015/19/B/ST2/02861, Sonata-bis 2012/07/E/ST2/01406; the National Priorities Research Program by Qatar National Research Fund; the Programa de Excelencia María de Maeztu, and the Programa Severo Ochoa del Principado de Asturias; the Thalis and Aristeia programmes cofinanced by EU-ESF, and the Greek NSRF; the Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University, and the Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand); the Welch Foundation, contract C-1845; and the Weston Havens Foundation (USA) ; Funded by SCOAP3. ; Peer reviewed

et al. ; Measurements of the top quark-antiquark (tt¯) spin correlations and the top quark polarization are presented for tt¯ pairs produced in pp collisions at √s=8 TeV. The data correspond to an integrated luminosity of 19.5 fb−1 collected with the CMS detector at the LHC. The measurements are performed using events with two oppositely charged leptons (electrons or muons) and two or more jets, where at least one of the jets is identified as originating from a bottom quark. The spin correlations and polarization are measured from the angular distributions of the two selected leptons, both inclusively and differentially, with respect to the invariant mass, rapidity, and transverse momentum of the tt¯ system. The measurements are unfolded to the parton level and found to be in agreement with predictions of the standard model. A search for new physics in the form of anomalous top quark chromo moments is performed. No evidence of new physics is observed, and exclusion limits on the real part of the chromo-magnetic dipole moment and the imaginary part of the chromo-electric dipole moment are evaluated. ; Individuals have received support from the Marie-Curie programme and the European Research Council and EPLANET (European Union); the Leventis Foundation; the A. P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWTBelgium); the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Council of Science and Industrial Research, India; the HOMING PLUS programme of the Foundation for Polish Science, cofinanced from European Union, Regional Development Fund; the OPUS programme of the National Science Center (Poland); the Compagnia di San Paolo (Torino); MIUR project 20108T4XTM (Italy); the Thalis and Aristeia programmes cofinanced by EU-ESF and the Greek NSRF; the National Priorities Research Program by Qatar National Research Fund; the Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University (Thailand); the Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand); and the Welch Foundation, Contract No. C-1845. ; Peer Reviewed

et al. ; A search for evidence of particle dark matter (DM) and unparticle production at the LHC has been performed using events containing two charged leptons, consistent with the decay of a Z boson, and large missing transverse momentum. This study is based on data collected with the CMS detector corresponding to an integrated luminosity of 19.7 fb−1 of pp collisions at the LHC at a center-of-mass energy of 8 TeV. No significant excess of events is observed above the number expected from the standard model contributions. The results are interpreted in terms of 90% confidence level limits on the DM-nucleon scattering cross section, as a function of the DM particle mass, for both spin-dependent and spin-independent scenarios. Limits are set on the effective cutoff scale Λ, and on the annihilation rate for DM particles, assuming that their branching fraction to quarks is 100%. Additionally, the most stringent 95% confidence level limits to date on the unparticle model parameters are obtained. ; Individuals have received support from the Marie-Curie program and the European Research Council and EPLANET (European Union); the Leventis Foundation; the A. P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium); the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Council of Science and Industrial Research, India; the HOMING PLUS program of the Foundation for Polish Science, cofinanced by the European Union, Regional Development Fund; the OPUS program of the National Science Center (Poland); the Compagnia di San Paolo (Torino); MIUR Project No. 20108T4XTM (Italy); the Thalis and Aristeia programs cofinanced by EU-ESF and the Greek NSRF; the National Priorities Research Program by Qatar National Research Fund; the Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University (Thailand); and the Welch Foundation, Contract No. C-1845. ; Peer Reviewed

et al. ; A search for the production of a heavy B quark, having electric charge −1/3 and vector couplings to W, Z, and H bosons, is carried out using proton-proton collision data recorded at the CERN LHC by the CMS experiment, corresponding to an integrated luminosity of 19.7 fb−1. The B quark is assumed to be pair produced and to decay in one of three ways: to tW, bZ, or bH. The search is carried out in final states with one, two, and more than two charged leptons, as well as in fully hadronic final states. Each of the channels in the exclusive final-state topologies is designed to be sensitive to specific combinations of the B quark-antiquark pair decays. The observed event yields are found to be consistent with the standard model expectations in all the final states studied. A statistical combination of these results is performed, and upper limits are set on the cross section of the strongly produced B quark-antiquark pairs as a function of the B quark mass. Lower limits on the B quark mass between 740 and 900 GeV are set at a 95% confidence level, depending on the values of the branching fractions of the B quark to tW, bZ, and bH. Overall, these limits are the most stringent to date. ; Individuals have received support from the Marie-Curie program and the European Research Council and EPLANET (European Union); the Leventis Foundation; the A. P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture (Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (Belgium); the Ministry of Education, Youth and Sports of the Czech Republic; the Council of Science and Industrial Research, India; the HOMING PLUS program of the Foundation for Polish Science, cofinanced from European Union, Regional Development Fund; the Compagnia di San Paolo (Torino); the Consorzio per la Fisica (Trieste); MIUR Project No. 20108T4XTM (Italy); the Thalis and Aristeia programs cofinanced by EU-ESF and the Greek NSRF; the National Priorities Research Program by Qatar National Research Fund; the Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University (Thailand); and the Welch Foundation. ; Peer Reviewed