Suchergebnisse

El presente texto consiste en un somero análisis biográfico, socio-político y económico que nos acerca a los orígenes y a los instrumentos de control social con que contó uno de los apellidos más destacados de la Restauración española, el de Gamazo. Para ello, nos centraremos de un modo especial en el último tercio del siglo XIX y en el personaje articulador de esta familia, a su vez uno de los prohombres más significativos de este período histórico: el vallisoletano diputado a Cortes y ministro liberal en varias legislaturas, Germán Gamazo. ; This text consists of a shallow economic, socio-political, and biographic analysis that brings us closer to the origins and social control instruments that were used by one of the most outstanding names of the Spanish Restoration, the name of Gamazo. For this purpose, we are going to pay a special attention to the last third of the nineteenth century and to the main character in the Gamazo family, one of the most significant leaders of this historical period: the parliamentary deputy for Valladolid and liberal minister in several legislatures, Germán Gamazo.

The repair of DNA breaks takes place in the context of chromatin and thus involves the activity of chromatin remodelers. The nucleosome acetyltransferase of H4 (NuA4) remodeler complex enables DNA break repair by relaxing flanking chromatin. Here, we show that MRG domain binding protein (MRGBP), a member of this complex, acts as a general inhibitor of DNA double-strand break repair. Upon its downregulation, repair is generally increased. This is particularly evident for the stimulation of early events of homologous recombination. Thus, MRGBP has an opposing role to the main catalytic subunits of the NuA4 complex. Our data suggest that MRGBP acts by limiting the activity of this complex in DNA repair, specifically by narrowing the extent of DNA-end resection. ; This work was funded by a R+D+I grant from the Spanish Ministry of Economy and Competitivity (SAF2016-74855-P) and by the European Union Regional Funds (FEDER). GR-L was supported by the Regional Government of Andalucía (Junta de Andalucía) with a contract of the program 'GARANTÍA JUVENIL EN LA UNIVERSIDAD DE SEVILLA'. CABIMER is supported by the regional government of Andalucía (Junta de Andalucía).