Suchergebnisse

Optical coherence tomography (OCT) angiography is a well-established in vivo imaging technique to assess the overall vascular morphology of tissues and is an emerging field of research for the assessment of blood flow dynamics and functional parameters such as oxygen saturation. In this study, we present a modified scanning-based correlation mapping OCT using a 200 kHz high-speed swept-source OCT system operating at 1300 nm and demonstrate its wide field-imaging capability in ocular angiographic studies. (C) 2018 Optical Society of America ; National Biophotonics Imaging Platform Ireland (Higher Education Authority PRTLI Cycle 4); Irish Government; European Union Investing in your future. ; peer-reviewed

A technique based on multiple reference optical coherence tomography (MR-OCT) is proposed for simultaneous imaging at multiple depths. The technique has been validated by imaging a reference sample and a fingerprint in-vivo. The principle of scanning multiple selected layers is shown by imaging a partial fingerprint with 200 x 200 x 200 voxels of 3 x 3 x 0.5 mm size and obtaining an arbitrary amount of layers merely by digital processing. The spacing among the layers can be adjusted arbitrarily, and the SNR roll-off is shown for three different spacings. At a mirror scan frequency of 1 kHz and an A-line rate of 2 kHz, the acquisition time was 20 s for one volume. The results show the feasibility of the application of layer scanning MR-OCT that uses a partial mirror in the reference arm of the Michelson interferometer. The reduced scan range required for layer scanning allows even higher scan rates that are limited only by the voice coil design and the mass-spring system, e.g., mirror mass, spring constant, and damping. (c) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE) ; This work was supported by the National University of Ireland (NUI) Galway, the Galway University Foundation, the University of Limerick Foundation, the National Biophotonics Imaging Platform, Ireland, funded under the Higher Education Authority PRTLI Cycle 4, cofunded by the Irish Government and the European Union—Investing in your future, and Compact Imaging, Inc. All authors have a financial interest in Compact Imaging, Inc. The acquisition of the in-vivo samples do not affect any ethical, health, or privacy concerns and were performed according to the ethical regulations and safety standards of the NUI Galway. ; peer-reviewed