Suchergebnisse

Nitrated polycyclic aromatic hydrocarbons (nitro‐PAHs) constitute a group of substances formed during incomplete combustion. Sources include diesel vehicles, heating, smoking, certain types of food‐processing, and incomplete combustion in general. 2‐Nitrofluorene (NF) represents a model substance for the nitro‐PAHs. An attempt has been made to estimate the lifetime human cancer risk due to background exposure to nitro‐PAHs by two different models. The first model is based on genotoxic lesions produced by gamma‐irradiation and the second model is based on an earlier published mega study (24,000 animals) on the carcinogenicity of the major metabolite of NF. Both models agreed well‐representing a yearly human cancer risk in the range of 0.15–49 × 10−6 for an urban citizen. The weaknesses and strengths of the models are discussed.