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[EN] Cardiovascular remodeling induced by intrauterine growth restriction manifests in adulthood by more globular ventricles, as evidenced by in vivo measurements. The angle between the dominant vectors of the QRS and T-wave loops has been reported to be significantly altered as a result of the induced remodeling. To investigate whether the more globular ventricular shape was a major factor contributing to such alteration, we performed electrophysiological simulations in a human biventricular model for control and in a model obtained by deforming the control one to represent a more spherical left ventricle (SLV). Transmural ventricular heterogeneities and a Purkinje network were included. 12-lead ECGs were calculated, from which spatial QRS and T-wave angles were computed. The angle between the T-wave and the XZ-plane was found to increase in the SLV model, showing a variation similar to that reported in in vivo studies. However, the angle between the dominant vectors of the QRS and T-wave loops projected onto the XY-plane was lower for control, contrary to clinical observations in IUGR adults. Other clinical results could not be reproduced in our simulations either. Our findings suggest that a more globular left ventricular shape leads to changes in the angles of QRS and T-wave loops, but further research is needed to fully understand these changes and the underlying mechanisms ; I would like to acknowledge support by Fundaci ' on Carolina, Universidad de Zaragoza and Universidad Polit ' ecnica Salesiana through its doctoral scholar-ship. This work was supported by projects ERC-StG 638284 (ERC), PID2019-105674RB-I00 and PID2019104881RB-I00 (MICINN) and LMP124-18 and reference group T39-20R (Arag ' on Government cofunded by FEDER 2014-2020 "Building Europe from Aragon"). Computations were performed using ICTS NANBIOSIS (HPC unit at U. Zaragoza). N. Ortigosa acknowledges support from Generalitat Valenciana under grant Prometeo/2017/102 and Spanish MINECO under grant MTM2016-76647-P ; Bueno-Palomeque, FL.; ...

[EN] Intrauterine Growth Restriction (IUGR) and premature birth are associated with higher risk of cardiovascular diseases throughout adulthood. The aim of this study was to evaluate the influence of these factors in ventricular electrical remodeling in preadolescents. Electrocardiography was performed in a cohort of 33-IUGR, 32-preterm with appropriate weight and 60 controls. Depolarization and repolarization processes were studied by means of the surface ECG, including loops and angles corresponding to QRS and T-waves. The angles between the dominant vector of QRS and the frontal plane XY were different among the study groups: controls [20.03 degrees(10.11 degrees-28.64 degrees)], preterm [25.48 degrees(19.79 degrees-33.56 degrees)], and IUGR [27.77 degrees(16.59 degrees-33.23 degrees)]. When compared to controls, IUGR subjects also presented wider angles between the difference of QRS and T-wave dominant vectors and the XY-plane [5.28 degrees +/- 12.15 degrees vs 0.49 degrees +/- 14.15 degrees, p 0.05] while preterm ones showed smaller frontal QRS-T angle [4.68 degrees(2.20 degrees-12.89 degrees) vs 6.57 degrees(2.72 degrees-11.31 degrees), p 0.05]. Thus, electrical remodeling is present in IUGR and preterm preadolescents, and might predispose them to cardiovascular diseases in adulthood. Follow-up studies are warranted. (C) 2016 Elsevier Inc. All rights reserved. ; N.Ortigosa acknowledgesthe support fromGeneralitatValenciana under grants PrometeoII/2013/013, ACOMP/2015/186, and MINECO under grant MTM2013-43540-P. This project has also been partially funded by TEC2013-42140-R and TIN2014-53567-R from CICYT, by Grupo Consolidado BSICoS from DGA (Aragon) and European Social Fund, the Erasmus + Program of the European Union (Framework Agreement number: 2013-0040), the South -Eastern Norway Regional Health Authority, the Bergesen foundation and grants from Instituto de Salud Carlos III (grant numbers PI12/00801 and PI14/00226); Ministerio de Economia y Competitividad (grant number SAF2012-37196), cofinanced by the ...

Intrauterine Growth Restriction (IUGR) and premature birth are associated with higher risk of cardiovascular diseases throughout adulthood. The aim of this study was to evaluate the influence of these factors in ventricular electrical remodeling in preadolescents. Electrocardiography was performed in a cohort of 33-IUGR, 32-preterm with appropriate weight and 60 controls. Depolarization and repolarization processes were studied by means of the surface ECG, including loops and angles corresponding to QRS and T-waves. The angles between the dominant vector of QRS and the frontal plane XY were different among the study groups: controls [20.03°(10.11°-28.64°)], preterm [25.48°(19.79°-33.56°)], and IUGR [27.77°(16.59°-33.23°)]. When compared to controls, IUGR subjects also presented wider angles between the difference of QRS and T-wave dominant vectors and the XY-plane [5.28° ± 12.15° vs 0.49° ± 14.15°, p < 0.05] while preterm ones showed smaller frontal QRS-T angle [4.68°(2.20°-12.89°) vs 6.57°(2.72°-11.31°), p < 0.05]. Thus, electrical remodeling is present in IUGR and preterm preadolescents, and might predispose them to cardiovascular diseases in adulthood. Follow-up studies are warranted. ; N. Ortigosa acknowledges the support from Generalitat Valenciana under grants PrometeoII/2013/013, ACOMP/2015/186, and MINECO under grant MTM2013-43540-P. This project has also been partially funded by TEC2013-42140-R and TIN2014-53567-R from CICYT, by Grupo Consolidado BSICoS from DGA (Aragón) and European Social Fund, the Erasmus + Program of the European Union (Framework Agreement number: 2013-0040), the South-Eastern Norway Regional Health Authority, the Bergesen foundation and grants from Instituto de Salud Carlos III (grant numbers PI12/00801 and PI14/00226), Ministerio de Economía y Competitividad (grant number SAF2012-37196), cofinanced by the Fondo Europeo de Desarrollo Regional de la Unión Europea "Una manera de hacer Europa", Fundación Mutua Madrileña, Obra Social La Caixa (Spain), Cerebra Foundation for the Brain Injured Child (Carmarthen, Wales, UK), and the European Commission (VP2HF no.611823). This publication reflects the views only of the authors, and the Commission cannot be held responsible for any use which may be made of the information contained therein. The computation was performed by the ICTS 0707NANBIOSIS, by the High Performance Computing Unit of the CIBER in Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN) at the University of Zaragoza.

This paper shows an adaptive statistical test for QRS detection of electrocardiography (ECG) signals. The method is based on a M-ary generalized likelihood ratio test (LRT) defined over a multiple observation window in the Fourier domain. The motivations for proposing another detection algorithm based on maximum a posteriori (MAP) estimation are found in the high complexity of the signal model proposed in previous approaches which i) makes them computationally unfeasible or not intended for real time applications such as intensive care monitoring and (ii) in which the parameter selection conditions the overall performance. In this sense, we propose an alternative model based on the independent Gaussian properties of the Discrete Fourier Transform (DFT) coefficients, which allows to define a simplified MAP probability function. In addition, the proposed approach defines an adaptive MAP statistical test in which a global hypothesis is defined on particular hypotheses of the multiple observation window. In this sense, the observation interval is modeled as a discontinuous transmission discrete-time stochastic process avoiding the inclusion of parameters that constraint the morphology of the QRS complexes. ; This work has received research funding from the Spanish government (www.micinn.es) under project TEC2012 34306 (DiagnoSIS, Diagnosis by means of Statistical Intelligent Systems, 70K€) and projects P09-TIC-4530 (300K€) and P11-TIC-7103 (156K€) from the Andalusian government (http://www.juntadeandalucia.es/organismos/economiainnovacioncienciayempleo.html).